Biochemical Pharmacology, Год журнала: 2025, Номер 233, С. 116752 - 116752
Опубликована: Янв. 10, 2025
Язык: Английский
Molecules, Год журнала: 2023, Номер 28(20), С. 7039 - 7039
Опубликована: Окт. 12, 2023
Large bone defects due to trauma, infections, and tumors are difficult heal spontaneously by the body’s repair mechanisms have become a major hindrance people’s daily lives economic development. However, autologous allogeneic grafts, with their lack of donors, more invasive surgery, immune rejection, potential viral transmission, hinder development repair. Hydrogel tissue bioengineered scaffolds gained widespread attention in field good biocompatibility three-dimensional network structure that facilitates cell adhesion proliferation. In addition, loading natural products nanoparticles incorporating them into hydrogel is one most effective strategies promote bioactivity limitations products. Therefore, this paper presents brief review application hydrogels different gel-forming properties, matrices, nanoparticle-loaded loaded incorporated for defect recent years.
Язык: Английский
Процитировано
22
Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 4661 - 4677
Опубликована: Окт. 1, 2023
Abstract: Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. involved variety of physiological pathological processes. Since its discovery, has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress prospects, summarize regulatory mechanisms ferroptosis, discuss role pathogenesis diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), well therapeutic potential. Keywords: death, iron accumulation, peroxidation, diseases
Язык: Английский
Процитировано
20
International Immunopharmacology, Год журнала: 2023, Номер 117, С. 109991 - 109991
Опубликована: Март 9, 2023
Язык: Английский
Процитировано
18
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2023, Номер 1870(6), С. 119480 - 119480
Опубликована: Апрель 30, 2023
Язык: Английский
Процитировано
18
Advanced Science, Год журнала: 2023, Номер 10(22)
Опубликована: Май 25, 2023
Abstract The local application of drug‐loaded bioactive scaffold materials is one the important directions to solve clinical problem osteoporotic (OP) bone defects. This study retains advantages drug loading and mechanical properties natural 3D scaffolds. scaffolds are functionally modified through chemical self‐assembly approaches with polydopamine (PDA) nanoparticles parathyroid hormone‐related peptide‐1 (PTHrP‐1) for efficient loading. investigates effects novel on ossification, osteoclastogenesis, macrophage polarization. work elucidates in regulating osteoclastic activity new formation vitro. Further studies establishment repair OP defects small animals conducted, potential porous promote initially verified. preparation safe economical anti‐OP material provides a theoretical basis translational applications.
Язык: Английский
Процитировано
17
Chemical Engineering Journal, Год журнала: 2023, Номер 472, С. 144978 - 144978
Опубликована: Июль 22, 2023
Язык: Английский
Процитировано
16
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Апрель 2, 2024
Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung (NSCLC) being predominant type. The roles autophagy and apoptosis in NSCLC present a dual intricate nature. Additionally, interconnect through diverse crosstalk molecules. Owing to their multitargeting nature, safety, efficacy, natural products have emerged as principal sources for therapeutic candidates. This review begins an exploration mechanisms apoptosis, proceeds examine molecules between these processes, outlines implications interactions NSCLC. Finally, paper reviews that been intensively studied against targeting summarizes detail four most retrieved representative drugs. clarifies good effects by aims promote greater consideration researchers candidates anti-NSCLC drug discovery.
Язык: Английский
Процитировано
7
Journal of Natural Products, Год журнала: 2024, Номер 87(1), С. 160 - 165
Опубликована: Янв. 9, 2024
One novel rearranged pimarane diterpenoid, pestanoid A (1), and two reported molecules, nodulisporenones (2) B (3), were discovered from Pestalotiopsis sp. NBUF145 fungus associated with a 62 m deep mesophotic ("twilight") zone Chalinidae sponge. The structures of 1–3 identified by spectrometry, spectroscopy, quantum-chemical calculations, X-ray crystallography. Compounds 1 2 inhibited bone marrow monocyte osteoclastogenesis in vitro the IC50 values 4.2 ± 0.2 μM 3.0 0.4 μM, respectively, without observed cytotoxicity. Both suppressed receptor activator NF-kB ligand-induced MAPK NF-κB signaling inhibiting phosphorylation ERK1/2-JNK1/2-p38 MAPKs nuclear translocation.
Язык: Английский
Процитировано
6
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Фев. 23, 2023
Inflammatory bowel disease (IBD) can progress into colitis-associated colorectal cancer (CAC) through the inflammation-cancer sequence. Although mechanism of carcinogenesis in IBD has not been fully elucidated, existing research indicates that CAC may represent a fundamentally different pathogenesis pattern cancer. At present, there is no proven safe and effective medication to prevent In recent years, Chinese medicine extracts monomers have subject numerous articles about prevention treatment CAC, but their clinical application still relatively limited. Traditional Medicine (TCM) formulas are widely applied practice. TCM demonstrated great potential although lack review. Our work aimed summarize effects mechanisms for point out issues limitations current research, provide recommendations advancement future. We discovered regulated many malignant biological processes, such as inflammation-mediated oxidative stress, apoptosis, tumor microenvironment, intestinal microecology imbalance review published databases
Язык: Английский
Процитировано
13
Journal of Orthopaedic Surgery and Research, Год журнала: 2024, Номер 19(1)
Опубликована: Янв. 6, 2024
Abstract Background Osteoporosis (OP) poses a significant clinical challenge with escalating morbidity. This study explores Circ_HECW2 expression in OP patients and its regulatory role lipopolysaccharide (LPS)-induced osteoblast apoptosis. Methods patient serum healthy controls was quantified using RT-qPCR. Diagnostic value of for assessed via ROC curve. Pearson’s correlation model examined associations between indicators. Human osteoblasts HFOB1.19, treated LPS, were analyzed Circ_HECW2, pre-miR-1224, miR-1224-5p, PDK2 mRNA levels. TUNEL assay determined cell apoptosis Western blot cleaved-caspase-3 protein RNase R resistance actinomycin D confirmed Circ_HECW2’s cyclic structure. RNA pull-down dual-luciferase reporter verified binding relationships miR-1224 miR-1224-5p PDK2. Results exhibited elevated diagnostic significance negative lumbar T-score. LPS co-culture increased HFOB1.19 cells, significantly elevating index cleaved-caspase-3. downregulation inhibited apoptosis, reduced pre-miR-1224 expression, mature miR-1224-5p. bound to inhibiting reversed the effect on targeted transcription. Conclusion highly expressed OP, holds reflects disease severity. reduces by upregulating PDK2, facilitating LPS-induced Graphic
Язык: Английский
Процитировано
5