Tobacco smoking and sarcoidosis revisited — evidence, mechanisms, and clinical implications: a narrative review

Current Medical Research and Opinion, Год журнала: 2025, Номер unknown, С. 1 - 26

Опубликована: Апрель 21, 2025

Sarcoidosis is a multisystem inflammatory disease with unclear etiology, influenced by genetic predisposition and environmental exposures. Smoking has been widely studied for its potential role in sarcoidosis, conflicting evidence regarding impact on risk, severity, treatment response. While some epidemiologic studies suggest that smoking associated lower risk of others highlight variations based geography, ethnicity, history. Assessing the effects particularly challenging because complex composition tobacco smoke, which contains thousands chemicals diverse biologic effects. Nicotine, major component tobacco, demonstrated both pro- anti-inflammatory properties, further complicating sarcoidosis. This narrative review explored relationship between sarcoidosis examining smoking's immune modulation, presentation prognosis, response to immunosuppressive therapy. By summarizing current evidence, this paper aimed clarify nicotine identify key areas future research, understanding mechanisms underlying smoking-related modulation outcomes.

Язык: Английский

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The neuronal-like behaviour of macrophages

Trends in Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Auxiliary protein and chaperone regulation of neuronal nicotinic receptor subtype expression and function

Pharmacological Research, Год журнала: 2024, Номер 200, С. 107067 - 107067

Опубликована: Янв. 11, 2024

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of pentameric, ligand-gated ion channels that located on the surface neurons and non-neuronal cells have multiple physiological pathophysiological functions. In order to reach cell surface, many nAChR subtypes require help chaperone and/or auxiliary/accessory proteins for their assembly, trafficking, pharmacological modulation, normal functioning in vivo. The use powerful genome-wide cDNA screening has led identification characterisation molecules mechanisms participate assembly trafficking receptor subtypes, including auxiliary or accessory proteins. aim this review is describe latest findings concerning chaperones chaperones, how some them control biogenesis regulate channel activation pharmacology. Some subtype selective, various not only modulate nAChRs but also target other signalling pathways. We discuss changes may be involved dysfunctions.

Язык: Английский

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Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen–gut–brain axis

Journal of Affective Disorders, Год журнала: 2024, Номер 362, С. 114 - 125

Опубликована: Июнь 27, 2024

Язык: Английский

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Macrophage α7nAChR alleviates the inflammation of neonatal necrotizing enterocolitis through mTOR/NLRP3/IL-1β pathway

International Immunopharmacology, Год журнала: 2024, Номер 139, С. 112590 - 112590

Опубликована: Июль 13, 2024

Neonatal necrotizing enterocolitis (NEC) is one of the most prevalent and severe intestinal emergencies in newborns. The inflammatory activation macrophages associated with injury NEC. neuroimmune regulation mediated by α7 nicotinic acetylcholine receptor (α7nAChR) plays an important role regulating macrophage inflammation progression, but NEC remains unclear. This study aims to explore effect α7nAChR on

Язык: Английский

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Special Issue "The multifaceted activities of nervous and non-nervous neuronal nicotinic acetylcholine receptors in physiology and pathology"

Pharmacological Research, Год журнала: 2024, Номер 205, С. 107239 - 107239

Опубликована: Май 25, 2024

Язык: Английский

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Vagus nerve electrical stimulation in the recovery of upper limb motor functional impairment after ischemic stroke

Cognitive Neurodynamics, Год журнала: 2024, Номер 18(5), С. 3107 - 3124

Опубликована: Июль 1, 2024

Язык: Английский

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Pterostilbene Ameliorates Cognitive Impairment in Polycystic Ovary Syndrome Rat Model through Improving Insulin Resistance via the IRS-1/PI3K/Akt/GSK-3β Pathway: A Comparative Study with Metformin

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(16), С. 3064 - 3077

Опубликована: Авг. 9, 2024

Polycystic ovary syndrome (PCOS) is an intricate endocrine disorder that targets millions of women globally. Recent research has drawn attention to its association with cognitive impairment and Alzheimer's disease (AD) risk, yet the exact mechanism remains elusive. This study aimed explore potential role PCOS-associated insulin resistance (IR) inflammation in linking PCOS AD pathogenesis. It additionally investigated therapeutic merits pterostilbene (PTS) ameliorating associated deficits comparison metformin (MET). Rats were divided into five groups; vehicle group, PTS group [30 mg/kg, per os (p.o.) for 13 days], remaining three groups received letrozole (1 p.o. 21 days) represent PCOS, + MET (300 days), groups, respectively. Behavioral tests conducted, along a histopathological investigation brains ovaries. Assessment serum hormonal profile hippocampal IRS-1/PI3K/AKT/GSK-3β signaling pathway components performed. rats exhibited improved sensitivity profile, besides enhanced neurobehavioral performance findings. These effects may be attributed modulation pathway, reducing GSK-3β activity, mitigating Tau hyperphosphorylation Aβ accumulation brain. Likewise, attenuated nuclear factor kappa B-mediated reversed AChE elevation, suggesting multifaceted neuroprotective effects. Comparatively, showed outcomes similar those most parameters. The obtained findings validated dysregulated detrimentally affects function, which halted by PTS, unveiling as novel therapy related deficits.

Язык: Английский

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Anisodamine ameliorates crystalline silica-exposed pulmonary inflammation and fibrosis via the α7nAChR/JAK2/STAT3 signaling pathway

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 289, С. 117534 - 117534

Опубликована: Дек. 11, 2024

Язык: Английский

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Immunotoxicology of Drugs of Abuse

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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