Long-range inhibition from prelimbic to cingulate areas of the medial prefrontal cortex enhances network activity and response execution DOI Creative Commons
Nao Utashiro, Duncan A. A. MacLaren, Yu‐Chao Liu

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 10, 2024

Abstract It is well established that the medial prefrontal cortex (mPFC) exerts top-down control of many behaviors, but little known regarding how cross-talk between distinct areas mPFC influences signaling. We performed virus-mediated tracing and functional studies in male mice, homing on GABAergic projections whose axons are located mainly layer 1 connect two mPFC, namely prelimbic area (PrL) with cingulate 2 (Cg1/2). revealed identity targeted neurons comprise types interneurons, single-bouquet cells (SBCs) neurogliaform (NGFs), propose this connectivity links projection cortical canonical circuits. In vitro electrophysiological vivo calcium imaging support notion from PrL to Cg1/2 exert a crucial role regulating activity target by disinhibiting 5 output neurons. Finally, we demonstrated recruitment these affects impulsivity mechanical responsiveness, behaviors which be modulated activity.

Язык: Английский

Early Alzheimer’s disease pathology in human cortex involves transient cell states DOI Creative Commons
Vahid Gazestani, Tushar Kamath, Naeem Nadaf

и другие.

Cell, Год журнала: 2023, Номер 186(20), С. 4438 - 4453.e23

Опубликована: Сен. 1, 2023

Язык: Английский

Процитировано

113
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex DOI
Thomas Chartrand, Rachel Dalley, Jennie Close

и другие.

Science, Год журнала: 2023, Номер 382(6667)

Опубликована: Окт. 12, 2023

Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion human neocortex marked by distinctive pyramidal neurons with extensive L1 branching, but whether interneurons are similarly diverse underexplored. Using Patch-seq recordings from neurosurgical tissue, we identified four transcriptomic subclasses mouse homologs, along distinct subtypes types unmatched in L1. Subclass subtype comparisons showed stronger differences were correlated strong morphoelectric variability dimensions variability. Accompanied greater thickness other cytoarchitecture changes, these findings suggest that has diverged evolution, reflecting the demands regulating expanded neocortical circuit.

Язык: Английский

Процитировано

58
Cortico-cortical feedback engages active dendrites in visual cortex DOI Creative Commons

Mehmet Fişek,

Dustin Herrmann, Alexander Egea-Weiss

и другие.

Nature, Год журнала: 2023, Номер 617(7962), С. 769 - 776

Опубликована: Май 3, 2023

Abstract Sensory processing in the neocortex requires both feedforward and feedback information flow between cortical areas 1 . In processing, higher-level representations provide contextual to lower levels, facilitate perceptual functions such as contour integration figure–ground segmentation 2,3 However, we have limited understanding of circuit cellular mechanisms that mediate influence. Here use long-range all-optical connectivity mapping mice show influence from lateromedial higher visual area (LM) primary cortex (V1) is spatially organized. When source target represent same space, relatively suppressive. By contrast, when offset facilitating. Two-photon calcium imaging data this facilitating nonlinearly integrated apical tuft dendrites V1 pyramidal neurons: retinotopically (surround) stimuli drive local dendritic signals indicative regenerative events, two-photon optogenetic activation LM neurons projecting identified feedback-recipient spines can similar branch-specific signals. Our results how neocortical nonlinear together form a substrate support predictive cooperative interactions.

Язык: Английский

Процитировано

45
Contribution of behavioural variability to representational drift DOI Creative Commons
Sadra Sadeh, Claudia Clopath

eLife, Год журнала: 2022, Номер 11

Опубликована: Авг. 30, 2022

Neuronal responses to similar stimuli change dynamically over time, raising the question of how internal representations can provide a stable substrate for neural coding. Recent work has suggested large degree drift in even sensory cortices, which are believed store external world. While these is mostly characterized relation stimuli, behavioural state animal (for instance, level arousal) also known strongly modulate activity. We therefore asked variability such modulatory mechanisms contribute representational changes. analysed large-scale recording activity from Allen Brain Observatory, was used before document mouse visual cortex. found that, within datasets, significantly contributes This effect broadcasted across various cortical areas mouse, including primary cortex, higher order areas, and regions not primarily linked vision like hippocampus. Our computational modelling suggests that results consistent with independent modulation by behaviour slower timescales. Importantly, our analysis reliable but variable be misinterpreted as if neuronal only stimulus space marginalized parameters.

Язык: Английский

Процитировано

54
Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types DOI
Madhuvanthi Kannan, Ganesh Vasan, Simon Haziza

и другие.

