Selective manipulation of excitatory and inhibitory neurons in top-down and bottom-up visual pathways using ultrasound stimulation DOI Creative Commons
Yehhyun Jo, Xiaoli Liang,

Hong Phuong Nguyen

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Techniques for precise manipulation of neurons in specific neural pathways are crucial excitatory/inhibitory (E/I) balance and investigation complex brain circuits. Low-intensity focused ultrasound stimulation (LIFUS) has emerged as a promising tool noninvasive deep-brain targeting at high spatial resolution. However, there is lack studies that extensively investigate the modulation top-down bottom-up corticothalamic circuits via selective excitatory inhibitory neurons. Here, comprehensive methodology using electrophysiological recording c-Fos staining employed to demonstrate pulse repetition frequency (PRF)-dependent E/I selectivity visual circuit rodents. Ultrasound various PRFs applied either lateral posterior nucleus thalamus (LP) or primary cortex (V1), multi-channel single-unit activity recorded from V1 silicon probe. Our results high-frequency PRFs, particularly 3 kHz 1 kHz, effective activating bidirectional pathway. In addition, region-specific modulate cortical signals, projections, synaptic neurotransmission, which imperative circuit-specific applications behavioral studies.

Language: Английский

Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle DOI
Gordon M. Shepherd, Naoki Yamawaki

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(7), P. 389 - 406

Published: May 6, 2021

Language: Английский

Citations

189
Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations DOI Creative Commons
Dennis Nestvogel, David A. McCormick

Neuron, Journal Year: 2021, Volume and Issue: 110(1), P. 120 - 138.e4

Published: Oct. 22, 2021

Language: Английский

Citations

77
Neuroscience and architecture: Modulating behavior through sensorimotor responses to the built environment DOI Creative Commons
Zakaria Djebbara, Ole B. Jensen, Francisco J. Parada

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 138, P. 104715 - 104715

Published: May 30, 2022

As we move through the world, natural and built environments implicitly guide behavior by appealing to certain sensory motor dynamics. This process can be motivated automatic attention environmental features that resonate with specific sensorimotor responses. review aims at providing a psychobiological framework describing how lead automated responses defined neurophysiological mechanisms underlying attention. Through use of processes in subsets cortical structures, goal this is describe on neuronal level functional link between designed environment By distinguishing elaborate employs for adaptation. realized thalamo-cortical network integrating aspects behavior. We highlight transthalamic transmission from an Enactive predictive perspective recent studies effectively modulated systematically manipulating features. end suggesting promising combination neuroimaging computational analysis future studies.

Language: Английский

Citations

43
On natural attunement: Shared rhythms between the brain and the environment DOI Creative Commons
Efrosini Charalambous, Zakaria Djebbara

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 155, P. 105438 - 105438

Published: Oct. 27, 2023

Rhythms exist both in the embodied brain and built environment. Becoming attuned to rhythms of environment, such as repetitive columns, can greatly affect perception. Here, we explore how environment affects human cognition behavior through concept natural attunement, often resulting from coordination a person's sensory motor systems with rhythmic elements We argue that should not be reduced mere states, representations, single variables but instead considered bundle highly related continuous signals which resonate. Resonance entrainment are dynamic processes observed when intrinsic frequencies oscillatory influenced by oscillations an external signal. This allows visual stimulations body neural entrainment, cross-frequency coupling, phase resetting. review real-world architectural settings dynamics, cognitive processes, people, suggesting crucial role everyday brain-body-environment relationship.

Language: Английский

Citations

25
Cooperative thalamocortical circuit mechanism for sensory prediction errors DOI Creative Commons

Shohei Furutachi,

Alexis D. Franklin, Andreea M. Aldea

et al.

Nature, Journal Year: 2024, Volume and Issue: 633(8029), P. 398 - 406

Published: Aug. 28, 2024

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance prediction-error signals for various neural computations across brain, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory that required generating sensory in mouse primary visual cortex (V1). We show violating animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction errors specifically amplify input, rather than representing non-specific surprise or difference how input deviates from animal’s predictions. This amplification implemented cooperative mechanism requiring thalamic pulvinar cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing interneurons gate excitatory V1, resulting pulvinar-driven stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Language: Английский

Citations

17
MSV-net: Multi-scale visual-inspired network for short-term electricity price forecasting DOI
Han Wu, Yan Liang, Jiani Heng

et al.

