Phylodynamic of SARS-CoV-2 during the second wave of COVID-19 in Peru DOI Creative Commons
Santiago Justo Arévalo, Carmen Sofia Uribe Calampa, Cinthy L. Jiménez-Silva

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июнь 15, 2023

Abstract At over 0.6% of the population, Peru has one highest SARS-CoV-2 mortality rate in world. Much effort to sequence genomes been done this country since mid-2020. However, an adequate analysis dynamics variants concern and interest (VOCIs) is missing. We investigated COVID-19 pandemic with a focus on second wave, which had greatest case fatality rate. The wave was dominated by Lambda Gamma. Analysis origin shows that it most likely emerged before (June–November, 2020). After its emergence reached Argentina Chile from where locally transmitted. During Peru, we identify coexistence two three Gamma sublineages. sublineages center whereas more originated north-east mid-east. Importantly, observed played prominent role transmitting other regions within Peru.

Язык: Английский

The effect of SARS-CoV-2 vaccination on post-acute sequelae of COVID-19 (PASC): A prospective cohort study DOI Creative Commons
Elke Wynberg, Alvin X. Han, Anders Boyd

и другие.

Vaccine, Год журнала: 2022, Номер 40(32), С. 4424 - 4431

Опубликована: Июнь 7, 2022

Symptoms of post-acute sequelae COVID-19 (PASC) may improve following SARS-CoV-2 vaccination. However few prospective data that also explore the underlying biological mechanism are available. We assessed effect vaccination on symptomatology participants with PASC, and compared antibody dynamics between those without PASC.

Язык: Английский

Процитировано

74
The collateral damage of COVID-19 to cardiovascular services: a meta-analysis DOI Open Access
Ramesh Nadarajah, Jianhua Wu, Ben Hurdus

и другие.

European Heart Journal, Год журнала: 2022, Номер 43(33), С. 3164 - 3178

Опубликована: Апрель 21, 2022

The effect of the COVID-19 pandemic on care and outcomes across non-COVID-19 cardiovascular (CV) diseases is unknown. A systematic review meta-analysis was performed to quantify investigate for variation by CV disease, geographic region, country income classification time course pandemic.

Язык: Английский

Процитировано

63
Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to? DOI Creative Commons
Altijana Hromić‐Jahjefendić, Debmalya Barh, Vladimir N. Uversky

и другие.

Vaccines, Год журнала: 2023, Номер 11(2), С. 208 - 208

Опубликована: Янв. 17, 2023

According to the WHO, as of January 2023, more than 850 million cases and over 6.6 deaths from COVID-19 have been reported worldwide. Currently, death rate has reduced due decreased pathogenicity new SARS-CoV-2 variants, but major factor in rates is administration 12.8 billion vaccine doses globally. While vaccines are saving lives, serious side effects after vaccinations for several premature non-communicable diseases (NCDs). However, adverse events low number. The scientific community must investigate entire spectrum COVID-19-vaccine-induced complications so that necessary safety measures can be taken, current re-engineered avoid or minimize their effects. We describe depth severe metabolic, mental, neurological disorders; cardiovascular, renal, autoimmune diseases, reproductive health issues detected whether these causal incidental. In any case, it become clear benefits outweigh risks by a large margin. pre-existing conditions vaccinated individuals need taken into account prevention treatment events.

Язык: Английский

Процитировано

19
COVID-19 in Pakistan: A national analysis of five pandemic waves DOI Creative Commons
Taimoor Ahmad, Mujahid Abdullah, Abdul Mueed

и другие.

