eNeuro,
Год журнала:
2022,
Номер
9(3), С. ENEURO.0068 - 22.2022
Опубликована: Апрель 18, 2022
Abstract
Understanding
the
long-term
effects
of
stress
on
brain
function
is
crucial
for
understanding
mechanisms
depression.
The
BALB/c
mouse
strain
has
high
susceptibility
to
and
thus
an
effective
model
repeated
social
defeat
(SDS)
mice,
however,
are
not
clear.
Here,
we
investigated
SDS
in
male
mice
over
subsequent
two
weeks.
Some
defeated
immediately
exhibited
avoidance,
whereas
anxiety-like
behavior
was
only
evident
at
later
periods.
Furthermore,
segregated
into
groups
based
level
namely,
avoidant
nonavoidant
mice.
characteristic
avoidance
or
nonavoidance
each
individual
fixed
In
addition,
developed
a
semi-automated
method
analyzing
c-Fos
expression
investigate
effect
activity
more
than
weeks
after
end
exposure.
Following
interaction,
reduced
several
regions
compared
with
control
correlation
among
these
areas,
exception
medial
prefrontal
cortex
(mPFC)
central
amygdala
(CeA),
increased
suggesting
synchrony.
Notably,
lateral
habenula
(LHb)
different
between
that
from
those
These
observations
provide
insight
activity.
Journal of Neural Transmission,
Год журнала:
2023,
Номер
130(9), С. 1133 - 1151
Опубликована: Фев. 14, 2023
Abstract
Neuropsychiatric
disorders,
such
as
major
depression,
anxiety
and
post-traumatic
stress
disorder,
tend
to
be
long-term
conditions
in
whose
development
maintenance
are
central
pathogenic
factors.
Translational
mouse
models
widely
used
neuropsychiatric
research,
exploiting
social
non-social
stressors
investigate
the
mechanisms
underlying
their
detrimental
effects.
However,
most
studies
focus
on
short-term
consequences
of
chronic
stress,
whereas
only
a
few
interested
course.
This
is
counterintuitive
given
human
that
preclinical
designed
mimic.
In
this
review,
we
have
summarized
limited
work
date
effects
mice
models.
First,
different
presented
definition
short-
vs.
sequelae
proposed.
On
basis,
behavioral,
endocrine,
vegetative
addressed
before
examining
data
cellular
molecular
alterations
brain.
Finally,
future
directions
for
research
discussed.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Фев. 11, 2022
Abstract
Optogenetic
methods
provide
efficient
cell-specific
modulations,
and
the
ability
of
simultaneous
neural
activation
inhibition
in
same
brain
region
freely
moving
animals
is
highly
desirable.
Here
we
report
bidirectional
neuronal
activity
manipulation
accomplished
by
a
wireless,
dual-color
optogenetic
probe
synergy
with
co-expression
two
spectrally
distinct
opsins
(ChrimsonR
stGtACR2)
rodent
model.
The
flexible
comprises
vertically
assembled,
thin-film
microscale
light-emitting
diodes
lateral
dimension
125
×
180
µm
2
,
showing
colocalized
red
blue
emissions
enabling
chronic
vivo
operations
desirable
biocompatibilities.
Red
or
irradiations
deterministically
evoke
silence
neurons
co-expressing
opsins.
interferes
dopaminergic
ventral
tegmental
area
mice,
increasing
decreasing
dopamine
levels.
Such
regulations
further
generate
rewarding
aversive
behaviors
interrogate
social
interactions
among
multiple
mice.
These
technologies
create
numerous
opportunities
implications
for
research.
Journal of Neuroscience,
Год журнала:
2021,
Номер
41(12), С. 2645 - 2655
Опубликована: Фев. 9, 2021
The
ability
to
recognize
motivationally
salient
events
and
adaptively
respond
them
is
critical
for
survival.
Here,
we
tested
whether
dopamine
(DA)
neurons
in
the
dorsal
raphe
nucleus
(DRN)
contribute
this
process
both
male
female
mice.
Population
recordings
of
DRN
DA
during
associative
learning
tasks
showed
that
their
activity
dynamically
tracks
motivational
salience,
developing
excitation
reward-paired
shock-paired
cues.
response
reward-predicting
cues
was
diminished
after
satiety,
suggesting
modulation
by
internal
states.
also
greater
unexpected
outcomes
than
expected
outcomes.
Two-photon
imaging
demonstrated
majority
individual
developed
activation
reward
but
not
shock-predicting
cues,
which
surprising
qualitatively
distinct
from
population
results.
Performing
same
fear
procedures
freely-moving
head-fixed
groups
revealed
head-fixation
itself
abolished
neural
aversive
indicating
its
behavioral
context.
Overall,
these
results
suggest
encode
dependent
on
external
factors.
SIGNIFICANCE
STATEMENT
Dopamine
contributes
control,
composed
at
least
two
functional
cell
types,
one
signaling
value
another
salience.
demonstrate
salience
tasks.
Neural
responses
were
dynamic
modulated
animal's
state.
single-cells
or
paired
Additional
experiments
with
mice
development
cue
learning.
This
work
provides
further
characterization
roles
overlooked
populations
an
example
can
be
altered
head-fixation,
commonly
used
neuroscience.
