Environmental Toxicology,
Год журнала:
2023,
Номер
38(10), С. 2416 - 2428
Опубликована: Июнь 22, 2023
Abstract
The
environmental
pollutant
bisphenol
A
(BPA),
used
in
the
manufacture
of
plastic
packaging
materials
for
various
diets,
is
widely
distributed
environment
and
causes
severe
hepatotoxicity
by
inducing
oxidative
stress.
Artemisia
argyi
essential
oil
(AAEO),
a
volatile
component
isolated
from
H.Lév
.
&
Vaniot
,
has
pharmacological
effects,
especially
hepatoprotective
actions.
However,
potential
effect
AAEO
BPA
induced
not
been
characterized.
First,
we
analyzed
chemical
composition
gas
chromatography–mass
spectrometry.
Herein,
investigated
on
hepatic
metabolic
changes
mice
exposed
to
BPA.
Results
showed
that
compared
with
group,
could
reduce
level
liver
function
enzymes
serum,
ameliorate
lesions
fibrosis.
Additionally,
20
differential
metabolites
screened
metabolomics
were
mainly
involved
reprogramming
glutathione
metabolism,
purine
polyunsaturated
fatty
acid
synthesis.
Moreover,
ferroptosis
BPA,
as
demonstrated
reducing
xanthine
oxidase
activity,
up‐regulating
activities
peroxidase
4
(GPX4),
superoxide
dismutase,
catalase
expression
SLC7A11
promote
synthetic,
while
inhibiting
transferrin
receptor
1
(TFR1)
accumulation
Fe
2+
cells.
Therefore,
our
study
identified
protectant
against
BPA‐induced
reversing
occurrence
ferroptosis.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115263 - 115263
Опубликована: Авг. 2, 2023
In
addition
to
the
anti-diabetic
effect
of
metformin,
a
growing
number
studies
have
shown
that
metformin
has
some
exciting
properties,
such
as
anti-oxidative
capabilities,
anticancer,
genomic
stability,
anti-inflammation,
and
anti-fibrosis,
which
potent,
can
treat
other
disorders
than
diabetes
mellitus.
We
aimed
describe
review
protective
antidotal
efficacy
against
biologicals,
chemicals,
natural,
medications,
pesticides,
radiation-induced
toxicities.
A
comprehensive
search
been
performed
from
Scopus,
Web
Science,
PubMed,
Google
Scholar
databases
inception
March
8,
2023.
All
in
vitro,
vivo,
clinical
were
considered.
Many
suggest
affects
diseases
diabetes.
It
is
radioprotective
chemoprotective
drug
also
viral
bacterial
diseases.
be
used
inflammation-related
apoptosis-related
abnormalities
toxins
lower
their
effects.
Besides
lowering
blood
sugar,
attenuate
effects
on
body
weight,
inflammation,
apoptosis,
necrosis,
caspase-3
activation,
cell
viability
survival
rate,
reactive
oxygen
species
(ROS),
NF-κB,
TNF-α,
many
interleukins,
lipid
profile,
enzymes
activity
catalase
superoxide
dismutase.
reduce
histopathological
damages
induced
by
kidneys,
liver,
colon.
However,
trials
human
are
needed
before
using
therapeutic
agent
Biochemical Journal,
Год журнала:
2021,
Номер
478(19), С. 3485 - 3504
Опубликована: Окт. 6, 2021
Hydrogen
sulfide
(H2S)
modulates
many
biological
processes,
including
ageing.
Initially
considered
a
hazardous
toxic
gas,
it
is
now
recognised
that
H2S
produced
endogenously
across
taxa
and
key
mediator
of
processes
promote
longevity
improve
late-life
health.
In
this
review,
we
consider
the
developments
in
our
understanding
gaseous
signalling
molecule
context
health
disease,
discuss
potential
mechanisms
through
which
can
influence
central
to
ageing
highlight
emergence
novel
H2S-based
therapeutics.
We
also
major
challenges
may
potentially
hinder
development
such
therapies.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 10, 2024
Abstract
Background
Bisphenol
A
(BPA)
levels
are
high
in
women
with
polycystic
ovary
syndrome
(PCOS).
