Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration DOI Creative Commons
Soriul Kim, Seogchan Kang,

Song E. Kim

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 14, 2025

Individual differences in sleep duration have been reported, and genetic components of identified showing various heritability. To identify variants that contribute to duration, we conducted a human genome-wide identification on performed confirmatory experiments using Drosophila model. Genome-wide association study was analyzed determine the with self-aware from two community-based cohort, Ansan (cohort 1, n = 4635) Ansung 2, 4205), recruited Korean Genome Epidemiology Study. single nucleotide (rs16948804 rs4887991) WW domain containing oxidoreductase (WWOX) gene were associated (p-values, 1.11 × 10− 7 2.05 7, retrospectively). examine functional relevance WWOX study, loss-of-function mutants. The deletion Wwox flies reduced quality average bout length during daytime increased night-time (all p-values < 0.01). Our findings suggested expression is both humans factors play role inter-individual variability characteristics.

Язык: Английский

Genetics of circadian rhythms and sleep in human health and disease DOI
Jacqueline M. Lane, Jingyi Qian, Emmanuel Mignot

и другие.

Nature Reviews Genetics, Год журнала: 2022, Номер 24(1), С. 4 - 20

Опубликована: Авг. 26, 2022

Язык: Английский

Процитировано

137
The translational neuroscience of sleep: A contextual framework DOI
Michael A. Grandner, Fabian‐Xosé Fernandez

Science, Год журнала: 2021, Номер 374(6567), С. 568 - 573

Опубликована: Окт. 28, 2021

Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists a social-environmental context. Contextualizing health with respect to its determinants—from individual- societal-level factors—would enable neuroscientists more effectively translate into clinical practice. Key challenges opportunities pertain (i) recognizing exploring sleep’s functional roles, (ii) clarifying causal mechanisms relation key outcomes, (iii) developing richer model systems, (iv) linking models known contextual factors, (v) leveraging advances multisensory technology. Meeting these would help transcend disciplinary boundaries such that considerations related become an ever-greater presence clinic.

Язык: Английский

Процитировано

117
Human circadian variations DOI Open Access
Nicholas W. Gentry, Liza Ashbrook, Ying‐Hui Fu

и другие.

Journal of Clinical Investigation, Год журнала: 2021, Номер 131(16)

Опубликована: Авг. 15, 2021

Circadian rhythms, present in most phyla across life, are biological oscillations occurring on a daily cycle. Since the discovery of their molecular foundations model organisms, many inputs that modify this tightly controlled system humans have been identified. Polygenic variations and environmental factors influence each person's circadian rhythm, contributing to trait known as chronotype, which manifests degree morning or evening preference an individual. Despite normal variation much society operates "one size fits all" schedule can be difficult adjust to, especially for certain individuals whose endogenous phase is extremely advanced delayed. This public health concern, misalignment associated with number adverse outcomes. Additionally, modern technology (such electric lights computer, tablet, phone screens emit blue light) lifestyles shift irregular work schedules) disrupting consistency increasing people. Though medical lifestyle interventions alleviate some these issues, growing research variability sensitivity suggests broader social changes may necessary minimize impact health.

Язык: Английский

Процитировано

88
Connecting insufficient sleep and insomnia with metabolic dysfunction DOI
Daisy Duan, Lenise Jihe Kim, Jonathan C. Jun

и другие.

Annals of the New York Academy of Sciences, Год журнала: 2022, Номер 1519(1), С. 94 - 117

Опубликована: Ноя. 13, 2022

Abstract The global epidemic of obesity and type 2 diabetes parallels the rampant state sleep deprivation in our society. Epidemiological studies consistently show an association between insufficient metabolic dysfunction. Mechanistically, circadian rhythm exert considerable influences on hormones involved appetite regulation energy metabolism. As such, data from experimental humans demonstrate that induces a positive balance with resultant weight gain, due to increased intake far exceeds additional expenditure nocturnal wakefulness, adversely impacts glucose Conversely, animal models have found loss–induced caloric resulting net loss. However, significant limitations, which may diminish clinical relevance their findings. Clinically, insomnia disorder symptoms are associated adverse outcomes, though it remains challenging isolate effects outcomes independent comorbidities durations. Furthermore, both pharmacological behavioral interventions for direct effects. goal this review is establish updated framework causal links risks obesity.

