Long-Term Effects of Repeated Social Defeat Stress on Brain Activity during Social Interaction in BALB/c Mice DOI Creative Commons

Hibiki Okamura,

Shinnosuke Yasugaki,

Haruka Suzuki-Abe

et al.

eNeuro, Journal Year: 2022, Volume and Issue: 9(3), P. ENEURO.0068 - 22.2022

Published: April 18, 2022

Abstract Understanding the long-term effects of stress on brain function is crucial for understanding mechanisms depression. The BALB/c mouse strain has high susceptibility to and thus an effective model repeated social defeat (SDS) mice, however, are not clear. Here, we investigated SDS in male mice over subsequent two weeks. Some defeated immediately exhibited avoidance, whereas anxiety-like behavior was only evident at later periods. Furthermore, segregated into groups based level namely, avoidant nonavoidant mice. characteristic avoidance or nonavoidance each individual fixed In addition, developed a semi-automated method analyzing c-Fos expression investigate effect activity more than weeks after end exposure. Following interaction, reduced several regions compared with control correlation among these areas, exception medial prefrontal cortex (mPFC) central amygdala (CeA), increased suggesting synchrony. Notably, lateral habenula (LHb) different between that from those These observations provide insight activity.

Language: Английский

Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators DOI
Zhaofa Wu, Dayu Lin, Yulong Li

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(5), P. 257 - 274

Published: March 31, 2022

Language: Английский

Citations

163
A chemically mediated artificial neuron DOI
Ting Wang, Ming Wang, Jianwu Wang

et al.

Nature Electronics, Journal Year: 2022, Volume and Issue: 5(9), P. 586 - 595

Published: Aug. 8, 2022

Language: Английский

Citations

114
Development, wiring and function of dopamine neuron subtypes DOI
Oxana Garritsen, Eljo Y. van Battum,

Laurens M. Grossouw

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(3), P. 134 - 152

Published: Jan. 18, 2023

Language: Английский

Citations

72
Long-term effects of chronic stress models in adult mice DOI Creative Commons
Inès Tran, Anne‐Kathrin Gellner

Journal of Neural Transmission, Journal Year: 2023, Volume and Issue: 130(9), P. 1133 - 1151

Published: Feb. 14, 2023

Abstract Neuropsychiatric disorders, such as major depression, anxiety and post-traumatic stress disorder, tend to be long-term conditions in whose development maintenance are central pathogenic factors. Translational mouse models widely used neuropsychiatric research, exploiting social non-social stressors investigate the mechanisms underlying their detrimental effects. However, most studies focus on short-term consequences of chronic stress, whereas only a few interested course. This is counterintuitive given human that preclinical designed mimic. In this review, we have summarized limited work date effects mice models. First, different presented definition short- vs. sequelae proposed. On basis, behavioral, endocrine, vegetative addressed before examining data cellular molecular alterations brain. Finally, future directions for research discussed.

Language: Английский

Citations

51
Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors DOI Creative Commons
Waylin Yu, Dipanwita Pati, Melanie M. Pina

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(8), P. 1365 - 1380.e5

Published: March 19, 2021

Language: Английский

Citations

98
Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe DOI Creative Commons
Lizhu Li,

Lihui Lu,

Yuqi Ren

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Feb. 11, 2022

Abstract Optogenetic methods provide efficient cell-specific modulations, and the ability of simultaneous neural activation inhibition in same brain region freely moving animals is highly desirable. Here we report bidirectional neuronal activity manipulation accomplished by a wireless, dual-color optogenetic probe synergy with co-expression two spectrally distinct opsins (ChrimsonR stGtACR2) rodent model. The flexible comprises vertically assembled, thin-film microscale light-emitting diodes lateral dimension 125 × 180 µm 2 , showing colocalized red blue emissions enabling chronic vivo operations desirable biocompatibilities. Red or irradiations deterministically evoke silence neurons co-expressing opsins. interferes dopaminergic ventral tegmental area mice, increasing decreasing dopamine levels. Such regulations further generate rewarding aversive behaviors interrogate social interactions among multiple mice. These technologies create numerous opportunities implications for research.

Language: Английский

Citations

65
A common thalamic hub for general and defensive arousal control DOI Creative Commons
Yiwei Wang,

Ling You,

KaMun Tan

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(20), P. 3270 - 3287.e8

Published: Aug. 8, 2023

Language: Английский

Citations

25
The resting-state brain activity signatures for addictive disorders DOI Creative Commons
Hui Zheng, Tianye Zhai, Xiao Lin

et al.

Med, Journal Year: 2024, Volume and Issue: 5(3), P. 201 - 223.e6

Published: Feb. 14, 2024

Language: Английский

Citations

11
A brainstem circuit amplifies aversion DOI

Jingwen Liang,

Yu Zhou,

Qiru Feng

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(21), P. 3634 - 3650.e5

Published: Sept. 12, 2024

Language: Английский

Citations

9
Dorsal Raphe Dopamine Neurons Signal Motivational Salience Dependent on Internal State, Expectation, and Behavioral Context DOI Creative Commons
Jounhong Ryan Cho, Xinhong Chen, Anat Kahan

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(12), P. 2645 - 2655

Published: Feb. 9, 2021

The ability to recognize motivationally salient events and adaptively respond them is critical for survival. Here, we tested whether dopamine (DA) neurons in the dorsal raphe nucleus (DRN) contribute this process both male female mice. Population recordings of DRN DA during associative learning tasks showed that their activity dynamically tracks motivational salience, developing excitation reward-paired shock-paired cues. response reward-predicting cues was diminished after satiety, suggesting modulation by internal states. also greater unexpected outcomes than expected outcomes. Two-photon imaging demonstrated majority individual developed activation reward but not shock-predicting cues, which surprising qualitatively distinct from population results. Performing same fear procedures freely-moving head-fixed groups revealed head-fixation itself abolished neural aversive indicating its behavioral context. Overall, these results suggest encode dependent on external factors. SIGNIFICANCE STATEMENT Dopamine contributes control, composed at least two functional cell types, one signaling value another salience. demonstrate salience tasks. Neural responses were dynamic modulated animal's state. single-cells or paired Additional experiments with mice development cue learning. This work provides further characterization roles overlooked populations an example can be altered head-fixation, commonly used neuroscience.

Language: Английский

Citations

46