Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 20, 2023
Background
The
retrograde
endocannabinoid
(eCB)
pathway
is
closely
associated
with
the
etiology
of
major
depressive
disorder
(MDD)
at
both
pathophysiological
and
genetic
levels.
This
study
aimed
to
investigate
potential
role
mutations
in
eCB
underlying
mechanisms
Han
Chinese
patients
MDD.
Methods
A
total
96
drug-naïve
first-episode
MDD
62
healthy
controls
(HCs)
were
recruited.
Whole-exome
sequencing
was
performed
identify
gene
mutation
profiles
Results
filtered
focus
on
low-frequency
variants
rare
(minor
allele
frequencies
<0.05)
related
phenotypes.
Enrichment
analyses
for
146
selected
genes
examine
pathways
which
most
significant
enrichment
occurred.
protein–protein
interaction
(PPI)
network
analysis
explore
biological
functions
pathway.
Finally,
based
current
literature,
a
preliminary
conducted
effect
function
this
Our
identified
(15.02%)
depression-related
when
compared
HCs,
37
enriched
signaling
Seven
hub
mitochondrial
function,
including
Complex
I
(NDUFS4,
NDUFV2,
NDUFA2,
NDUFA12,
NDUFB11)
protein
(PARK7)
enzyme
(DLD)
regulation
oxidative
stress.
Conclusion
These
results
indicate
that
represent
etiological
factors
pathogenesis
Biomedicines,
Год журнала:
2022,
Номер
10(12), С. 3000 - 3000
Опубликована: Ноя. 22, 2022
Some
of
the
most
prevalent
neurodegenerative
disorders,
including
Alzheimer’s
and
Parkinson’s
disease,
are
proteinopathies
characterized
by
accumulation
specific
protein
aggregates
in
brain.
Such
misfolded
can
trigger
modulation
innate
adaptive
immune
systems
subsequently
lead
to
chronic
neuroinflammation
that
drives
onset
progression
diseases.
Since
there
is
still
no
effective
disease-modifying
treatment,
new
therapeutic
targets
for
have
been
sought.
The
endocannabinoid
system,
particular
cannabinoid
CB2
receptors,
extensively
studied,
due
their
important
role
neuroinflammation,
especially
microglial
cells.
Several
studies
shown
promising
effects
receptor
activation
on
reducing
aggregation-based
pathology
as
well
attenuating
inflammation
several
dementia-related
symptoms.
In
this
review,
we
discuss
available
data
receptors
potential
benefits
limitations
agonists
these
therapy
proteinopathies.
Veterinary and Animal Science,
Год журнала:
2023,
Номер
19, С. 100289 - 100289
Опубликована: Фев. 7, 2023
Behaviour
is
the
response
of
living
things
to
their
environment
and
external
stimulation,
one
parameters
be
observed
when
assessing
animal
welfare.
Any
alteration
from
conditions
found
in
nature
can
lead
occurrence
some
specific
behaviours,
called
stereotypies
which
are
characterised
as
repetitive,
consistent
patterns
behaviour
usually
defined
having
no
apparent
ultimate
or
proximal
functions.
It
has
been
reported
that
once
stabled
subjected
stressful
activities,
horses
have
more
susceptibility
developing
behavioural
disturbances;
therefore,
disorders
a
strong
indicator
poor
Cannabis
spp.-derived
molecules
studied
under
different
medical
conditions;
therapeutic
potentials
phytocannabinoids
related
effects
delta-9-tetrahydrocannabinol,
cannabidiol
(CBD),
other
compounds.
Cannabidiol
many
activities
within
central
nervous
system,
such
anxiolytic,
antidepressant,
antipsychotic,
anticonvulsant,
anti-inflammatory
activities.
Some
studies
recently
shown
potential
successful
use
veterinary
medicine.
This
clinical
case
report
described
22-year-old
mare
suffering
chronic
crib-biting
wind-sucking,
outcome
four
weeks-therapy
with
CBD.
first
equine
disorders.
CNS Neuroscience & Therapeutics,
Год журнала:
2023,
Номер
29(11), С. 3549 - 3566
Опубликована: Июнь 2, 2023
Abstract
Introduction
Repetitive
transcranial
magnetic
stimulation
(rTMS)
is
a
clinically
useful
therapy
for
depression.
However,
the
effects
of
rTMS
on
metabolism
fatty
acids
(FAs)
and
composition
gut
microbiota
in
depression
are
not
well
established.