Energy, Journal Year: 2024, Volume and Issue: 291, P. 130350 - 130350

Published: Jan. 21, 2024

Language: Английский

Citations

9
Control and recalibration of path integration in place cells using optic flow DOI
Manu S. Madhav, Ravikrishnan P. Jayakumar, Brian Li

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(8), P. 1599 - 1608

Published: June 27, 2024

Language: Английский

Citations

9
Corticothalamic Pathways in Auditory Processing: Recent Advances and Insights From Other Sensory Systems DOI Creative Commons
Flora M. Antunes, Manuel S. Malmierca

Frontiers in Neural Circuits, Journal Year: 2021, Volume and Issue: 15

Published: Aug. 19, 2021

The corticothalamic (CT) pathways emanate from either Layer 5 (L5) or 6 (L6) of the neocortex and largely outnumber ascending, thalamocortical pathways. CT provide anatomical foundations for an intricate, bidirectional communication between thalamus cortex. They act as dynamic circuits information transfer with ability to modulate even drive response properties target neurons at each synaptic node circuit. L6 feedback enable cortex shape nature its driving inputs, by directly modulating sensory message arriving thalamus. L5 can postsynaptic initiate a transthalamic corticocortical circuit which cortical areas communicate other. For this reason, place heart through hierarchy. Recent evidence goes further suggest that via regulates functional connectivity within across regions, might be engaged in cognition, behavior, perceptual inference. As descending reciprocal context-dependent cortex, we venture projections are particularly interesting context hierarchical inference formulations such those contemplated predictive processing schemes, so far heavily rely on implementations. We discuss recent proposals suggesting thalamus, higher order pathways, could coordinate contextualize hierarchies. will explore these ideas focus auditory system.

Language: Английский

Citations

55
Cortical-subcortical interactions in goal-directed behavior DOI
K. Guadalupe Cruz,

Yi Ning Leow,

Nhat Minh Le

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(1), P. 347 - 389

Published: June 30, 2022

Flexibly selecting appropriate actions in response to complex, ever-changing environments requires both cortical and subcortical regions, which are typically described as participating a strict hierarchy. In this traditional view, highly specialized circuits allow for efficient responses salient stimuli, at the cost of adaptability context specificity, attributed neocortex. Their interactions often cortex providing top-down command signals structures implement; however, available technologies develop, studies increasingly demonstrate that behavior is represented by brainwide activity even contain early choice, suggesting behavioral functions emerge result different regions interacting truly collaborative networks. review, we discuss field’s evolving understanding how placental mammals interact cooperatively, not only via cortical-subcortical inputs but through bottom-up interactions, especially thalamus. We describe our current circuitry two exemplar structures, superior colliculus striatum, identify information prioritized regions. then functional these form with one another, thalamus, create parallel loops complex networks flow. Finally, challenge classic view modules contained within specific brain regions; instead, propose certain prioritize types over others, subnetworks they form, defined their anatomical connections dynamics, basis true specialization.

Language: Английский

Citations

32
Brain‐wide mapping of inputs to the mouse lateral posterior (LP/Pulvinar) thalamus–anterior cingulate cortex network DOI

Yi Ning Leow,

Blake Zhou, Heather A. Sullivan

et al.

The Journal of Comparative Neurology, Journal Year: 2022, Volume and Issue: 530(11), P. 1992 - 2013

Published: April 6, 2022

Abstract The rodent homolog of the primate pulvinar, lateral posterior (LP) thalamus, is extensively interconnected with multiple cortical areas. While these interactions can span entire LP, subdivisions LP are characterized by differential connections specific regions. In particular, medial has reciprocal frontoparietal areas, including anterior cingulate cortex (ACC). ACC plays an integral role in top‐down sensory processing and attentional regulation, likely exerting some functions via LP. However, little known about how interact, information potentially integrated this network. Here, we address gap employing a projection‐specific monosynaptic rabies tracing strategy to delineate brain‐wide inputs bottom‐up LP→ACC ACC→LP neurons. We find that neurons receive from widespread regions, primary higher order motor also extensive subcortical inputs, particularly intermediate deep layers superior colliculus (SC). Sensory largely arise visual addition, integrate cross‐hemispheric prefrontal as well cortex. Our anatomical mapping LP‐ACC pathways provides roadmap for understanding communicate different sources mediate control visuomotor functions.

Language: Английский

Citations

31