Dietary Supplements for Weight Loss and Drug Interactions DOI Creative Commons
Francisco Rivas García, Jorge Sierra, Maria Isabel Valverde‐Merino

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1658 - 1658

Published: Dec. 9, 2024

Food supplements are used for a variety of purposes, one which is weight reduction. As excess long-term condition, some expected to be long periods time. The use these dietary makes it highly likely that they will combined with medications, increasing the risk food supplement–drug interactions, not always known or disclosed, and can lead serious health problems, as has been observed. This article discusses compounds reduction (green tea extract, Garcinia cambogia, chitosan, quercetin resveratrol) interactions may cause drugs such as: dextromethorphan, buspirone, diclofenac, irinotecan, 5-fluorouracil, cytochrome P450 inducers inhibitors, statins, orlistat, warfarina, acenocoumarol, fluoxetine, valproate, quetiapine, carbamazepine. information useful healthcare professionals detect intervene on ensure optimization therapy patient safety.

Language: Английский

Advancing herbal medicine: enhancing product quality and safety through robust quality control practices DOI Creative Commons
Hongting Wang, Ying Chen, Lei Wang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 25, 2023

This manuscript provides an in-depth review of the significance quality control in herbal medication products, focusing on its role maintaining efficiency and safety. With a historical foundation traditional medicine systems, remedies have gained widespread popularity as natural alternatives to conventional treatments. However, increasing demand for these products necessitates stringent measures ensure consistency comprehensive explores importance methods monitoring various aspects product development, manufacturing, distribution. Emphasizing need standardized processes, delves into detection prevention contaminants, authentication ingredients, adherence regulatory standards. Additionally, it highlights integration knowledge modern scientific approaches achieving optimal outcomes. By emphasizing medicine, this contributes promoting consumer trust, safeguarding public health, fostering responsible use products.

Language: Английский

Citations

108
Yam Glycoprotein Promotes White Adipose Tissue Browning, Enhances Metabolism, and Boosts Exercise Tolerance in Mice: A Novel Strategy for Metabolic Disease Prevention DOI
Weiye Li, Yifeng Rang,

Jian Shi

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: 64, P. 105818 - 105818

Published: Jan. 5, 2025

Language: Английский

Citations

1
Role of herbal medicine and gut microbiota in the prevention and treatment of obesity DOI
Qiao Zhang,

Yaya Bai,

Wenxiao Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 305, P. 116127 - 116127

Published: Jan. 2, 2023

Language: Английский

Citations

22
Flavonoid extracts of Citrus aurantium L. var. amara Engl. Promote browning of white adipose tissue in high-fat diet-induced mice DOI

Song‐Xia Lin,

Chun Yang,

R H Jiang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 324, P. 117749 - 117749

Published: Jan. 21, 2024

Language: Английский

Citations

7
Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway DOI Creative Commons

Yizhuo Luo,

Yunlong Yang, Wenru Wang

et al.

Virology Journal, Journal Year: 2023, Volume and Issue: 20(1)

Published: July 19, 2023

Abstract African swine fever (ASF) is an acute infectious haemorrhagic of pigs caused by virus (ASFV). Aloe-emodin (Ae) active ingredient Chinese herbs with antiviral, anticancer, and anti-inflammatory effects. We investigated the antiviral activity mechanism action Ae against ASFV using Real-time quantitative PCR (qPCR), western blotting, indirect immunofluorescence assays. significantly inhibited replication. Furthermore, transcriptomic analysis revealed that infection activated NF-κB signaling pathway in early stage apoptosis late stage. downregulated expression levels MyD88, phosphor-NF-κB p65, pIκB proteins as well mRNA IL-1β IL-8 porcine alveolar macrophages (PAMs) infected ASFV, thereby inhibiting activation induced ASFV. Flow cytometry blot increased percentage ASFV-induced apoptotic cells. Additionally, promoted upregulating cleaved-caspase3 Bax downregulating Bcl-2 proteins. This suggests promotes pathway, resulting inhibition These findings have further improved therapeutic reserves for prevention treatment ASF.

Language: Английский

Citations

15
Role of carotenoids in adipose tissue through the AMPK-mediated pathway DOI
Yasmin Alaby Martins Ferreira, Giovana Jamar, Débora Estadella

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(8), P. 3454 - 3462

Published: Jan. 1, 2023

Carotenoids are lipophilic pigments with anti-inflammatory properties and effects on cell differentiation. could ameliorate complications induced by a high-fat diet affecting energy metabolism adipogenesis via AMPK pathway.