Язык: Английский

Процитировано

41
The night’s watch: Exploring how sleep protects against neurodegeneration DOI Creative Commons
Samira Parhizkar, David M. Holtzman

Neuron, Год журнала: 2025, Номер 113(6), С. 817 - 837

Опубликована: Март 1, 2025

Sleep loss is often regarded as an early manifestation of neurodegenerative diseases given its common occurrence and link to cognitive dysfunction. However, the precise mechanisms by which sleep disturbances contribute neurodegeneration are not fully understood, nor it clear why some individuals more susceptible these effects than others. This review addresses critical unanswered questions in field, including whether precede or result from diseases, functional significance changes during preclinical disease phase, potential role homeostasis adaptive mechanism enhancing resilience against decline neurodegeneration.

Язык: Английский

Процитировано

2
The SIK3-N783Y mutation is associated with the human natural short sleep trait DOI Creative Commons
Hongmin Chen,

Xing Ye,

Chunyan Wan

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(19)

Опубликована: Май 5, 2025

Sleep is an essential component of our daily life. A mutation in human salt induced kinase 3 (hSIK3), which critical for regulating sleep duration and depth rodents, associated with natural short (NSS), a condition characterized by reduced subjects. This NSS hSIK3-N783Y results diminished activity vitro. In mouse model, the presence leads to decrease time increase electroencephalogram delta power. At phosphoproteomic level, SIK3-N783Y induces substantial changes predominantly at synaptic sites. Bioinformatic analysis has identified several sleep-related alterations triggered mutation, including protein mitogen-activated kinase. These findings underscore conserved function SIK3 as gene regulation provide insights into regulatory network governing sleep.

Язык: Английский

Процитировано

1
Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations DOI Creative Commons
James B. Jaggard, Evan Lloyd,

Anders Yuiska

и другие.

Science Advances, Год журнала: 2020, Номер 6(38)

Опубликована: Сен. 16, 2020

Environmental perturbation can drive behavioral evolution and associated changes in brain structure function. The Mexican fish species,

Язык: Английский

Процитировано

61
Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal study DOI Creative Commons
Gillian Weston, Afshin Zilanawala, Elizabeth Webb

и другие.

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 27, 2024

Atypical temporal work patterns such as working longer than the standard 35-40 h/ week, weekend working, and nonstandard schedules (i.e. outside of typical 9-5, including but not restricted to shiftwork) are increasingly prevalent in UK. Aside from occupation-specific studies, little is known about effects these atypical on sleep among workers UK, even though poor has been linked adverse health problems, lower workplace productivity, economic costs.

Язык: Английский

Процитировано

8
Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait DOI Creative Commons
Guangsen Shi, Yin Chen, Zenghua Fan

и другие.

Current Biology, Год журнала: 2020, Номер 31(1), С. 13 - 24.e4

Опубликована: Окт. 15, 2020

Язык: Английский

Процитировано

43
The prevalence of sleep loss and sleep disorders in young and old adults DOI Creative Commons

Vibha M. Jha

Aging Brain, Год журнала: 2022, Номер 3, С. 100057 - 100057

Опубликована: Дек. 19, 2022

The ability to sleep declines with age. National Sleep Foundation, USA has recommended a minimum amount for all ages. Individuals who experience lesser than the could be sleep-deprived. Several factors like stress, altered circadian cycle, medical conditions, etc. cause deficiency. Almost 50-60 % of elderly population suffer from disorders such as apnea, restless legs syndrome, REM behavior disorder, Chronic deprivation may further lead development diseases Alzheimer's and Parkinson's. This paper reviews prevalence consequences loss in young old adults.

Язык: Английский

Процитировано

25