Aging and Disease,
Год журнала:
2025,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
Circadian
rhythm
is
the
internal
homeostatic
physiological
clock
that
regulates
24-hour
sleep/wake
cycle.
This
biological
helps
to
adapt
environmental
changes
such
as
light,
dark,
temperature,
and
behaviors.
Aging,
on
other
hand,
a
process
of
results
in
progressive
decline
cells,
tissues,
vital
systems
body.
Both
aging
circadian
are
highly
interlinked
phenomena
with
bidirectional
relationship.
The
leads
disruptions
while
dysfunctional
rhythms
promote
age-related
complications.
processes
involve
diverse
physiological,
molecular,
cellular
modifications
DNA
repair
mechanisms,
ROS
generation,
apoptosis,
cell
proliferation.
review
aims
examine
role
context
lung
cancer.
will
also
existing
literature
vice
versa.
Various
molecular
pathways
genes
BMAL1,
SIRT1,
HLF,
PER1
their
implications
aging,
rhythms,
cancer
be
discussed.
Royal Society of Chemistry eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 23, 2024
Circadian
rhythms
have
been
shown
to
be
ubiquitous
and
critically
important
in
the
experimental
laboratory,
accounting
for
difference
between
life
death
response
identical
stimulus.
The
partly
endogenous
nature
of
circadian
has
well
documented
methods
their
characterisation
developed
enabling
cellular
molecular
mechanisms
understood.
Chronobiology
Chronomedicine
aims
provide
a
review
these
underlying
illustrate
role
brain’s
suprachiasmatic
nuclei
‘pace-making’
process
effects
caused
by
‘clock
genes’
present
almost
all
cells.
Beyond
involved,
book
discusses
relationship
body
systems,
disease,
proper
function;
particular,
how
disruption
rhythm
is
associated
with
ill
health
disease
status
from
observations
made
at
organismic
level.
organised
an
ideal
introduction
postgraduate
various
fields,
reviewing
developments
outlining
show
depth
breadth
chronobiology
chronomedicine,
as
invaluable
companion
researchers
healthcare
professionals
working
field
interest
developing
novel
therapeutic
approaches.
Hypertension,
Год журнала:
2022,
Номер
80(3), С. 503 - 522
Опубликована: Ноя. 30, 2022
Healthy
individuals
exhibit
blood
pressure
variation
over
a
24-hour
period
with
higher
during
wakefulness
and
lower
sleep.
Loss
or
disruption
of
the
circadian
rhythm
has
been
linked
to
adverse
health
outcomes,
for
example,
cardiovascular
disease,
dementia,
chronic
kidney
disease.
However,
current
diagnostic
therapeutic
approaches
lack
sufficient
attention
rhythmicity
pressure.
Sleep
patterns,
hormone
release,
eating
habits,
digestion,
body
temperature,
renal
function,
other
important
host
functions
as
well
gut
microbiota
rhythms,
influence
rhythms
Potential
benefits
nonpharmacologic
interventions
such
meal
timing,
pharmacologic
chronotherapeutic
interventions,
bedtime
administration
antihypertensive
medications,
have
recently
suggested
in
some
studies.
mechanisms
underlying
rhythm-mediated
regulation
efficacy
chronotherapy
hypertension
remain
unclear.
This
review
summarizes
results
National
Heart,
Lung,
Blood
Institute
workshop
convened
on
October
27
29,
2021
assess
knowledge
gaps
research
opportunities
study
hypertension.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 11, 2023
The
biological
clock
system
is
an
intrinsic
timekeeping
device
that
integrates
internal
physiology
and
external
cues.
Maintaining
a
healthy
crucial
for
life.
Disruptions
to
the
body’s
can
lead
disturbances
in
sleep-wake
cycle
abnormalities
hormone
regulation,
blood
pressure,
heart
rate,
other
vital
processes.
Long-term
have
been
linked
development
of
various
common
major
diseases,
including
cardiovascular
metabolic
disorders,
tumors,
neuropsychiatric
conditions,
so
on.
External
factors,
such
as
diurnal
rhythm
light,
significant
impact
on
clock.
Additionally,
important
non-photic
zeitgeber,
exercise
regulate
rhythms
certain
extent,
making
it
possible
become
non-drug
intervention
preventing
treating
circadian
disorders.
This
comprehensive
review
encompasses
behavioral,
physiological,
molecular
perspectives
provide
deeper
understanding
how
influences
its
association
with
related
diseases.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7579 - 7579
Опубликована: Апрель 20, 2023
Mental
illness
is
alarmingly
on
the
rise,
and
circadian
disruptions
linked
to
a
modern
lifestyle
may
largely
explain
this
trend.
Impaired
rhythms
are
associated
with
mental
disorders.
The
evening
chronotype,
which
misalignment,
risk
factor
for
severe
psychiatric
symptoms
metabolic
comorbidities.
Resynchronization
of
commonly
improves
symptoms.
Furthermore,
evidence
indicates
that
preventing
misalignment
help
reduce
disorders
impact
neuro–immuno–metabolic
disturbances
in
psychiatry.
gut
microbiota
exhibits
diurnal
rhythmicity,
as
governed
by
meal
timing,
regulates
host’s
rhythms.
Temporal
regulation
feeding
has
emerged
promising
chronotherapeutic
strategy
prevent
and/or
treatment
illnesses,
through
modulation
microbiota.