Science, Год журнала: 2022, Номер 378(6619)

Опубликована: Ноя. 3, 2022

Genetically encoded fluorescent voltage indicators are ideally suited to reveal the millisecond-scale interactions among and between targeted cell populations. However, current lack requisite sensitivity for in vivo multipopulation imaging. We describe next-generation green red sensors, Ace-mNeon2 VARNAM2, their reverse response-polarity variants pAce pAceR. Our enable 0.4- 1-kilohertz recordings from >50 spiking neurons per field of view awake mice ~30-minute continuous imaging flies. Using dual-polarity multiplexed imaging, we uncovered brain state-dependent antagonism neocortical somatostatin-expressing (SST+) vasoactive intestinal peptide-expressing (VIP+) interneurons contributions hippocampal potentials ensembles with distinct axonal projections. By combining three mutually compatible indicators, performed simultaneous triple-population These approaches will empower investigations dynamic interplay neuronal subclasses at single-spike resolution.

Язык: Английский

Процитировано

54
The locus coeruleus as a global model failure system DOI Creative Commons
Rebecca Jordan

Trends in Neurosciences, Год журнала: 2023, Номер 47(2), С. 92 - 105

Опубликована: Дек. 14, 2023

Predictive processing models posit that brains constantly attempt to predict their sensory inputs. Prediction errors signal when these predictions are incorrect and thought be instructive signals drive corrective plasticity. Recent findings support the idea locus coeruleus (LC) - a brain-wide neuromodulatory system several types of prediction error. I discuss how proposing LC global model failures: instances where about world strongly violated. Focusing on cortex, explore utility this in learning rate control, circuit may compute signal, view aid our understanding neurodivergence.

Язык: Английский

Процитировано

31
Layer 1 NDNF interneurons are specialized top-down master regulators of cortical circuits DOI Creative Commons
Jan Hartung, Anna Schroeder,

Rodrigo Alejandro Péréz Vázquez

и другие.

Cell Reports, Год журнала: 2024, Номер 43(5), С. 114212 - 114212

Опубликована: Май 1, 2024

Diverse types of inhibitory interneurons (INs) impart computational power and flexibility to neocortical circuits. Whereas markers for different IN in cortical layers 2-6 (L2-L6) have been instrumental generating a wealth functional insights, only the recent identification selective marker (neuron-derived neurotrophic factor [NDNF]) has opened comparable opportunities INs L1 (L1INs). However, at present we know very little about connectivity NDNF L1INs with other types, their input-output conversion, existence potential L1IN subtypes. Here, report pervasive inhibition L2/3 (including parvalbumin vasoactive intestinal peptide INs) by L1INs. Intersectional genetics revealed similar physiology subpopulation co-expressing neuropeptide Y. Finally, prominently selectively engage persistent firing, physiological hallmark disconnecting output from current input. Collectively, our work therefore identifies as specialized master regulators superficial neocortex according top-down afferents.

Язык: Английский

Процитировано

15
The organization and development of cortical interneuron presynaptic circuits are area specific DOI Creative Commons
Gabrielle Pouchelon, Deepanjali Dwivedi, Yannick Bollmann

и другие.

Cell Reports, Год журнала: 2021, Номер 37(6), С. 109993 - 109993

Опубликована: Ноя. 1, 2021

Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are genetically invariant thought to form canonical circuits regardless of which area they embedded in. Here, we investigate whether this is achieved through selective systematic variations their afferent connectivity during development. To end, examined development inputs within distinct areas. We find afferents show little evidence being globally stereotyped. Rather, each subtype displays characteristic regional developmental dynamics by achieved. Moreover, dynamically regulated disrupted early deprivation a model fragile X syndrome. These data provide comprehensive map across reveal logic these established

Язык: Английский

Процитировано

51
Bottom-up inputs are required for establishment of top-down connectivity onto cortical layer 1 neurogliaform cells DOI Creative Commons
Leena A. Ibrahim, Shuhan Huang, Marian Fernández-Otero

и другие.

Neuron, Год журнала: 2021, Номер 109(21), С. 3473 - 3485.e5

Опубликована: Сен. 2, 2021

Язык: Английский

Процитировано

47
Single genomic enhancers drive experience-dependent GABAergic plasticity to maintain sensory processing in the adult cortex DOI Creative Commons

Ori Roethler,

Eran Zohar,

Katayun Cohen-Kashi Malina

и другие.

Neuron, Год журнала: 2023, Номер 111(17), С. 2693 - 2708.e8

Опубликована: Июнь 24, 2023

Experience-dependent plasticity of synapses modulates information processing in neural circuits and is essential for cognitive functions. The genome, via non-coding enhancers, was proposed to control circuit by regulating experience-induced transcription genes that modulate specific sets synapses. To test this idea, we analyze here the cellular functions genomic mechanisms Igf1 (insulin-like growth factor 1) vasoactive intestinal peptide (VIP) interneurons (INs) visual cortex adult mice. We find two sensory-induced enhancers selectively cooperatively drive activity-induced thereby promote GABAergic inputs onto VIP INs homeostatically ratio between excitation inhibition (E/I ratio)-in turn, restricts activity principal excitatory neurons maintains spatial frequency tuning. Thus, enhancer-mediated sensory homeostatic modulation E/I ratio.

Язык: Английский

Процитировано

19