Cells,
Год журнала:
2023,
Номер
12(12), С. 1667 - 1667
Опубликована: Июнь 19, 2023
Pathological
cardiac
hypertrophy
is
one
of
the
notable
causes
heart
failure.
Circular
RNAs
(circRNAs)
have
been
studied
in
association
with
hypertrophy;
however,
mechanisms
by
which
circRNAs
regulate
remain
unclear.
In
this
study,
we
identified
a
new
circRNA,
named
circCacna1c,
hypertrophy.
Adult
male
C57BL/6
mice
and
H9c2
cells
were
treated
isoprenaline
hydrochloride
(ISO)
to
establish
model.
We
found
that
circCacna1c
was
upregulated
ISO-induced
hypertrophic
tissue
cells.
Western
blot
quantitative
real-time
polymerase
chain
reaction
showed
silencing
inhibited
gene
expression
Mechanistically,
competitively
bound
miR-29b-2-5p
dual-luciferase
reporter
assay,
downregulated
MiR-29b-2-5p
nuclear
factor
activated
T
cells,
cytoplasmic,
calcineurin-dependent
1
(NFATc1)
control
expression.
After
increased,
reduced
inhibiting
NFATc1
Together,
these
experiments
indicate
promotes
pathological
through
miR-29b-2-5p/NFATc1
axis.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(9), С. 8181 - 8181
Опубликована: Май 3, 2023
Mitochondria
are
organelles
present
in
almost
all
eukaryotic
cells,
where
they
represent
the
main
site
of
energy
production.
involved
several
important
cell
processes,
such
as
calcium
homeostasis,
OXPHOS,
autophagy,
and
apoptosis.
Moreover,
play
a
pivotal
role
also
inflammation
through
inter-organelle
inter-cellular
communications,
mediated
by
release
mitochondrial
damage-associated
molecular
patterns
(mtDAMPs).
It
is
currently
well-documented
that
addition
to
traditional
endocrine
paracrine
communication,
cells
converse
via
extracellular
vesicles
(EVs).
These
small
membrane-bound
particles
released
from
milieu
under
physio-pathological
conditions.
Importantly,
EVs
have
gained
much
attention
for
their
crucial
translating
inflammatory
signals
into
recipient
cells.
cargo
includes
plasma
membrane
endosomal
proteins,
but
contain
material
other
cellular
compartments,
including
mitochondria.
Studies
shown
may
transport
portions,
and/or
mtDAMPs
modulate
metabolic
responses
Overall,
relationship
between
mitochondria
an
active
area
research,
although
further
studies
needed
fully
understand
mechanisms
how
be
targeted
therapeutic
purposes.
Here,
we
reported
discussed
latest
focused
on
this
fascinating
recent
discussing
tricky
connection
inflammatory-related
diseases.
Abstract
Obesity
is
a
complex,
chronic,
and
recurrent
disease
marked
by
abnormal
or
excessive
fat
accumulation
that
poses
significant
health
risks.
The
distribution
of
body
fat,
especially
ectopic
deposition,
plays
crucial
role
in
the
development
chronic
metabolic
diseases.
Under
normal
conditions,
fatty
acids
are
primarily
stored
subcutaneous
adipose
tissue;
however,
intake
can
lead
to
visceral
tissue
sites,
including
pancreas,
heart,
muscle.
This
redistribution
associated
with
disruptions
energy
metabolism,
inflammation,
insulin
resistance,
impairing
organ
function
raising
risk
cardiovascular
disease,
diabetes,
liver.
review
explores
roles
resistance
related
diseases
such
as
type
2
diabetes
dysfunction‐associated
steatotic
liver
disease.
Specifically,
we
examine
structure
characteristics
different
types,
their
associations
underlying
pathogenic
mechanisms.
Future
strategies
for
managing
obesity‐related
may
include
lifestyle
modifications,
surgical
interventions,
emerging
medications
target
lipid
metabolism
regulation,
aiming
improve
patient
outcomes.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
160, С. 114413 - 114413
Опубликована: Фев. 17, 2023
Arrhythmia
is
characterized
by
abnormal
heartbeat
rhythms
and
frequencies
caused
heart
pacing
conduction
dysfunction.
the
leading
cause
of
death
in
patients
with
cardiovascular
disease,
high
morbidity
mortality
rates,
posing
a
serious
risk
to
human
health.
Natural
drugs
their
active
ingredients,
such
as
matrine(MAT),
tetrandrine(TET),
dehydroevodiamine,
tanshinone
IIA,
ginsenosides,
have
been
widely
used
for
treatment
atrial
fibrillation,
ventricular
ectopic
beats,
sick
sinus
syndrome,
other
arrhythmia-like
diseases
owing
unique
advantages.
This
review
summarizes
mechanism
action
natural
ingredients
arrhythmia
via
regulation
Ca2+,
alkaloids,
quinones,
saponins,
terpenoids,
flavonoids,
polyphenols,
lignan
compounds,
provide
ideas
innovative
development
potential
antiarrhythmic
efficacy.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3414 - 3414
Опубликована: Фев. 8, 2023
The
most
common
alterations
affecting
mitochondria,
and
associated
with
cardiac
pathological
conditions,
implicate
a
long
list
of
defects.
