Cognitive experience alters cortical involvement in goal-directed navigation DOI Creative Commons
Charlotte Arlt,

Roberto Barroso-Luque,

Shinichiro Kira

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: June 23, 2022

Neural activity in the mammalian cortex has been studied extensively during decision tasks, and recent work aims to identify under what conditions is actually necessary for these tasks. We discovered that mice with distinct cognitive experiences, beyond sensory motor learning, use different cortical areas neural patterns solve same navigation task, revealing past learning as a critical determinant of whether goal-directed navigation. used optogenetics calcium imaging study necessity multiple training histories. Posterior parietal retrosplenial were mostly dispensable accurate performance simple task. In contrast, essential task when previously trained on complex tasks delay periods or association switches. Multiarea showed that, complex-task experience, single-neuron had higher selectivity neuron–neuron correlations weaker, leading codes information. Therefore, experience key factor determining have causal role

Language: Английский

Learning shapes cortical dynamics to enhance integration of relevant sensory input DOI Creative Commons
Angus Chadwick, Adil G. Khan, Jasper Poort

et al.

Neuron, Journal Year: 2022, Volume and Issue: 111(1), P. 106 - 120.e10

Published: Oct. 24, 2022

Adaptive sensory behavior is thought to depend on processing in recurrent cortical circuits, but how dynamics these circuits shapes the integration and transmission of information not well understood. Here, we study neural coding recurrently connected networks neurons driven by input. We show analytically available network output varies with alignment between feedforward input integrating modes circuit dynamics. In light this theory, analyzed population activity visual cortex mice that learned discriminate features. found over learning, slow patterns realigned better integrate relevant discrimination task. This realignment could be explained changes excitatory-inhibitory connectivity among tuned These results suggest learning tunes temporal optimally

Language: Английский

Citations

23
Social odor discrimination and its enhancement by associative learning in the hippocampal CA2 region DOI Creative Commons
Sami Hassan, Shivani Bigler, Steven A. Siegelbaum

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(14), P. 2232 - 2246.e5

Published: May 15, 2023

Language: Английский

Citations

15
Structured inhibitory activity dynamics in new virtual environments DOI Creative Commons
Moisés A. Arriaga, Edward B. Han

eLife, Journal Year: 2019, Volume and Issue: 8

Published: Oct. 8, 2019

Inhibition plays a powerful role in regulating network excitation and plasticity; however, the activity of defined interneuron types during spatial exploration remain poorly understood. Using two-photon calcium imaging, we recorded hippocampal CA1 somatostatin- parvalbumin-expressing interneurons as mice performed goal-directed navigation task new visual virtual reality (VR) contexts. Activity both classes was strongly suppressed but recovered animals learned to adapt previously context. Surprisingly, although there range suppression across population, individual somatostatin-expressing showed consistent levels modulation exposure multiple novel environments, suggesting context-independent, stable roles exploration. This work reveals population-level temporally dynamic within which each shows modulation.

Language: Английский

Citations

41
Contribution of non-sensory neurons in visual cortical areas to visually guided decisions in the rat DOI Creative Commons
Yuma Osako, Tomoya Ohnuki, Yuta Tanisumi

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 31(13), P. 2757 - 2769.e6

Published: April 22, 2021

It is widely assumed that trial-by-trial variability in visual detection performance explained by the fidelity of responses cortical areas influenced fluctuations internal states, such as vigilance and behavioral history. However, it not clear which neuronal ensembles represent different states. Here, we utilized a task, distinguishes states response to identical stimuli, while recording neurons simultaneously from primary cortex (V1) posterior parietal (PPC). We found rats sometimes withheld their stimuli despite robust presence V1. Our unsupervised analysis revealed distinct population dynamics segregating hit misses, orthogonally embedded both V1 PPC. Heterogeneous non-sensory PPC significantly contributed population-level encoding accompanied with modulation noise correlation only These results highlight non-trivial contributions for computations reflect animals' drive stimuli.

Language: Английский

Citations

28
Cognitive experience alters cortical involvement in goal-directed navigation DOI Creative Commons
Charlotte Arlt,

Roberto Barroso-Luque,

Shinichiro Kira

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: June 23, 2022

Neural activity in the mammalian cortex has been studied extensively during decision tasks, and recent work aims to identify under what conditions is actually necessary for these tasks. We discovered that mice with distinct cognitive experiences, beyond sensory motor learning, use different cortical areas neural patterns solve same navigation task, revealing past learning as a critical determinant of whether goal-directed navigation. used optogenetics calcium imaging study necessity multiple training histories. Posterior parietal retrosplenial were mostly dispensable accurate performance simple task. In contrast, essential task when previously trained on complex tasks delay periods or association switches. Multiarea showed that, complex-task experience, single-neuron had higher selectivity neuron–neuron correlations weaker, leading codes information. Therefore, experience key factor determining have causal role

Language: Английский

Citations

20