Advancing herbal medicine: enhancing product quality and safety through robust quality control practices

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Сен. 25, 2023

This manuscript provides an in-depth review of the significance quality control in herbal medication products, focusing on its role maintaining efficiency and safety. With a historical foundation traditional medicine systems, remedies have gained widespread popularity as natural alternatives to conventional treatments. However, increasing demand for these products necessitates stringent measures ensure consistency comprehensive explores importance methods monitoring various aspects product development, manufacturing, distribution. Emphasizing need standardized processes, delves into detection prevention contaminants, authentication ingredients, adherence regulatory standards. Additionally, it highlights integration knowledge modern scientific approaches achieving optimal outcomes. By emphasizing medicine, this contributes promoting consumer trust, safeguarding public health, fostering responsible use products.

Язык: Английский

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Yam Glycoprotein Promotes White Adipose Tissue Browning, Enhances Metabolism, and Boosts Exercise Tolerance in Mice: A Novel Strategy for Metabolic Disease Prevention

Food Bioscience, Год журнала: 2025, Номер 64, С. 105818 - 105818

Опубликована: Янв. 5, 2025

Язык: Английский

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Role of herbal medicine and gut microbiota in the prevention and treatment of obesity

Journal of Ethnopharmacology, Год журнала: 2023, Номер 305, С. 116127 - 116127

Опубликована: Янв. 2, 2023

Язык: Английский

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Flavonoid extracts of Citrus aurantium L. var. amara Engl. Promote browning of white adipose tissue in high-fat diet-induced mice

Journal of Ethnopharmacology, Год журнала: 2024, Номер 324, С. 117749 - 117749

Опубликована: Янв. 21, 2024

Язык: Английский

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Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway

Virology Journal, Год журнала: 2023, Номер 20(1)

Опубликована: Июль 19, 2023

Abstract African swine fever (ASF) is an acute infectious haemorrhagic of pigs caused by virus (ASFV). Aloe-emodin (Ae) active ingredient Chinese herbs with antiviral, anticancer, and anti-inflammatory effects. We investigated the antiviral activity mechanism action Ae against ASFV using Real-time quantitative PCR (qPCR), western blotting, indirect immunofluorescence assays. significantly inhibited replication. Furthermore, transcriptomic analysis revealed that infection activated NF-κB signaling pathway in early stage apoptosis late stage. downregulated expression levels MyD88, phosphor-NF-κB p65, pIκB proteins as well mRNA IL-1β IL-8 porcine alveolar macrophages (PAMs) infected ASFV, thereby inhibiting activation induced ASFV. Flow cytometry blot increased percentage ASFV-induced apoptotic cells. Additionally, promoted upregulating cleaved-caspase3 Bax downregulating Bcl-2 proteins. This suggests promotes pathway, resulting inhibition These findings have further improved therapeutic reserves for prevention treatment ASF.

Язык: Английский

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Role of carotenoids in adipose tissue through the AMPK-mediated pathway

Food & Function, Год журнала: 2023, Номер 14(8), С. 3454 - 3462

Опубликована: Янв. 1, 2023

Carotenoids are lipophilic pigments with anti-inflammatory properties and effects on cell differentiation. could ameliorate complications induced by a high-fat diet affecting energy metabolism adipogenesis via AMPK pathway.

Язык: Английский

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Hydroxy-α-sanshool from the fruits of Zanthoxylum bungeanum Maxim. promotes browning of white fat by activating TRPV1 to induce PPAR-γ deacetylation

Phytomedicine, Год журнала: 2023, Номер 121, С. 155113 - 155113

Опубликована: Сен. 21, 2023

Язык: Английский

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Liraglutide induced browning of visceral white adipose through regulation of miRNAs in high-fat-diet-induced obese mice

Endocrine, Год журнала: 2024, Номер 85(1), С. 222 - 232

Опубликована: Фев. 20, 2024

Язык: Английский

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Quercetin activates energy expenditure to combat metabolic syndrome through modulating gut microbiota-bile acids crosstalk in mice

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 20, 2024

Abdominal obesity-related metabolic syndrome (MetS) has emerged as a significant global public health issue that affects human health. Flavonoids, such quercetin, have been reported to exert obvious anti-obesity and lipid-lowering effects in both humans animal models. However, the precise underlying mechanism remains elusive. In this study, we investigated potential roles of gut microbiota-bile acids (BAs) interactions quercetin-induced benefits. Oral administration quercetin significantly enhanced energy metabolism through activating thermogenesis brown adipose tissues (BAT) browning white (WAT), thus mitigating dysfunctions an abdominal MetS mouse model. Further mechanistic studies demonstrated treatment substantially promoted generation non-12α-hydroxylated BAs (non-12OH BAs), particularly ursodeoxycholic acid (UDCA) lithocholic (LCA), serum via regulating overall structure microbiota enriching Lactobacillus. High level non-12OH bind Takeda G protein-coupled receptor 5 (TGR5) on adipocytes stimulate thermogenesis. Remarkably, fecal transplantation (FMT) from quercetin-treated mice replicated expenditure, which suggested reshape concomitant regulation were responsible for benefits Our findings not only highlighted critical role microbiota-BAs crosstalk mediating but also enriched pharmacological mechanisms ameliorating MetS-related diseases.

Язык: Английский

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Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling

Journal of Integrative Medicine, Год журнала: 2024, Номер 22(1), С. 83 - 92

Опубликована: Янв. 1, 2024

Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs; however, concerns regarding complexities side effects persist, driving research for more effective, low-risk strategies. The promotion of white adipose tissue (WAT) browning has emerged as promising approach. Moreover, alisol B 23-acetate (AB23A) demonstrated efficacy in addressing metabolic disorders, suggesting its potential therapeutic agent obesity management. Therefore, this study, we aimed to investigate the AB23A mitigating by regulating phenotypes lipid distribution mice fed high-fat diet (HFD). An mouse model was established administration an HFD. Glucose insulin metabolism were assessed via glucose tolerance tests. Adipocyte size determined using hematoxylin eosin staining. expression markers WAT evaluated Western blotting quantitative real-time polymerase chain reaction. Metabolic cage monitoring involved assessment various parameters, including food water intake, energy metabolism, respiratory exchange rates, physical activity. oil red O staining used evaluate intracellular accumulation. A bioinformatic analysis tool identifying molecular mechanisms traditional Chinese medicine examine targets associated signaling pathways. significantly reduced weight obese mice, decreased mass inguinal WAT, epididymal perirenal tissue, improved adipocyte size. treatment promoted enhanced overall had no discernible effect on consumption, or In 3T3-L1 cells, inhibited accumulation, both rapamycin mammalian target rapamycin-sterol regulatory element-binding protein-1 (mTOR-SREBP1) pathway. Furthermore, 3-isobutyl-1-methylxanthine, dexamethasone insulin, at concentrations 0.25 mmol/L, μmol/L 1 μg/mL, respectively, induced activation mTOR-SREBP1 pathway, which further strengthened mTOR activator MHY1485. Notably, MHY1485 reversed beneficial cells. inhibiting offering strategy prevent obesity.

Язык: Английский

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