PLoS ONE, Год журнала: 2023, Номер 18(12), С. e0281326 - e0281326

Опубликована: Дек. 29, 2023

Objectives The COVID-19 pandemic showed distinct waves where cases ebbed and flowed. While each country had slight, nuanced differences, lessons from wave with country-specific details provides important for prevention, understanding medical outcomes the role of vaccines. This paper compares key characteristics five different in Pakistan. Methods Data was sourced daily national situation reports (Sitreps) prepared by National Emergency Operations Centre (NEOC) Islamabad. We use specific criteria to define waves. start is marked day lowest number preceding a sustained increase, while end following 7-days decline, which should be lower than 7 days it. Key variables such as tests, cases, deaths their rates change peak then trough are used draw descriptive comparisons. Additionally, linear regression model estimates new Results Pakistan saw waves, displayed typical topology complete infectious disease epidemic. time wave-start became progressively shorter, wave-peak trough, longer. Each appears also getting except 4, lasted longer 3. A one percent increase vaccinations decreased 0.38% (95% CI: -0.67, -0.08) 5 association statistically significant. Conclusion that must interpreted context level response variant driving indicators suggest preventive measures kept pace disease. Waves 1 2 were mainly about prevention learning how clinically manage patients. Vaccination started late during 3 its impact on hospitalizations visible 5. highly virulent strains Alpha/B.1.1.7 Delta/B.1.617.2 variants milder but more Omicron/B.1.1.529 apparent.

Язык: Английский

Процитировано

18
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease DOI Creative Commons
Chunsong Hu

Natural Products and Bioprospecting, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 29, 2024

Abstract Marine natural products (MNPs) and marine organisms include sea urchin, squirts or ascidians, cucumbers, snake, sponge, soft coral, algae, microalgae. As vital biomedical resources for the discovery of drugs, bioactive molecules, agents, these MNPs have potentials antioxidant, anti-infection, anti-inflammatory, anticoagulant, anti-diabetic effects, cancer treatment, improvement human immunity. This article reviews role on anti-infection coronavirus, SARS-CoV-2 its major variants (such as Delta Omicron) well tuberculosis, H. Pylori, HIV infection, promising infection related cardiovascular disease (irCVD), diabetes, cancer. The anti-inflammatory mechanisms current against are also discussed. Since use other chemical agents COVID-19 treatment associated with some adverse effects in system, more therapeutic advantages. Herein, it’s time to protect this ecosystem better sustainable development new era ocean economy. huge, novel irCVD, potential may be through multiple targets pathways regulating immunity inhibiting inflammation. In conclusion, worthy translational research further clinical application. Graphical

Язык: Английский

Процитировано

8
A stochastic particle extended SEIRS model with repeated vaccination: Application to real data of COVID‐19 in Italy DOI Creative Commons
Vasileios E. Papageorgiou, George Tsaklidis

Mathematical Methods in the Applied Sciences, Год журнала: 2024, Номер 47(7), С. 6504 - 6538

Опубликована: Фев. 22, 2024

The prediction of the evolution epidemics plays an important role in limiting transmissibility and burdensome consequences infectious diseases, which leads to employment mathematical modeling. In this paper, we propose a stochastic particle filtering extended SEIRS model with repeated vaccination time‐dependent parameters, aiming efficiently describe demanding dynamics time‐varying epidemics. validity our is examined using daily records COVID‐19 Italy for period 525 days, revealing notable capacity uncover hidden pandemic. main findings include estimation asymptomatic cases, well‐known feature current Unlike other proposed models that employ extra compartments force proportion significantly increase model's complexity, approach evaluation without additional computational burden. Other confirm appropriateness robustness are its parameter more ICU‐admitted cases compared official during most prevalent infection wave January 2022, attributed intensified admissions may have led full occupancy ICUs. As vast majority datasets contain time series total recovered vaccinated statistical algorithm estimate currently protected through cases. This necessity arises from attenuation antibodies after vaccination/infection necessary long‐time interval predictions. Finally, not only present novel epidemiological test efficiency but also investigate properties, such as existence stability epidemic equilibria, giving new insights literature. latter provides details concerning system's long‐term behavior, while conclusions drawn index provide perspectives on severity future

Язык: Английский

Процитировано

7
Death after the Administration of COVID-19 Vaccines Approved by EMA: Has a Causal Relationship Been Demonstrated? DOI Creative Commons
Aniello Maiese, A. Baronti, A Manetti

и другие.

