Structured inhibitory activity dynamics in new virtual environments

eLife, Год журнала: 2019, Номер 8

Опубликована: Окт. 8, 2019

Inhibition plays a powerful role in regulating network excitation and plasticity; however, the activity of defined interneuron types during spatial exploration remain poorly understood. Using two-photon calcium imaging, we recorded hippocampal CA1 somatostatin- parvalbumin-expressing interneurons as mice performed goal-directed navigation task new visual virtual reality (VR) contexts. Activity both classes was strongly suppressed but recovered animals learned to adapt previously context. Surprisingly, although there range suppression across population, individual somatostatin-expressing showed consistent levels modulation exposure multiple novel environments, suggesting context-independent, stable roles exploration. This work reveals population-level temporally dynamic within which each shows modulation.

Язык: Английский

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Inhibitory neurons in the superior colliculus mediate selection of spatially-directed movements

Communications Biology, Год журнала: 2021, Номер 4(1)

Опубликована: Июнь 11, 2021

Abstract Decision making is a cognitive process that mediates behaviors critical for survival. Choosing spatial targets an experimentally-tractable form of decision depends on the midbrain superior colliculus (SC). While physiological and computational studies have uncovered functional topographic organization SC, role specific SC cell types in choice unknown. Here, we leveraged behavior, optogenetics, neural recordings modeling to directly examine contribution GABAergic neurons selection opposing targets. Although comprise heterogeneous population with local long-range projections, our results demonstrate do not locally suppress premotor output, suggesting inhibition instead plays dominant choice. An attractor model requiring only intrinsic circuitry was sufficient account experimental observations. Overall, study elucidates

Язык: Английский

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Contribution of non-sensory neurons in visual cortical areas to visually guided decisions in the rat

Current Biology, Год журнала: 2021, Номер 31(13), С. 2757 - 2769.e6

Опубликована: Апрель 22, 2021

It is widely assumed that trial-by-trial variability in visual detection performance explained by the fidelity of responses cortical areas influenced fluctuations internal states, such as vigilance and behavioral history. However, it not clear which neuronal ensembles represent different states. Here, we utilized a task, distinguishes states response to identical stimuli, while recording neurons simultaneously from primary cortex (V1) posterior parietal (PPC). We found rats sometimes withheld their stimuli despite robust presence V1. Our unsupervised analysis revealed distinct population dynamics segregating hit misses, orthogonally embedded both V1 PPC. Heterogeneous non-sensory PPC significantly contributed population-level encoding accompanied with modulation noise correlation only These results highlight non-trivial contributions for computations reflect animals' drive stimuli.

Язык: Английский

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Learning shapes cortical dynamics to enhance integration of relevant sensory input

Neuron, Год журнала: 2022, Номер 111(1), С. 106 - 120.e10

Опубликована: Окт. 24, 2022

Adaptive sensory behavior is thought to depend on processing in recurrent cortical circuits, but how dynamics these circuits shapes the integration and transmission of information not well understood. Here, we study neural coding recurrently connected networks neurons driven by input. We show analytically available network output varies with alignment between feedforward input integrating modes circuit dynamics. In light this theory, analyzed population activity visual cortex mice that learned discriminate features. found over learning, slow patterns realigned better integrate relevant discrimination task. This realignment could be explained changes excitatory-inhibitory connectivity among tuned These results suggest learning tunes temporal optimally

Язык: Английский

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Cognitive experience alters cortical involvement in goal-directed navigation

eLife, Год журнала: 2022, Номер 11

Опубликована: Июнь 23, 2022

Neural activity in the mammalian cortex has been studied extensively during decision tasks, and recent work aims to identify under what conditions is actually necessary for these tasks. We discovered that mice with distinct cognitive experiences, beyond sensory motor learning, use different cortical areas neural patterns solve same navigation task, revealing past learning as a critical determinant of whether goal-directed navigation. used optogenetics calcium imaging study necessity multiple training histories. Posterior parietal retrosplenial were mostly dispensable accurate performance simple task. In contrast, essential task when previously trained on complex tasks delay periods or association switches. Multiarea showed that, complex-task experience, single-neuron had higher selectivity neuron–neuron correlations weaker, leading codes information. Therefore, experience key factor determining have causal role

Язык: Английский

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