Network pharmacology approaches for research of Traditional Chinese Medicines

Chinese Journal of Natural Medicines, Год журнала: 2023, Номер 21(5), С. 323 - 332

Опубликована: Май 1, 2023

Язык: Английский

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Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine

Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 34(3), С. 146 - 157

Опубликована: Янв. 28, 2023

Язык: Английский

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Dendrobium huoshanense in the treatment of ulcerative colitis: Network pharmacology and experimental validation

Journal of Ethnopharmacology, Год журнала: 2024, Номер 323, С. 117729 - 117729

Опубликована: Янв. 7, 2024

Dendrobium huoshanense C. Z. Tang et S. J. Cheng (DH) is a traditional medicinal herb with long history of use. DH has been recorded as protecting the gastrointestinal function. Modern pharmacology research shows that regulates intestinal flora, mucosal immunity, peristalsis and secretion digestive juices. At same time, some studies have shown good therapeutic effect on ulcerative colitis, but its mechanism action not fully elucidated.

Язык: Английский

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Efficacy and mechanism of the Ermiaosan Series of Formulas for rheumatoid arthritis based on chinmedomics strategy

Phytomedicine, Год журнала: 2024, Номер 132, С. 155903 - 155903

Опубликована: Июль 22, 2024

Язык: Английский

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Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis

Phytomedicine, Год журнала: 2024, Номер 129, С. 155510 - 155510

Опубликована: Март 11, 2024

Язык: Английский

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Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds

Pharmacology & Therapeutics, Год журнала: 2021, Номер 224, С. 107824 - 107824

Опубликована: Март 2, 2021

Язык: Английский

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Classification-based strategies to simplify complex traditional Chinese medicine (TCM) researches through liquid chromatography-mass spectrometry in the last decade (2011–2020): Theory, technical route and difficulty

Journal of Chromatography A, Год журнала: 2021, Номер 1651, С. 462307 - 462307

Опубликована: Июнь 4, 2021

Язык: Английский

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Version updates of strategies for drug discovery based on effective constituents of traditional Chinese medicine

Acupuncture and Herbal Medicine, Год журнала: 2023, Номер 3(3), С. 158 - 179

Опубликована: Июль 3, 2023

The discovery of effective constituents traditional Chinese medicine (TCM) is an important approach in new drug development. Several well-known drugs, such as artemisinin, berberine, and ephedrine have been developed using this approach. However, the efficacy safety TCM, two key issues for development based on TCM clinical experience, remain unclear worldwide. strategy relevant most step determining safety, which still a scientific problem that restricts drugs. Furthermore, formulas used drugs address specific syndrome ( Zheng ), complexity formula vagueness make identification related to effectiveness challenging. Over decades, researchers transdisciplinary technologies research methodologies identify vivo . In paper, history identifying reviewed summarized. main approaches include phytochemical method, involves classical systematic separation screening (extraction, separation, purification, structure identification, activity test); bioactivity-guided separation; serum pharmacochemistry ; Chinmedomics, connects with biomarkers syndrome. Chinmedomics promising conforms theory characteristics TCM. By clarifying constituents, targets pathways medicines, it can promote lead compounds innovative continuously modernization Graphical abstract: http://links.lww.com/AHM/A64.

Язык: Английский

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Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

Frontiers in Chemistry, Год журнала: 2023, Номер 11

Опубликована: Март 31, 2023

Natural products derived from herbal medicine are a fruitful source of lead compounds because their structural diversity and potent bioactivities. However, despite the success active in drug discovery, some approaches cannot effectively elucidate overall effect action mechanism due to multi-component complexity. Fortunately, mass spectrometry-based metabolomics has been recognized as an effective strategy for revealing discovering components, detailed molecular mechanisms, multiple targets natural products. Rapid identification isolation components would facilitate new development. In this context, established integrated pharmacology framework discovery bioactivity-correlated constituents, target identification, High-throughput functional techniques could be used identify product structure, biological activity, efficacy mode on processes, assisting bioactive quality control, accelerating novel drugs. These increasingly being developed era big data use scientific language clarify medicine. paper, analytical characteristics application fields several commonly spectrometers introduced, spectrometry traditional Chinese medicines recent years its well also discussed.

Язык: Английский

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Advanced applications of mass spectrometry imaging technology in quality control and safety assessments of traditional Chinese medicines

Journal of Ethnopharmacology, Год журнала: 2021, Номер 284, С. 114760 - 114760

Опубликована: Окт. 22, 2021

Язык: Английский

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