They
include
impairments
the
mitochondrial
electron
transport
chain
activity,
which
is
crucial
element
for
energy
formation,
that
determines
depletion
ATP
generation
supply
to
metabolic
switches,
enhanced
ROS
generation,
inflammation,
as
well
dysregulation
intracellular
calcium
homeostasis.
All
these
signatures
significantly
concur
in
impairment
electrical
characteristics,
loss
myocyte
contractility
cardiomyocyte
damage
found
diseases.
Mitochondrial
dynamics,
one
quality
control
mechanisms
at
basis
fitness,
also
result
being
dysregulated,
but
use
this
knowledge
translational
therapeutic
purposes
still
its
infancy.
In
review
we
tried
understand
why
is,
by
summarizing
methods,
current
opinions
molecular
details
underlying
dynamics
Bioinorganic Chemistry and Applications,
Год журнала:
2022,
Номер
2022(1)
Опубликована: Янв. 1, 2022
Solid
tumors
have
a
unique
tumor
microenvironment
(TME),
which
includes
hypoxia,
low
acidity,
and
high
hydrogen
peroxide
glutathione
(GSH)
levels,
among
others.
These
factors,
offer
favourable
microenvironments
nourishment
for
development
spread,
also
serve
as
gateway
specific
successful
cancer
therapies.
A
good
example
is
metal
structures
been
synthesized
utilized
to
enhance
oxygen
supply
they
shown
great
promise
in
the
alleviation
of
hypoxia.
In
hypoxic
environment,
certain
oxygen‐dependent
treatments
such
photodynamic
therapy
radiotherapy
fail
respond
therefore
modulating
has
found
antitumor
impact
drugs.
Under
acidic
environments,
produced
by
reaction
peroxides
with
water
not
only
induces
oxidative
stress
but
produces
additional
oxygen.
This
achieved
since
acts
reactive
substrate
molecules
catalyse
enzymes,
alleviating
hypoxia
observed
microenvironment.
Metal
ions
released
process
can
distinct
bioactivity
their
own
right.
used
anticancer
are
rapidly
evolving
field,
there
evidence
that
option
regulating
therapy.
this
regard,
synthesis
mechanisms
behind
application
specifically
target
highlighted
review.
Various
characteristics
TME
angiogenesis,
inflammation,
acidity
ion
homeostasis
addressed
together
forms
synergistic
combination
treatments.
ACS Nano,
Год журнала:
2024,
Номер
18(45), С. 31569 - 31585
Опубликована: Ноя. 1, 2024
Exposure
to
micro-
and
nanoplastics
(MNPs)
has
been
implicated
in
potential
cardiotoxicity.
However,
vitro
models
based
on
cardiomyocyte
cell
lines
lack
crucial
cardiac
characteristics,
while
interspecies
differences
animal
compromise
the
reliability
of
conclusions.
In
addition,
current
research
predominantly
focused
single-time
point
exposures
MNPs,
neglecting
comparative
analyses
injury
across
early
late
stages.
Moreover,
there
remains
a
large
gap
understanding
susceptibility
MNPs
under
pathological
conditions.
To
address
these
limitations,
this
study
integrated
organoids
(COs)
organ-on-a-chip
(OoC)
technology
develop
organoid-on-a-chip
(COoC),
which
was
validated
for
cardiotoxicity
evaluation
through
multiple
dimensions.
Based
COoC,
we
conducted
dynamic
observation
damage
caused
by
short-
long-term
exposure
polystyrene
(PS-NPs).
Oxidative
stress,
inflammation,
disruption
calcium
ion
homeostasis,
mitochondrial
dysfunction
were
confirmed
as
mechanisms
PS-NP-induced
events
stages,
fibrosis
emerged
prominent
feature
Notably,
low-dose
exacerbated
myocardial
infarction
symptoms
states,
despite
no
significant
shown
healthy
models.
conclusion,
findings
further
deepened
our
cardiotoxic
effects
introduced
promising
platform
assessing
International Journal of Pharmaceutics,
Год журнала:
2022,
Номер
629, С. 122356 - 122356
Опубликована: Ноя. 1, 2022
Extracellular
vesicles
(EVs)
are
nanosized
particles
with
attractive
therapeutic
potential
for
cardiac
repair.
However,
low
retention
and
stability
after
systemic
administration
limit
their
clinical
translation.
As
an
alternative,
the
combination
of
EVs
biomaterial-based
hydrogels
(HGs)
is
being
investigated
to
increase
exposure
in
myocardium
achieve
optimal
effect.
In
this
study,
we
developed
characterized
a
novel
injectable
in-situ
forming
HG
based
on
alginate
collagen
as
delivery
vehicle
EVs.
Different
concentrations
crosslinked
calcium
gluconate
were
tested.
Based
injectability
studies,
1%
alginate,
0.5
mg/mL
0.25%
was
selected
idoneous
using
catheter-based
systems.
Rheological
examination
revealed
that
possessed
internal
gel
structure,
weak
mechanical
properties
viscosity,
facilitating
easy
administration.
addition,
successfully
incorporated
homogeneously
distributed
HG.
After
rat
model
myocardial
infarction,
showed
long-term
heart
allowed
sustained
release
at
least
7
days.
Thus,
HGs
represents
promising
strategy
Besides
delivery,
could
represent
useful
platform
multiple
agents.