The
mechanism
by
which
BPA
induces
abnormal
glucose
metabolism
PCOS
patients
is
largely
unknown.
Methods
Serum
and
urine
samples
were
collected
from
without
(control)
at
the
reproductive
medicine
center
informed
consent.
Non-PCOS
who
received
vitro
fertilization
recruited
for
collection
of
ovarian
follicular
fluid
granular
cells.
Wild-type
C57BL/6
AhR
−/−
mice
used
to
verify
effects
on
PCOS.
Real-time
PCR,
western
blotting,
ELISA
conducted
analyze
function
BPA.
Chip-qPCR
verified
role
GLUT4
transcription.
Flow
cytometry
was
performed
determine
uptake.
Results
positive
correlation
observed
between
concentration
serum
patients.
aggravated
changes
metabolism,
impaired
fertility,
increased
body
fat.
Mechanistically,
we
showed
that
activated
led
decreased
transport
via
downregulation
Therefore,
use
inhibitors
or
knockout
could
effectively
rescue
BPA-induced
metabolic
disorders
mice.
Conclusions
Our
results
revealed
suppressed
expression
induced
activating
AhR,
causing
insulin
resistance,
thus
a
potential
contributor
development
be
new
therapeutic
target
Journal of Cellular Physiology,
Год журнала:
2022,
Номер
237(8), С. 3292 - 3304
Опубликована: Май 26, 2022
Abstract
Bisphenol
A
(BPA)
in
the
environment
can
have
deleterious
effects
on
humans
and
animals.
BPA
exert
nephrotoxicity
by
inducing
oxidative
stress.
Selenium
(Se)
deficiency
specifically
impair
kidney
tissues
additionally
show
a
synergistic
effect
toxicity
of
several
environmental
chemicals.
However,
toxic
chicken
whether
Se
produces
remain
poorly
understood.
Herein,
we
established
exposure
models
model
vivo
vitro,
described
discovery
path
aggravation
apoptosis
necroptosis
Se‐deficient
kidneys
via
regulation
stress
phosphatidylinositol
3‐kinase/threonine
kinase
(PI3K/AKT)
signaling
pathway.
We
found
that
increased
reactive
oxygen
species
malondialdehyde
levels,
reduced
activities
catalase,
GPx,
superoxide
dismutase,
downregulated
PI3K
AKT
expressions,
activated
Bcl/Bax‐Caspase
9‐Caspase
3,
receptor‐interacting
protein
1/mixed
lineage
domain‐like
pathways,
resulting
kidney.
In
addition,
significantly
promoted
expression
renal
BPA‐exposed
kidneys.
Altogether,
our
results
showed
aggravates
PI3K/AKT
Our
findings
elucidate
mechanism
exacerbation
chickens
will
provide
great
significance
for
protection
ecological
animal
health.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1083 - 1083
Опубликована: Янв. 5, 2023
Obesogenic
endocrine-disrupting
chemicals
(EDCs)
belong
to
the
group
of
environmental
contaminants,
which
can
adversely
affect
human
health.
A
growing
body
evidence
supports
that
chronic
exposure
EDCs
contribute
a
rapid
increase
in
obesity
among
adults
and
children,
especially
wealthy
industrialized
countries
with
high
production
widely
used
industrial
such
as
plasticizers
(bisphenols
phthalates),
parabens,
flame
retardants,
pesticides.
The
main
source
obesogenic
is
through
diet,
particularly
consumption
contaminated
food
meat,
fish,
fruit,
vegetables,
milk,
dairy
products.
promote
by
stimulating
adipo-
lipogenesis
target
cells
adipocytes
hepatocytes,
disrupting
glucose
metabolism
insulin
secretion,
impacting
hormonal
appetite/satiety
regulation.
In
vitro
models
still
play
an
essential
role
investigating
potential
obesogens.
review
aimed
provide
information
on
currently
available
two-dimensional
(2D)
animal
cell
applied
for
studying
mechanisms
action
various
contaminants.
advantages
limitations
representing
crucial
endocrine
tissue
(adipose
tissue)
organs
(liver
pancreas)
involved
etiology
metabolic
diseases,
are
evaluate
effects
their
disruption
activity,
were
thoroughly
critically
discussed.
