Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(22)
Опубликована: Ноя. 1, 2024
Abstract
Shenmai
injection
(SMI)
is
widely
used
in
the
clinical
treatment
of
sepsis,
but
its
mechanism
not
yet
clear.
This
study
aimed
to
explore
molecular
through
network
pharmacology,
bioinformatics,
and
docking
technologies.
The
active
ingredients
targets
SMI
were
screened
traditional
Chinese
medicine
databases
Swiss
Target
Prediction
database,
respectively.
disease
genes
searched
using
GEO
GeneCards
databases,
Venn
mapping
was
screen
potential
therapeutic
targets.
key
selected
Cytoscape
3.9.1
software.
BioGPS
database
evaluate
expression
these
tissues/cells.
DAVID
for
enrichment
analysis.
Molecular
technology
interaction
between
core
ingredients.
122
28
identified.
Forty‐six
showed
highly
specific
40
PI3K‐AKT,
RAP1,
MAPK
signalling
pathways
are
enriched.
results
good
interactions.
systematically
analysed
treating
involving
multiple
pathways,
possibly
related
anti‐inflammatory,
anti‐oxidative
stress,
immune
regulation,
providing
reference
value
future
basic
research
sepsis.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116515 - 116515
Опубликована: Апрель 2, 2024
Mesenchymal
stem
cell
exosome
(MSCs-exo)
is
a
class
of
products
secreted
by
mesenchymal
cells
(MSCs)
that
contain
various
biologically
active
substances.
MSCs-exo
promising
alternative
to
MSCs
due
their
lower
immunogenicity
and
lack
ethical
constraints.
Ginsenoside
Rh2
(Rh2)
hydrolyzed
component
the
primary
substance
ginsenosides.
has
variety
pharmacological
functions,
including
anti-inflammatory,
anti-tumor,
antioxidant.
Studies
have
demonstrated
gut
microbiota
metabolites
are
critical
in
developing
rheumatoid
arthritis
(RA).
In
this
study,
we
constructed
collagen-induced
(CIA)
model
rats.
We
used
combined
with
treat
CIA
To
observe
effect
on
joint
inflammation,
rat
feces
were
collected
for
16
rRNA
amplicon
sequencing
untargeted
metabolomics
analysis.
The
results
showed
index
score
swelling
rats
treated
combination
significantly
than
those
alone
groups.
ameliorated
disturbed
regulation
Candidatus_Saccharibacteria
Clostridium_XlVb
may
be
most
critical.
enhanced
therapeutic
compared
-alone
group.
Furthermore,
significant
changes
observed
group,
these
differentially
altered
act
as
messengers
host-microbiota
interactions.
These
differential
enriched
into
relevant
metabolic
pathways,
revealing
possible
pathways
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Апрель 26, 2024
Ginsenoside
Rh2
(G-Rh2),
a
steroidal
compound
extracted
from
roots
of
ginseng,
has
been
extensively
studied
in
tumor
therapy.
However,
its
specific
regulatory
mechanism
non-small
cell
lung
cancer
(NSCLC)
is
not
well
understood.
Pyruvate
dehydrogenase
kinase
4
(PDK4),
central
regulator
cellular
energy
metabolism,
highly
expressed
various
malignant
tumors.
We
investigated
the
impact
G-Rh2
on
progression
NSCLC
and
how
it
regulated
PDK4
to
influence
aerobic
glycolysis
mitochondrial
function.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(26), С. 14727 - 14746
Опубликована: Июнь 22, 2024
:
Following
spinal
cord
injury
(SCI),
autophagy
plays
a
positive
role
in
neuronal
protection,
whereas
pyroptosis
triggers
an
inflammatory
response.
Ginsenoside-Rh2
(GRh2),
known
for
its
neuroprotective
effects,
is
considered
promising
drug.
However,
the
exact
molecular
mechanisms
underlying
these
protective
effects
remain
unclear.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 12, 2024
Ginsenosides,
the
primary
bioactive
ingredients
derived
from
root
of
Panax
ginseng,
are
eagerly
in
demand
for
tumor
patients
as
a
complementary
and
alternative
drug.
Ginsenosides
have
increasingly
become
“hot
topic”
recent
years
due
to
their
multifunctional
role
treating
colorectal
cancer
(CRC)
regulating
microenvironment
(TME).
Emerging
experimental
research
on
ginsenosides
treatment
immune
regulation
CRC
has
been
published,
while
no
review
sums
up
its
specific
microenvironment.
Therefore,
this
paper
systematically
introduces
how
affect
TME,
specifically
by
enhancing
response,
inhibiting
activation
stromal
cells,
altering
hallmarks
cells.
In
addition,
we
discuss
impact
physicochemical
properties
Furthermore,
application
clinical
efficacy
patient
immunity
prolonging
survival.
The
future
perspectives
ginsenoside
drug
also
provided.
This
hopes
open
new
horizon
Traditional
Chinese
Medicine
monomers.
The American Journal of Chinese Medicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 25
Опубликована: Март 18, 2025
Myocardial
infarction
(MI)
is
a
significant
threat
to
human
health
worldwide.
Following
MI,
cardiomyocytes
(CMs)
undergo
pyroptosis,
exacerbating
the
damage
caused
by
infarction.
Ginseng
may
play
role
in
alleviating
CM
pyroptosis.
However,
further
exploration
needed
regarding
its
main
active
ingredients
and
effects.
By
employing
network
pharmacology
on
of
ginseng,
MI
molecular
docking
between
such
pyroptosis-related
proteins,
we
screened
for
ingredient
ginseng.
Through
docking,
identified
ginsenoside
Rh2,
which
acts
cell
as
most
likely
that
stably
binds
proteins.
We
subsequently
constructed
neonatal
rat
oxygen–glucose
deprivation
(OGD)
model
vitro
an
mouse
vivo.
Ginsenoside
Rh2
was
administered,
with
losartan
used
positive
control.
In
OGD
model,
increased
viability
primary
CMs
mitigated
OGD-induced
vivo
reduced
decreased
infarct
size,
improved
cardiac
function.
Our
study
provides
novel
therapeutic
strategy
attenuating
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3867 - 3867
Опубликована: Апрель 19, 2025
Medicinal
plants,
recognized
as
significant
natural
resources,
have
gained
prominence
in
response
to
the
increasing
global
demand
for
herbal
medicines,
necessitating
large-scale
production
of
these
plants
and
their
derivatives.
are
exposed
a
variety
internal
external
factors
that
interact
influence
biosynthesis
accumulation
secondary
metabolites.
With
rapid
development
omics
technologies
such
genomics,
transcriptomics,
proteomics,
metabolomics,
multi-omics
become
important
tools
revealing
complexity
functionality
organisms.
They
conducive
further
uncovering
biological
activities
metabolites
medicinal
clarifying
molecular
mechanisms
underlying
Also,
artificial
intelligence
(AI)
technology
accelerates
comprehensive
utilization
high-dimensional
datasets
offers
transformative
potential
analysis.
However,
there
is
currently
no
systematic
review
summarizing
genomic
metabolite
plants.
Safflower
(Carthamus
tinctorius
L.)
has
rich
diverse
bioactive
flavonoids,
among
which
Hydroxysafflor
yellow
A
(HSYA)
specific
safflower
emerging
medication
treating
wide
range
diseases.
Hence,
progress
been
made
study
an
excellent
example
regulation
recent
years.
Here,
we
on
understanding
main
at
level,
summarize
various
types
contents,
with
particular
focus
flavonoids.
This
aims
provide
insight
into
regulatory
from
perspective
genomics.