Here,
we
provide
an
overview
link
between
disruption
illness.
We
summarize
connection
rhythms,
supporting
idea
aid
resynchronization
disrupted
describe
microbiome
rhythmicity
its
related
factors,
highlighting
role
timing.
Lastly,
emphasize
necessity
rationale
further
research
develop
effective
safe
dietary
strategies
based
chrononutrition
combat
Trends in Pharmacological Sciences,
Год журнала:
2023,
Номер
44(10), С. 689 - 704
Опубликована: Авг. 28, 2023
Mood
disorders
account
for
a
significant
global
disease
burden,
and
pharmacological
innovation
is
needed
as
existing
medications
are
suboptimal.
A
wide
range
of
evidence
implicates
circadian
sleep
dysfunction
in
the
pathogenesis
mood
disorders,
there
growing
interest
these
chronobiological
pathways
focus
treatment
innovation.
We
review
contemporary
three
promising
areas
circadian-clock-based
therapeutics
disorders:
targeting
system
informed
by
mechanistic
molecular
advances;
time-tailoring
medications;
personalizing
using
parameters.
also
consider
limitations
challenges
accelerating
development
new
circadian-informed
pharmacotherapies
disorders.
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(4)
Опубликована: Янв. 23, 2025
Sleep
need
accumulates
during
waking
and
dissipates
sleep
to
maintain
homeostasis
(process
S).
Besides
the
regulation
of
daily
(baseline)
amount,
homeostatic
commonly
refers
universal
phenomenon
that
deprivation
(SD)
causes
an
increase
need,
hence,
amount
intensity
subsequent
recovery
sleep.
The
central
regulators
signaling
pathways
govern
baseline
regulations
in
mammals
remain
unclear.
Here,
we
report
enhanced
activity
calcineurin
Aα
(CNAα)—a
catalytic
subunit
calcineurin—in
mouse
brain
neurons
sharply
increases
(to
~17-h/d)
delta
power—a
measure
intensity—of
non–rapid
eye
movement
(NREMS).
Knockout
regulatory
(
CnB1
)
or
CnAα
CnAβ
subunits
diminishes
~4-h/d)
power
NREMS,
but
also
nearly
abrogates
NREMS
following
SD.
Accordingly,
mathematical
modeling
process
S
reveals
inability
accumulate
spontaneous
forced
wakefulness
deficient
mice.
Moreover,
promotes
by
antagonizing
wake-promoting
protein
kinase
A
and,
part,
activating
sleep-promoting
SIK3.
Together,
these
results
indicate
is
important
regulator
governs
both
Communications Biology,
Год журнала:
2025,
Номер
8(1)
Опубликована: Янв. 24, 2025
Recent
genome-wide
association
studies
(GWASs)
of
several
individual
sleep
traits
have
identified
hundreds
genetic
loci,
suggesting
diverse
mechanisms.
Moreover,
are
moderately
correlated,
so
together
may
provide
a
more
complete
picture
health,
while
illuminating
distinct
domains.
Here
we
construct
novel
health
scores
(SHSs)
incorporating
five
core
self-report
measures:
duration,
insomnia
symptoms,
chronotype,
snoring,
and
daytime
sleepiness,
using
additive
(SHS-ADD)
principal
components-based
(SHS-PCs)
approaches.
GWASs
these
six
SHSs
identify
28
significant
loci
adjusting
for
multiple
testing
on
(p
<
8.3e-9),
along
with
341
previously
reported
5e-08).
The
heritability
the
first
three
SHS-PCs
equals
or
exceeds
that
SHS-ADD
(SNP-h2
=
0.094),
revealing
sleep-domain-specific
discoveries.
Significant
enrich
in
brain
tissues
metabolic
neuronal
pathways.
Post-GWAS
analyses
uncover
mechanisms
underlying
reveal
connections
(including
potential
causal
links)
to
behavioral,
psychological,
cardiometabolic
traits.
Data-driven
composite
scores,
combining
self-reported
insomnia,
heritable,
interpretable
phenotypes
GWAS
discoveries
elucidating
regulatory
Proceedings of the Royal Society B Biological Sciences,
Год журнала:
2025,
Номер
292(2041)
Опубликована: Фев. 1, 2025
The
Centers
for
Disease
Control
and
Prevention
declared
sleep-related
problems
to
be
a
public
health
epidemic.
With
the
advent
of
biometric
sleep
tracking
technology
taking
lab
into
field,
study
human
is
now
global,
these
new
datasets
show
contrasting
findings.
Previous
reports
suggest
in
small-scale,
non-industrial
societies
short
fragmented
yet
characterized
by
greater
circadian
rhythmicity.
However,
role
rhythm
indicators
understanding
global
variations
patterns
remains
unclear.
We
examine
population-level
studies
(
n
=
54)
using
polysomnography
actigraphy
test
restriction
epidemic
hypothesis,
which
posits
that
labour
demands
technological
disruption
large-scale,
industrial
have
reduced
duration.
used
an
actigraphy-generated
function
index
from
both
866)
mismatch
suggests
poor
chronohygiene
regulated
environments
misaligns
rhythms
societies.
In
rejection
our
results
experience
longest,
most
efficient
sleep,
whereas
support
sleepers
are
greatest
function.
