The Genetics of Human Sleep and Sleep Disorders DOI
Xianlin Zou, Louis J. Ptáček, Ying‐Hui Fu

et al.

Annual Review of Genomics and Human Genetics, Journal Year: 2024, Volume and Issue: 25(1), P. 259 - 285

Published: April 26, 2024

Healthy sleep is vital for humans to achieve optimal health and longevity. Poor disorders are strongly associated with increased morbidity mortality. However, the importance of good continues be underrecognized. Mechanisms regulating its functions in remain mostly unclear even after decades dedicated research. Advancements gene sequencing techniques computational methodologies have paved way various genetic analysis approaches, which provided some insights into human genetics. This review summarizes our current knowledge basis underlying traits disorders. We also highlight use animal models validate findings from studies discuss potential molecular mechanisms signaling pathways involved regulation sleep.

Language: Английский

Genetics of circadian rhythms and sleep in human health and disease DOI
Jacqueline M. Lane, Jingyi Qian, Emmanuel Mignot

et al.

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 24(1), P. 4 - 20

Published: Aug. 26, 2022

Language: Английский

Citations

134
The translational neuroscience of sleep: A contextual framework DOI
Michael A. Grandner, Fabian‐Xosé Fernandez

Science, Journal Year: 2021, Volume and Issue: 374(6567), P. 568 - 573

Published: Oct. 28, 2021

Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists a social-environmental context. Contextualizing health with respect to its determinants—from individual- societal-level factors—would enable neuroscientists more effectively translate into clinical practice. Key challenges opportunities pertain (i) recognizing exploring sleep’s functional roles, (ii) clarifying causal mechanisms relation key outcomes, (iii) developing richer model systems, (iv) linking models known contextual factors, (v) leveraging advances multisensory technology. Meeting these would help transcend disciplinary boundaries such that considerations related become an ever-greater presence clinic.

Language: Английский

Citations

114
Human circadian variations DOI Open Access
Nicholas W. Gentry, Liza H. Ashbrook, Ying‐Hui Fu

et al.

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(16)

Published: Aug. 15, 2021

Circadian rhythms, present in most phyla across life, are biological oscillations occurring on a daily cycle. Since the discovery of their molecular foundations model organisms, many inputs that modify this tightly controlled system humans have been identified. Polygenic variations and environmental factors influence each person's circadian rhythm, contributing to trait known as chronotype, which manifests degree morning or evening preference an individual. Despite normal variation much society operates "one size fits all" schedule can be difficult adjust to, especially for certain individuals whose endogenous phase is extremely advanced delayed. This public health concern, misalignment associated with number adverse outcomes. Additionally, modern technology (such electric lights computer, tablet, phone screens emit blue light) lifestyles shift irregular work schedules) disrupting consistency increasing people. Though medical lifestyle interventions alleviate some these issues, growing research variability sensitivity suggests broader social changes may necessary minimize impact health.

Language: Английский

Citations

85
Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations DOI Creative Commons
James B. Jaggard, Evan Lloyd,

Anders Yuiska

et al.

Science Advances, Journal Year: 2020, Volume and Issue: 6(38)

Published: Sept. 16, 2020

Environmental perturbation can drive behavioral evolution and associated changes in brain structure function. The Mexican fish species,

Language: Английский

Citations

60
Connecting insufficient sleep and insomnia with metabolic dysfunction DOI
Daisy Duan, Lenise Jihe Kim, Jonathan C. Jun

et al.

Annals of the New York Academy of Sciences, Journal Year: 2022, Volume and Issue: 1519(1), P. 94 - 117

Published: Nov. 13, 2022

Abstract The global epidemic of obesity and type 2 diabetes parallels the rampant state sleep deprivation in our society. Epidemiological studies consistently show an association between insufficient metabolic dysfunction. Mechanistically, circadian rhythm exert considerable influences on hormones involved appetite regulation energy metabolism. As such, data from experimental humans demonstrate that induces a positive balance with resultant weight gain, due to increased intake far exceeds additional expenditure nocturnal wakefulness, adversely impacts glucose Conversely, animal models have found loss–induced caloric resulting net loss. However, significant limitations, which may diminish clinical relevance their findings. Clinically, insomnia disorder symptoms are associated adverse outcomes, though it remains challenging isolate effects outcomes independent comorbidities durations. Furthermore, both pharmacological behavioral interventions for direct effects. goal this review is establish updated framework causal links risks obesity.

Language: Английский

Citations

37
Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal study DOI Creative Commons
Gillian Weston, Afshin Zilanawala, Elizabeth Webb

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 27, 2024

Atypical temporal work patterns such as working longer than the standard 35-40 h/ week, weekend working, and nonstandard schedules (i.e. outside of typical 9-5, including but not restricted to shiftwork) are increasingly prevalent in UK. Aside from occupation-specific studies, little is known about effects these atypical on sleep among workers UK, even though poor has been linked adverse health problems, lower workplace productivity, economic costs.

Language: Английский

Citations

8
Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait DOI Creative Commons
Guangsen Shi, Yin Chen, Zenghua Fan

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 31(1), P. 13 - 24.e4

Published: Oct. 15, 2020

Language: Английский

Citations

42
The prevalence of sleep loss and sleep disorders in young and old adults DOI Creative Commons

Vibha M. Jha

Aging Brain, Journal Year: 2022, Volume and Issue: 3, P. 100057 - 100057

Published: Dec. 19, 2022

The ability to sleep declines with age. National Sleep Foundation, USA has recommended a minimum amount for all ages. Individuals who experience lesser than the could be sleep-deprived. Several factors like stress, altered circadian cycle, medical conditions, etc. cause deficiency. Almost 50-60 % of elderly population suffer from disorders such as apnea, restless legs syndrome, REM behavior disorder, Chronic deprivation may further lead development diseases Alzheimer's and Parkinson's. This paper reviews prevalence consequences loss in young old adults.

Language: Английский

Citations

23
The labour market returns to sleep DOI Creative Commons
Joan Costa‐Font, Sarah Flèche, Ricardo Pagán

et al.

Journal of Health Economics, Journal Year: 2023, Volume and Issue: 93, P. 102840 - 102840

Published: Nov. 20, 2023

Despite the growing prevalence of insufficient sleep among individuals, we still know little about labour market return to sleep. To address this gap, use longitudinal data from Germany and leverage exogenous fluctuations in duration caused by variations time local sunset times. Our findings reveal that a one-hour increase weekly is associated with 1.6 percentage point rise employment 3.4% earnings. Such effect on earnings stems productivity improvements given number working hours decreases longer duration. We also identify key mechanism driving these effects, namely enhanced mental well-being experienced individuals who hours.

Language: Английский

Citations

12
Diverse roles of pontine NPS-expressing neurons in sleep regulation DOI Creative Commons
Lijuan Xing, Xianlin Zou, Yin Chen

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 21, 2024

Neuropeptide S (NPS) was postulated to be a wake-promoting neuropeptide with unknown mechanism, and mutation in its receptor (NPSR1) causes the short sleep duration trait humans. We investigated role of different NPS + nuclei sleep/wake regulation. Loss-of-function chemogenetic studies revealed that neurons parabrachial nucleus (PB) are wake-promoting, whereas peri-locus coeruleus (peri-LC) not important for modulation. Further, we found central gray pons (CGPn) strongly promotes sleep. Fiber photometry recordings showed wake-active CGPn wake/REM-sleep active PB peri-LC. Blocking NPS–NPSR1 signaling or knockdown Nps supported function pathway Together, these results reveal play dichotomous roles regulation at both molecular circuit levels.

Language: Английский

Citations

4