Genetic variations in the retrograde endocannabinoid signaling pathway in Chinese patients with major depressive disorder DOI Creative Commons
Huifang Xu, Tongtong Li, Qiyong Gong

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: April 20, 2023

Background The retrograde endocannabinoid (eCB) pathway is closely associated with the etiology of major depressive disorder (MDD) at both pathophysiological and genetic levels. This study aimed to investigate potential role mutations in eCB underlying mechanisms Han Chinese patients MDD. Methods A total 96 drug-naïve first-episode MDD 62 healthy controls (HCs) were recruited. Whole-exome sequencing was performed identify gene mutation profiles Results filtered focus on low-frequency variants rare (minor allele frequencies <0.05) related phenotypes. Enrichment analyses for 146 selected genes examine pathways which most significant enrichment occurred. protein–protein interaction (PPI) network analysis explore biological functions pathway. Finally, based current literature, a preliminary conducted effect function this Our identified (15.02%) depression-related when compared HCs, 37 enriched signaling Seven hub mitochondrial function, including Complex I (NDUFS4, NDUFV2, NDUFA2, NDUFA12, NDUFB11) protein (PARK7) enzyme (DLD) regulation oxidative stress. Conclusion These results indicate that represent etiological factors pathogenesis

Language: Английский

The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders DOI
Hayatte-Dounia Mir,

Giada Giorgini,

Vincenzo Di Marzo

et al.

Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 154, P. 106295 - 106295

Published: May 18, 2023

Language: Английский

Citations

10
Neuroprotection vs. Neurotoxicity: The Dual Impact of Brain Lipids in Depression DOI Open Access
Yuting Yan, Yan Zhang, Mengting Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2722 - 2722

Published: March 18, 2025

Growing neurochemical evidence highlights cerebral lipid dysregulation as a key factor in the pathophysiology of major depressive disorder (MDD). This review systematically explores dual roles species both normal behavioral regulation and MDD development. By critically examining recent literature, we classify these into two functional categories based on their neuroactivity: (1) neuroprotective lipids (sphingomyelin, cholesterol, cardiolipin, sphingosine, phosphatidic acid, phosphatidylserine), which exert effects by modulating membrane fluidity supporting synaptic vesicle trafficking; (2) neurotoxic (ceramides, phosphatidylinositol, phosphocholine, phosphatidylethanolamine), promote apoptotic signaling cascades disrupt mitochondrial bioenergetics. An unresolved but critical question pertains to maintenance homeostatic equilibrium between opposing classes. balance is essential, given significant impact protein localization function, monoaminergic neurotransmitter metabolism, energy homeostasis, redox neural circuits involved mood regulation. emerging framework positions lipidomics promising avenue for identifying novel therapeutic targets developing biomarker-based diagnostic approaches treatment.

Language: Английский

Citations

0
Decoding the genetic links between substance use disorder and cancer vulnerability DOI

Xin Su,

Xiaoyan Mo,

Jun Kan

et al.

Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0
The use of cannabidiol as a novel treatment for oral stereotypic behaviour (crib-biting) in a horse DOI Creative Commons
Rodrigo Zamith Cunha,

Letícia Locatelli Felisardo,

Giulia Salamanca

et al.

Veterinary and Animal Science, Journal Year: 2023, Volume and Issue: 19, P. 100289 - 100289

Published: Feb. 7, 2023

Behaviour is the response of living things to their environment and external stimulation, one parameters be observed when assessing animal welfare. Any alteration from conditions found in nature can lead occurrence some specific behaviours, called stereotypies which are characterised as repetitive, consistent patterns behaviour usually defined having no apparent ultimate or proximal functions. It has been reported that once stabled subjected stressful activities, horses have more susceptibility developing behavioural disturbances; therefore, disorders a strong indicator poor Cannabis spp.-derived molecules studied under different medical conditions; therapeutic potentials phytocannabinoids related effects delta-9-tetrahydrocannabinol, cannabidiol (CBD), other compounds. Cannabidiol many activities within central nervous system, such anxiolytic, antidepressant, antipsychotic, anticonvulsant, anti-inflammatory activities. Some studies recently shown potential successful use veterinary medicine. This clinical case report described 22-year-old mare suffering chronic crib-biting wind-sucking, outcome four weeks-therapy with CBD. first equine disorders.

Language: Английский

Citations

9
rTMS ameliorates depressive‐like behaviors and regulates the gut microbiome and medium‐ and long‐chain fatty acids in mice exposed to chronic unpredictable mild stress DOI Creative Commons
Cuihong Zhou, Yihuan Chen,

Shan‐Shan Xue

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(11), P. 3549 - 3566

Published: June 2, 2023

Abstract Introduction Repetitive transcranial magnetic stimulation (rTMS) is a clinically useful therapy for depression. However, the effects of rTMS on metabolism fatty acids (FAs) and composition gut microbiota in depression are not well established. Methods Mice received (15 Hz, 1.26 T) seven consecutive days after exposure to chronic unpredictable mild stress (CUMS). The subsequent depressive‐like behaviors, stool samples, as medium‐ long‐chain (MLCFAs) plasma, prefrontal cortex (PFC), hippocampus (HPC) were evaluated. Results CUMS induced remarkable changes microbiotas acids, specifically community diversity PUFAs brain. 15 Hz treatment alleviates behaviors partially normalized alterations MLCFAs, especially abundance Cyanobacteria , Actinobacteriota levels polyunsaturated (PUFAs) PFC. Conclusion These findings revealed that modulation might partly contribute antidepressant effect rTMS.