Methods
Mice
received
(15
Hz,
1.26
T)
seven
consecutive
days
after
exposure
to
chronic
unpredictable
mild
stress
(CUMS).
The
subsequent
depressive‐like
behaviors,
stool
samples,
as
medium‐
long‐chain
(MLCFAs)
plasma,
prefrontal
cortex
(PFC),
hippocampus
(HPC)
were
evaluated.
Results
CUMS
induced
remarkable
changes
microbiotas
acids,
specifically
community
diversity
PUFAs
brain.
15
Hz
treatment
alleviates
behaviors
partially
normalized
alterations
MLCFAs,
especially
abundance
Cyanobacteria
,
Actinobacteriota
levels
polyunsaturated
(PUFAs)
PFC.
Conclusion
These
findings
revealed
that
modulation
might
partly
contribute
antidepressant
effect
rTMS.
Cell Death Discovery,
Год журнала:
2023,
Номер
9(1)
Опубликована: Дек. 16, 2023
Abstract
Periprosthetic
osteolysis
(PPO)
induced
by
wear
particles
at
the
interface
between
prosthesis
and
bone
is
a
crucial
issue
of
periprosthetic
loss
implant
failure.
After
tear,
granular
material
accumulates
around
joint
prosthesis,
causing
chronic
inflammatory
response,
progressive
osteoclast
activation
eventual
loosening
prosthesis.
Although
many
studies
have
been
conducted
to
address
after
replacement
surgeries,
they
not
fully
addressed
these
issues.
Focusing
on
has
important
theoretical
implications.
Cannabinoid
type
II
receptor
(CB2)
seven-transmembrane
that
predominantly
distributed
in
human
immune
system
revealed
be
highly
expressed
bone-associated
cells.
Previous
shown
modulation
CB2
positive
effect
metabolism.
However,
exact
mechanism
yet
elucidated.
In
our
experiments,
we
found
NOX1-mediated
ROS
accumulation
was
involved
titanium
particle-stimulated
differentiation.
Furthermore,
confirmed
blockade
alleviated
inhibiting
oxidative
stress
pathway.
animal
downregulation
occurrence
particle-induced
cranial
osteoclasts
scavenging
intracellular
ROS.
Collectively,
results
suggest
may
an
attractive
promising
therapeutic
scheme
for
differentiation
preventing
PPO.
Journal of Receptors and Signal Transduction,
Год журнала:
2024,
Номер
unknown, С. 1 - 9
Опубликована: Ноя. 22, 2024
Schizophrenia
is
a
complex
disease
involving
the
dysregulation
of
numerous
brain
circuits
and
patients
exhibit
positive
symptoms
(hallucinations,
delusions),
negative
(anhedonia),
cognitive
impairments.
We
have
shown
that
antipsychotic
efficacy
allosteric
modulators
(PAMs)
both
M
Pharmaceuticals,
Год журнала:
2024,
Номер
17(4), С. 530 - 530
Опубликована: Апрель 19, 2024
Despite
decades
of
rigorous
research
and
numerous
clinical
trials,
Alzheimer’s
disease
(AD)
stands
as
a
notable
healthcare
challenge
this
century,
with
effective
therapeutic
solutions
remaining
elusive.
Recently,
the
endocannabinoid
system
(ECS)
has
emerged
an
essential
target
due
to
its
regulatory
role
in
different
physiological
processes,
such
neuroprotection,
modulation
inflammation,
synaptic
plasticity.
This
aligns
previous
showing
that
cannabinoid
receptor
ligands
have
potential
trigger
functional
structure
neuronal
brain
networks,
potentially
impacting
memory
processing.
Therefore,
our
study
aims
assess
effects
prolonged,
intermittent
exposure
(over
90
days)
JWH-133
(0.2
mg/kg)
EU-GMP
certified
Cannabis
sativa
L.
(Cannabixir®
Medium
Flos,
2.5
on
recognition
memory,
well
their
influence
metabolism
expanded
APP/PS1
mice.
Chronic
therapy
resulted
reduced
anxiety-like
behavior
partially
reversed
cognitive
deficits.
Additionally,
reduction
was
observed
both
number
size
Aβ
plaque
deposits,
along
decreased
cerebral
glucose
metabolism,
decline
expression
mTOR
CB2
receptors.
Furthermore,
revealed
enlarged
astrocytes
enhanced
M1
mAChR
mice
subjected
treatment.
Our
findings
highlight
pivotal
involvement
extended
pathological
aspects
associated
AD,
presenting
preclinical
evidence
support
continued
exploration
assessment
for
AD