Vaccines, Год журнала: 2022, Номер 10(2), С. 308 - 308

Опубликована: Фев. 16, 2022

More than eight billion doses of COVID-19 vaccines have been administered globally so far and 44.29% people are fully vaccinated. Pre-authorization clinical trials were carried out the safety is still continuously monitored through post-commercialization surveillance. However, some afraid vaccine side effects, claiming they could lead to death, hesitate get Herein, a literature review COVID-19-vaccine-related deaths has according PRISMA standards understand if there causal relationship between vaccination death highlight real extent such events. There 55 cases after reported excluded in 17 cases. In remaining cases, link was not specified (8) or considered possible (15), probable (1), very probable/demonstrated (14). The causes among these were: vaccine-induced immune thrombotic thrombocytopenia (VITT) (32), myocarditis (3), ADEM myocardial infarction rhabdomyolysis (1). demonstration obvious, more studies, especially with post-mortem investigations, needed deepen understanding pathophysiological mechanisms fatal effects. any event, given scarcity benefits outweigh risks scientific community needs be cohesive asserting that fundamental containing spread SARS-CoV-2.

Язык: Английский

Процитировано

28
An improved epidemiological-unscented Kalman filter (hybrid SEIHCRDV-UKF) model for the prediction of COVID-19. Application on real-time data DOI Open Access
Vasileios E. Papageorgiou, George Tsaklidis

Chaos Solitons & Fractals, Год журнала: 2022, Номер 166, С. 112914 - 112914

Опубликована: Ноя. 21, 2022

Язык: Английский

Процитировано

25
Unveiling the Impact of COVID-19 Vaccines: A Meta-Analysis of Survival Rates Among Patients in the United States Based on Vaccination Status DOI Open Access

Anderson E Ikeokwu,

Rebecca Lawrence,

Egbaoghene D Osieme

и другие.

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Авг. 10, 2023

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a significant number of cases and deaths worldwide. Vaccination is most effective preventive measure against disease. This study aimed to assess mortality rates patients United States effectiveness Pfizer (Pfizer, NY, USA), Moderna (Moderna, MA, Janssen (Johnson & Johnson, NJ, USA) vaccines preventing mortality. A systematic review meta-analysis were conducted following Preferred Reporting Items for Systematic reviews Meta-Analyses (PRISMA-2020) guidelines. Eligible studies reporting on patient outcomes included. search was performed PubMed, Cochrane, Google Scholar databases. data extracted, risk ratios (RR) calculated outcomes. analysis using Review Manager software, bias assessments Joanna Briggs Institute (JBI) Meta-Analysis tools. total seven with 21,618,297 included meta-analysis. odds ratio (OR) among unvaccinated compared vaccinated 2.46 (95% CI: 1.71-3.53), indicating that times more likely die from COVID-19. findings this support vaccination reducing infected individuals. Unvaccinated had significantly higher patients. remains crucial strategy mitigate severity disease reduce rates. Efforts should be made address vaccine hesitancy ensure widespread coverage.

Язык: Английский

Процитировано

14
COVID-19 Recovery Patterns Across Alpha (B.1.1.7) and Delta (B.1.617.2) Variants of SARS-CoV-2 DOI Creative Commons
Nitya Kumar,

Suha Quadri,

Abdulla Alawadhi

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Фев. 14, 2022

B.1.1.7 (alpha) and B.1.617.2 (delta) variants of concern for SARS-CoV-2 have been reported to differential infectivity pathogenicity. Difference in recovery patterns across these the interaction with vaccination status has not population-based studies.The objective this research was study length stay temporal trends RT-PCR cycle times (Ct) alpha delta between vaccinated unvaccinated individuals.Participants consisted patients admitted national COVID-19 treatment facilities if they had a positive test SARS-CoV-2, analysis performed (using whole genome sequencing). Information on status, age, sex, four consecutive tests conducted during hospital stay, total each participant were ascertained from electronic medical records.Patients infected variant younger (mean age = 35years vs 39 years alpha, p<0.001) lesser coverage (54% 72% p<0.001). Ct values similar both at baseline test; however by fourth test, significantly lower (27 29, p=0.05). Length higher (3 days 2.9 variant) as well (5.2 4.4 variant, Hazards discharge after adjusting sex infections (HR=1.2, 95% CI: 1.01-1.41, p=0.029).Patients found slower indicated longer shedding virus compared infections, trend consistent patients.

Язык: Английский

Процитировано

23