Language: Английский

Citations

8
CB2 regulates oxidative stress and osteoclastogenesis through NOX1-dependent signaling pathway in titanium particle-induced osteolysis DOI Creative Commons

Huaqiang Tao,

Xueyan Li,

Miao Chu

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Dec. 16, 2023

Abstract Periprosthetic osteolysis (PPO) induced by wear particles at the interface between prosthesis and bone is a crucial issue of periprosthetic loss implant failure. After tear, granular material accumulates around joint prosthesis, causing chronic inflammatory response, progressive osteoclast activation eventual loosening prosthesis. Although many studies have been conducted to address after replacement surgeries, they not fully addressed these issues. Focusing on has important theoretical implications. Cannabinoid type II receptor (CB2) seven-transmembrane that predominantly distributed in human immune system revealed be highly expressed bone-associated cells. Previous shown modulation CB2 positive effect metabolism. However, exact mechanism yet elucidated. In our experiments, we found NOX1-mediated ROS accumulation was involved titanium particle-stimulated differentiation. Furthermore, confirmed blockade alleviated inhibiting oxidative stress pathway. animal downregulation occurrence particle-induced cranial osteoclasts scavenging intracellular ROS. Collectively, results suggest may an attractive promising therapeutic scheme for differentiation preventing PPO.

Language: Английский

Citations

6
Sex-Related and Brain Regional Differences of URB597 Effects on Modulation of MAPK/PI3K Signaling in Chronically Stressed Rats DOI
Milica Janković, Nataša Spasojević, Harisa Ferizović

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(3), P. 1495 - 1506

Published: Sept. 19, 2023

Language: Английский

Citations

5
Editorial: Targeting the endocannabinoidome in neurodegenerative disorders DOI Creative Commons
Hiroki Ishiguro

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 4, 2023

EDITORIAL article Front. Aging Neurosci., 04 January 2023Sec. Cellular and Molecular Mechanisms of Brain-aging Volume 14 - 2022 | https://doi.org/10.3389/fnagi.2022.1116635

Language: Английский

Citations

4
Exploring Cannabinoids with Enhanced Binding Affinity for Targeting the Expanded Endocannabinoid System: A Promising Therapeutic Strategy for Alzheimer’s Disease Treatment DOI Creative Commons
Gabriela Dumitriṭa Stanciu, Daniela Carmen Ababei, Carmen Solcan

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 530 - 530

Published: April 19, 2024

Despite decades of rigorous research and numerous clinical trials, Alzheimer’s disease (AD) stands as a notable healthcare challenge this century, with effective therapeutic solutions remaining elusive. Recently, the endocannabinoid system (ECS) has emerged an essential target due to its regulatory role in different physiological processes, such neuroprotection, modulation inflammation, synaptic plasticity. This aligns previous showing that cannabinoid receptor ligands have potential trigger functional structure neuronal brain networks, potentially impacting memory processing. Therefore, our study aims assess effects prolonged, intermittent exposure (over 90 days) JWH-133 (0.2 mg/kg) EU-GMP certified Cannabis sativa L. (Cannabixir® Medium Flos, 2.5 on recognition memory, well their influence metabolism expanded APP/PS1 mice. Chronic therapy resulted reduced anxiety-like behavior partially reversed cognitive deficits. Additionally, reduction was observed both number size Aβ plaque deposits, along decreased cerebral glucose metabolism, decline expression mTOR CB2 receptors. Furthermore, revealed enlarged astrocytes enhanced M1 mAChR mice subjected treatment. Our findings highlight pivotal involvement extended pathological aspects associated AD, presenting preclinical evidence support continued exploration assessment for AD

Language: Английский

Citations

1
Neuroprotective Effects of Cannabispirenone A against NMDA-Induced Excitotoxicity in Differentiated N2a Cells DOI Creative Commons
Sonia Thapa, Yedukondalu Nalli, Ajeet Singh

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 11

Published: May 31, 2024

The endocannabinoid system is found throughout the central nervous system, and its cannabinoids receptor 1 critical in preventing neurotoxicity caused by N-methyl-D-aspartate activation (NMDARs). activity of NMDARs places demands on endogenous to regulate their calcium currents. Endocannabinoids keep NMDAR within safe limits, protecting neural cells from excitotoxicity. Cannabinoids are remembered deliver this outcome repressing presynaptic glutamate discharge or obstructing postsynaptic NMDAR-managed flagging pathways. must exert a negative influence proportional strength signaling for such control be effective. goal paper draw attention towards neuroprotective mechanism constituents Cannabis sativa against NMDA-induced excitotoxic result. Phytochemical investigation cannabis flowers led isolation nine secondary metabolites. A spiro-compound, Cannabispirenone A, which treatment prior NMDA exposure significantly increases cell survival while decreasing ROS production, lipid peroxidation, intracellular calcium. Our findings showed that compound neuroprotection insult, has antioxidative properties, increased cannabinoid expression, may involved pathway neuroprotection.

Language: Английский

Citations

1