Language: Английский

Citations

12
Hydroxy-α-sanshool from the fruits of Zanthoxylum bungeanum Maxim. promotes browning of white fat by activating TRPV1 to induce PPAR-γ deacetylation DOI
Qing Zhang,

Cheng-Xun He,

Ling‐Yu Wang

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 121, P. 155113 - 155113

Published: Sept. 21, 2023

Language: Английский

Citations

11
Liraglutide induced browning of visceral white adipose through regulation of miRNAs in high-fat-diet-induced obese mice DOI
Li Zhao, Wenxin Li, Panpan Zhang

et al.

Endocrine, Journal Year: 2024, Volume and Issue: 85(1), P. 222 - 232

Published: Feb. 20, 2024

Language: Английский

Citations

4
Quercetin activates energy expenditure to combat metabolic syndrome through modulating gut microbiota-bile acids crosstalk in mice DOI Creative Commons
Xiaoqiang Zhu,

Xiaojuan Dai,

Lijun Zhao

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 20, 2024

Abdominal obesity-related metabolic syndrome (MetS) has emerged as a significant global public health issue that affects human health. Flavonoids, such quercetin, have been reported to exert obvious anti-obesity and lipid-lowering effects in both humans animal models. However, the precise underlying mechanism remains elusive. In this study, we investigated potential roles of gut microbiota-bile acids (BAs) interactions quercetin-induced benefits. Oral administration quercetin significantly enhanced energy metabolism through activating thermogenesis brown adipose tissues (BAT) browning white (WAT), thus mitigating dysfunctions an abdominal MetS mouse model. Further mechanistic studies demonstrated treatment substantially promoted generation non-12α-hydroxylated BAs (non-12OH BAs), particularly ursodeoxycholic acid (UDCA) lithocholic (LCA), serum via regulating overall structure microbiota enriching Lactobacillus. High level non-12OH bind Takeda G protein-coupled receptor 5 (TGR5) on adipocytes stimulate thermogenesis. Remarkably, fecal transplantation (FMT) from quercetin-treated mice replicated expenditure, which suggested reshape concomitant regulation were responsible for benefits Our findings not only highlighted critical role microbiota-BAs crosstalk mediating but also enriched pharmacological mechanisms ameliorating MetS-related diseases.

Language: Английский

Citations

4
Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling DOI Creative Commons
Lulu Han, Xin Zhang, Hui Zhang

et al.

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(1), P. 83 - 92

Published: Jan. 1, 2024

Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs; however, concerns regarding complexities side effects persist, driving research for more effective, low-risk strategies. The promotion of white adipose tissue (WAT) browning has emerged as promising approach. Moreover, alisol B 23-acetate (AB23A) demonstrated efficacy in addressing metabolic disorders, suggesting its potential therapeutic agent obesity management. Therefore, this study, we aimed to investigate the AB23A mitigating by regulating phenotypes lipid distribution mice fed high-fat diet (HFD). An mouse model was established administration an HFD. Glucose insulin metabolism were assessed via glucose tolerance tests. Adipocyte size determined using hematoxylin eosin staining. expression markers WAT evaluated Western blotting quantitative real-time polymerase chain reaction. Metabolic cage monitoring involved assessment various parameters, including food water intake, energy metabolism, respiratory exchange rates, physical activity. oil red O staining used evaluate intracellular accumulation. A bioinformatic analysis tool identifying molecular mechanisms traditional Chinese medicine examine targets associated signaling pathways. significantly reduced weight obese mice, decreased mass inguinal WAT, epididymal perirenal tissue, improved adipocyte size. treatment promoted enhanced overall had no discernible effect on consumption, or In 3T3-L1 cells, inhibited accumulation, both rapamycin mammalian target rapamycin-sterol regulatory element-binding protein-1 (mTOR-SREBP1) pathway. Furthermore, 3-isobutyl-1-methylxanthine, dexamethasone insulin, at concentrations 0.25 mmol/L, μmol/L 1 μg/mL, respectively, induced activation mTOR-SREBP1 pathway, which further strengthened mTOR activator MHY1485. Notably, MHY1485 reversed beneficial cells. inhibiting offering strategy prevent obesity.

Language: Английский

Citations

3