Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 23, 2024
Traditional
Chinese
medicine
(TCM)
is
the
practical
experience
and
summary
of
nation
for
thousands
years.
It
shows
great
potential
in
treating
various
chronic
diseases,
complex
diseases
major
infectious
has
gradually
attracted
attention
people
all
over
world.
However,
due
to
complexity
prescription
action
mechanism
TCM,
development
TCM
industry
still
a
relatively
conservative
stage.
With
rise
artificial
intelligence
technology
fields,
many
scholars
began
apply
traditional
made
remarkable
progress.
This
paper
comprehensively
summarizes
important
role
from
aspects,
including
new
drug
discovery,
data
mining,
quality
standardization
medicine.
The
limitations
these
applications
are
also
emphasized,
lack
pharmacological
research,
database
problems
challenges
brought
by
human-computer
interaction.
Nevertheless,
opportunities
innovations
modernization
Integrating
into
comprehensive
application
expected
overcome
faced
further
promote
whole
industry.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 17, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
clinicopathological
syndrome
characterized
by
abnormalities
in
hepatic
fat
deposition,
the
incidence
of
which
has
been
increasing
year
recent
years.
It
become
largest
chronic
globally
and
one
important
causes
cirrhosis
even
primary
cancer
formation.
The
pathogenesis
NAFLD
not
yet
fully
clarified.
Modern
medicine
lacks
targeted
clinical
treatment
protocols
for
NAFLD,
most
drugs
lack
efficacy
have
high
side
effects.
In
contrast,
Traditional
Chinese
Medicine
(TCM)
significant
advantages
prevention
widely
recognized
scholars
around
world.
years,
through
establishment
"medicine-disease-target-pathway"
network
relationship,
pharmacology
can
explore
molecular
basis
role
medicines
from
various
perspectives,
predicting
pharmacological
mechanism
corresponding
medicines.
This
approach
compatible
with
holistic
view
based
on
pattern
differentiation
TCM
used
research.
this
paper,
searching
relevant
databases
such
as
PubMed,
Web
Science,
Embase,
we
reviewed
analyzed
signaling
pathways
specific
mechanisms
action
single
medicine,
combinations,
patent
These
related
studies
demonstrated
therapeutic
characteristics
multi-components,
multi-targets,
multi-pathways,
provided
strong
support
exact
exerted
clinic.
conclusion,
believe
that
more
line
mindset
treating
diseases,
but
some
limitations.
future,
should
eliminate
potential
risks
false
positives
negatives,
clarify
interconnectivity
between
components,
targets,
conduct
deeper
or
experimental
studies.
Biomedical Chromatography,
Год журнала:
2025,
Номер
39(2)
Опубликована: Янв. 2, 2025
The
objective
of
this
study
is
to
comprehensively
identify
the
core
pharmacological
components
and
their
respective
targets
three
medicinal
fungi
Sanghuangs
including
Sanghuangporus
vaninii
(SV),
lonicericola
(SL),
Inonotus
hispidus
(IH).
Metabolomics
analysis
indicated
that
a
total
495
660
differential
metabolites
were
obtained
in
mycelium
fermentation
broth
samples
among
Sanghuangs,
respectively.
network
pharmacology
showed
6-[1]-ladderane
hexanol,
R-nostrenol,
candidone,
ellagic
acid,
quercetin
overlapping
active
ingredients
Sanghuang
species
for
diabetes
mellitus,
immune
system
disease,
neoplasm.
Certonardosterol
A,
dalamid,
ethylene
brassylate
are
unique
SV,
certonardosterol
K,
kaempferide,
esculetin
SL.
Asbestinine,
neoandrographolide,
isosakuranetin,
daucosterin
IH.
Accordingly,
common
ESR1,
PIK3CA,
LYN.
PRKCA,
EGFR,
STAT3
SL,
IH,
primary
targets,
addition
component-target
interaction
have
been
identified
present
study,
provide
foundation
future
research
on
prevention
treatment
disease
using
Sanghuangs.
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 185 - 200
Опубликована: Янв. 1, 2025
Abstract:
Cerebral
ischemia-reperfusion
injury
(CIRI)
is
clinically
characterized
by
high
rates
of
morbidity,
disability,
mortality,
and
recurrence
as
well
economic
burden.
The
clinical
manifestations
CIRI
are
often
accompanied
gastrointestinal
symptoms
such
intestinal
bacterial
dysbiosis
bleeding.
Gut
microbiota
plays
an
important
role
in
the
pathogenesis
CIRI,
its
potential
biological
effects
have
received
extensive
attention.
gut
not
only
affects
barrier
function
but
also
regulates
immunity
host
homeostasis.
Traditional
Chinese
medicine
(TCM),
a
multi-component
multi-targeted
drug,
has
shown
remarkable
few
adverse
reactions
prevention
treatment
CIRI.
Notably,
effect
TCM
on
regulating
maintaining
homeostasis
gradually
become
hot
topic.
This
review
summarizes
functional
development
progression
therapeutic
improving
dysbiosis,
affecting
metabolism,
immunity.
active
ingredients
used
for
relevant
studies
were
saponins,
triterpenoids,
phenolics,
alkaloids.
In
addition,
to
treat
briefly
discussed.
established
significance
prospects
TCM-based
treatments
provided
necessary
theoretical
support
further
resources
Keywords:
cerebral
injury,
ischemic
stroke,
gut-brain
axis,
microbiota,
traditional
Rapid Communications in Mass Spectrometry,
Год журнала:
2025,
Номер
39(10)
Опубликована: Фев. 10, 2025
ABSTRACT
Gancao
Fuzi
decoction
(GCFZT)
is
a
traditional
Chinese
formula,
which
has
been
commonly
used
in
clinical
practice
to
treat
inflammatory
diseases.
However,
the
active
substance
of
GCFZT
treatment
inflammation
not
fully
clarified.
In
this
study,
we
orthogonal
experiments
design
different
formulations,
resulting
total
16
formulations.
Subsequently,
UPLC‐Q‐TOF‐MS/MS
was
analyze
chemical
composition
and
anti‐inflammatory
activity
differences
these
formulations
were
evaluated
through
an
LPS‐induced
RAW264.7
cell
model.
Combined
with
machine
learning
algorithms
such
as
PLS‐DA
RF,
four
main
substances
screened.
Finally,
network
pharmacology
techniques
investigate
potential
mechanisms
substances,
results
showed
that
mainly
regulates
expression
core
targets
ALOX5,
NFKB1,
TLR4
chlorogenic
acid,
riboflavin,
formononetin,
thereby
affecting
NF
kappa
B
signaling
pathway,
Toll‐like
receptor
Th17
differentiation.
This
study
provides
reference
for
mechanism
scientific
basis
its
application.
Annals of Medicine,
Год журнала:
2023,
Номер
55(2)
Опубликована: Дек. 12, 2023
Purpose
The
aim
of
this
study
is
to
determine
the
effectiveness
and
reliability
adding
traditional
Chinese
medicine
(TCM)
in
clinical
intervention
explore
mechanisms
action
for
chronic
atrophic
gastritis
(CAG)
through
meta-
network
pharmacology
analysis
(NPAs).
