Sensing and Bio-Sensing Research, Год журнала: 2025, Номер unknown, С. 100797 - 100797
Опубликована: Апрель 1, 2025
Язык: Английский
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(9), С. 10998 - 11007
Опубликована: Апрель 29, 2024
Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.
Язык: Английский
Процитировано
39
Science Advances, Год журнала: 2025, Номер 11(5)
Опубликована: Янв. 31, 2025
The hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) poses a substantial challenge to the global health care. However, mechanism behind its evolution and transmission remain elusive. Here, four virulence plasmid types were identified from 310 hv-CRKP isolates collected nationwide during 2017–2018, based on their aerobactin ( iuc locus) lineage IncFIB replicons. Notably, pIUC1-IncFIB(K) 37 pIUC1-IncFIB(Mar), representing two epidemic plasmids in Asia Europe, respectively, accounted for >90% of episodes. Analysis 494 K. (376 2010–2013; 118 2017–2018) 2578 public genomes indicated notable role IncFIB(Mar) emergence spread. Conjugation assays showed helper could efficiently transfer into strain uniquely retromobilize with back CRKP. Thereafter, either lost rapidly or recombined , generating hybrid pIUC1-IncFIB(Mar) plasmid. Our findings elucidated formation, evolution, dissemination trajectories major strains different regions.
Язык: Английский
Процитировано
2
Microbiological Research, Год журнала: 2024, Номер 288, С. 127839 - 127839
Опубликована: Авг. 11, 2024
Язык: Английский
Процитировано
11
Pharmaceuticals, Год журнала: 2024, Номер 17(9), С. 1206 - 1206
Опубликована: Сен. 12, 2024
The rise of antibiotic resistance and the dwindling antimicrobial pipeline have emerged as significant threats to public health. emergence carbapenem-resistant
Язык: Английский
Процитировано
9
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Янв. 24, 2025
Background The rapid emergence of multidrug-resistant Klebsiella pneumoniae (MDR K. ) is a major public health and economic burden worldwide. Various resistance mechanisms complicate treatment, leading to increased morbidity mortality. Despite numerous studies conducted in Gulf Health Council (GHC) countries, the molecular epidemiology MDR remains not clearly defined. This systematic review aims analyze antimicrobial genes across GHC countries. Methods A search was using PubMed, ScienceDirect, OpenMD for articles published up March 15, 2023. strategy focused on bacterial name, drug-resistance genotypes, followed PRISMA guidelines, with two independent reviewers assessing risk bias NIH Study Quality Assessment tools. Results primary yielded 1,663 studies, which 67 met inclusion criteria. Saudi Arabia contributed most 41 (61.1%), by Kuwait 7 (10.4%), UAE 6 (9%) studies. Oman Qatar each 4 (6%), Bahrain three (4.5%). remaining (4.4%) were from multiple exhibited considerable heterogeneity detection methods, target genes, mechanisms. Notably, only one environmental study UAE, community-based Kuwait, while clinical samples. patterns observed between countries different years within same country. highlighted widespread prevalence ESBL particularly bla TEM CTX-M-15 , carbapenemase such as OXA-48 NDM-1 KPC-2 . Additionally, colistin through mcr-1 gene mgrB mutations reported posing significant challenge. Conclusion Data shows gaps, community Limited genome-based investigations hinder comprehensive AMR surveillance. Implementing standardized methodologies fostering surveillance programs at both national regional levels are essential effectively combating spread improving outcomes region.
Язык: Английский
Процитировано
1
hLife, Год журнала: 2024, Номер unknown
Опубликована: Июнь 1, 2024
The emergence of hypervirulence (hv) and carbapenem resistance (CR) as distinct evolutionary directions for Klebsiella pneumoniae presents a significant threat in clinical settings. However, recent years, there has been growing identification K. strains that integrate both phenotypes, resulting severe outcomes. Carbapenem-resistant hypervirulent (CRhvKP) typically emerges through the acquisition plasmids carrying either virulence or CR-encoded genes by carbapenem-resistant pneumoniae. Furthermore, hybrid plasmid can confer combination CR hv. CRhvKP cause variety infections, including pneumonia, urinary tract bloodstream liver abscesses, other related conditions. While sequence type 11 (ST11) dominates majority China, molecular factors responsible success ST11 largely remain unknown. Here, we provide an overview current understanding variation distribution crucial determinants, mechanisms driving merging hv CR, potential influencing epidemiological CRhvKP. This research aims to contribute comprehensive complexities surrounding It is imperative underscore development therapies, precision medicine, vaccine strategies pivotal approaches effectively combating Considering widespread prevalence CRhvKP, prioritized, multifaceted approach encompassing infection control, active surveillance, innovative therapeutics essential.
Язык: Английский
Процитировано
7
Drug Resistance Updates, Год журнала: 2024, Номер 77, С. 101124 - 101124
Опубликована: Авг. 2, 2024
Язык: Английский
Процитировано
5
Microbial Biotechnology, Год журнала: 2024, Номер 17(10)
Опубликована: Окт. 1, 2024
The emergence of new techniques in both microbial biotechnology and artificial intelligence (AI) is opening up a completely field for monitoring sometimes even controlling the evolution pathogens. However, now famous generative AI extracts reorganizes prior knowledge from large datasets, making it poorly suited to predictions an unreliable future. In contrast, unfamiliar perspective can help us identify key issues related technologies, such as those arising synthetic biology, whilst revisiting old views or including generator abduction resource. This could enable dangerous situations that are bound emerge not-too-distant future, prepare ourselves anticipate when where they will occur. Here, we emphasize fact amongst many causes pathogen outbreaks, often driven by explosion human population, laboratory accidents major cause epidemics. review, limited animal pathogens, concludes with discussion potential epidemic origins based on unusual organisms associations have rarely been highlighted studied.
Язык: Английский
Процитировано
5
Annals of Clinical Microbiology and Antimicrobials, Год журнала: 2024, Номер 23(1)
Опубликована: Ноя. 7, 2024
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an emerging global threat, whereas its epidemiological characteristics in children are rarely reported. This study aims to analyze clinical and of CRKP from Henan, China.
Язык: Английский
Процитировано
4
Infection and Drug Resistance, Год журнала: 2025, Номер Volume 18, С. 83 - 92
Опубликована: Янв. 1, 2025
Background: Therefore, the objectives of this study were to investigate prevalence carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) in Fujian Medical University Union Hospital, identify their genetic characters, characterize resistance profiles, and risk factors for infection improve prevention treatment strategies CR-hvKp area. Methods: Between January 2021 2022, clinically identified (CRKp) isolates collected. A PCR assay was used detect K capsule type, virulence genes, carbapenemase membrane pore protein. ERIC-PCR carried out homology analysis. Antimicrobial susceptibility test determine drug resistance. Logistic multivariate regression analysis conducted confirm infection. Results: In total, 239 CRKp obtained. The genes with highest detection rates mrkD, iucA , rmpA2 . Of these isolates, 54 (22.59%) both thus classifying them as CR-hvKp. All bla KPC Furthermore, capsular serotypes K64 (94.44%) K47 (3.70%) detected. Resistance observed against most common antibiotics, exception complete sensitivity ceftazidime-avibactam. indicated a potential clonal spread among Multivariate found that changing beds factor Conclusion: Currently, hospital predominantly carries harbors Our patient an independent Keywords: carbapenem-resistant, hypervirulent, virulence, resistance,
Язык: Английский
Процитировано
0