Hepatoprotective effect of Artemisia Argyi essential oil on bisphenol A‐induced hepatotoxicity via inhibition of ferroptosis in mice DOI
Weiqi Cui, Hui Zhou, Jingxian Zhang

et al.

Environmental Toxicology, Journal Year: 2023, Volume and Issue: 38(10), P. 2416 - 2428

Published: June 22, 2023

Abstract The environmental pollutant bisphenol A (BPA), used in the manufacture of plastic packaging materials for various diets, is widely distributed environment and causes severe hepatotoxicity by inducing oxidative stress. Artemisia argyi essential oil (AAEO), a volatile component isolated from H.Lév . & Vaniot , has pharmacological effects, especially hepatoprotective actions. However, potential effect AAEO BPA induced not been characterized. First, we analyzed chemical composition gas chromatography–mass spectrometry. Herein, investigated on hepatic metabolic changes mice exposed to BPA. Results showed that compared with group, could reduce level liver function enzymes serum, ameliorate lesions fibrosis. Additionally, 20 differential metabolites screened metabolomics were mainly involved reprogramming glutathione metabolism, purine polyunsaturated fatty acid synthesis. Moreover, ferroptosis BPA, as demonstrated reducing xanthine oxidase activity, up‐regulating activities peroxidase 4 (GPX4), superoxide dismutase, catalase expression SLC7A11 promote synthetic, while inhibiting transferrin receptor 1 (TFR1) accumulation Fe 2+ cells. Therefore, our study identified protectant against BPA‐induced reversing occurrence ferroptosis.

Language: Английский

Applications and influencing factors of the biochar-persulfate based advanced oxidation processes for the remediation of groundwater and soil contaminated with organic compounds DOI
Tianhao Liu, Bin Yao,

Zirui Luo

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 836, P. 155421 - 155421

Published: April 25, 2022

Language: Английский

Citations

63
Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins DOI Open Access
Amirhossein Malaekeh-Nikouei,

Sina Shokri-Naei,

Sobhan Karbas Foroushan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115263 - 115263

Published: Aug. 2, 2023

In addition to the anti-diabetic effect of metformin, a growing number studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which potent, can treat other disorders than diabetes mellitus. We aimed describe review protective antidotal efficacy against biologicals, chemicals, natural, medications, pesticides, radiation-induced toxicities. A comprehensive search been performed from Scopus, Web Science, PubMed, Google Scholar databases inception March 8, 2023. All in vitro, vivo, clinical were considered. Many suggest affects diseases diabetes. It is radioprotective chemoprotective drug also viral bacterial diseases. be used inflammation-related apoptosis-related abnormalities toxins lower their effects. Besides lowering blood sugar, attenuate effects on body weight, inflammation, apoptosis, necrosis, caspase-3 activation, cell viability survival rate, reactive oxygen species (ROS), NF-κB, TNF-α, many interleukins, lipid profile, enzymes activity catalase superoxide dismutase. reduce histopathological damages induced by kidneys, liver, colon. However, trials human are needed before using therapeutic agent

Language: Английский

Citations

27
Homocysteine and diabetes: Role in macrovascular and microvascular complications DOI
Emir Muzurović, Ivana Kraljević, Mirsala Solak

et al.

Journal of Diabetes and its Complications, Journal Year: 2020, Volume and Issue: 35(3), P. 107834 - 107834

Published: Dec. 31, 2020

Language: Английский

Citations

69
Hydrogen sulfide in ageing, longevity and disease DOI Creative Commons
Stephen E. Wilkie,

Gillian Borland,

Roderick N. Carter

et al.

Biochemical Journal, Journal Year: 2021, Volume and Issue: 478(19), P. 3485 - 3504

Published: Oct. 6, 2021

Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S produced endogenously across taxa and key mediator of processes promote longevity improve late-life health. In this review, we consider the developments in our understanding gaseous signalling molecule context health disease, discuss potential mechanisms through which can influence central to ageing highlight emergence novel H2S-based therapeutics. We also major challenges may potentially hinder development such therapies.

Language: Английский

Citations

42
Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway DOI
Cüneyt Çağlayan, Fatih Mehmet Kandemir, Adnan Ayna

et al.

Metabolic Brain Disease, Journal Year: 2022, Volume and Issue: 37(6), P. 1931 - 1940

Published: June 14, 2022

Language: Английский

Citations

34
Bisphenol a downregulates GLUT4 expression by activating aryl hydrocarbon receptor to exacerbate polycystic ovary syndrome DOI Creative Commons
Jing Shi, Kai-Lun Hu, Xiaoxue Li

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 10, 2024

Abstract Background Bisphenol A (BPA) levels are high in women with polycystic ovary syndrome (PCOS). The mechanism by which BPA induces abnormal glucose metabolism PCOS patients is largely unknown. Methods Serum and urine samples were collected from without (control) at the reproductive medicine center informed consent. Non-PCOS who received vitro fertilization recruited for collection of ovarian follicular fluid granular cells. Wild-type C57BL/6 AhR −/− mice used to verify effects on PCOS. Real-time PCR, western blotting, ELISA conducted analyze function BPA. Chip-qPCR verified role GLUT4 transcription. Flow cytometry was performed determine uptake. Results positive correlation observed between concentration serum patients. aggravated changes metabolism, impaired fertility, increased body fat. Mechanistically, we showed that activated led decreased transport via downregulation Therefore, use inhibitors or knockout could effectively rescue BPA-induced metabolic disorders mice. Conclusions Our results revealed suppressed expression induced activating AhR, causing insulin resistance, thus a potential contributor development be new therapeutic target

Language: Английский

Citations

7
Cineole regulates Wnt/β-catenin pathway through Nrf2/keap1/ROS to inhibit bisphenol A-induced apoptosis, autophagy inhibition and immunosuppression of grass carp hepatocytes DOI
Lu Chen, Dayong Tao, Fuchang Yu

et al.

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 131, P. 30 - 41

Published: Oct. 1, 2022

Language: Английский

Citations

28
Bisphenol A aggravates renal apoptosis and necroptosis in selenium‐deficient chickens via oxidative stress and PI3K/AKT pathway DOI
Huijie Chen, Yue Zhang,

Mengmeng Zou

et al.

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(8), P. 3292 - 3304

Published: May 26, 2022

Abstract Bisphenol A (BPA) in the environment can have deleterious effects on humans and animals. BPA exert nephrotoxicity by inducing oxidative stress. Selenium (Se) deficiency specifically impair kidney tissues additionally show a synergistic effect toxicity of several environmental chemicals. However, toxic chicken whether Se produces remain poorly understood. Herein, we established exposure models model vivo vitro, described discovery path aggravation apoptosis necroptosis Se‐deficient kidneys via regulation stress phosphatidylinositol 3‐kinase/threonine kinase (PI3K/AKT) signaling pathway. We found that increased reactive oxygen species malondialdehyde levels, reduced activities catalase, GPx, superoxide dismutase, downregulated PI3K AKT expressions, activated Bcl/Bax‐Caspase 9‐Caspase 3, receptor‐interacting protein 1/mixed lineage domain‐like pathways, resulting kidney. In addition, significantly promoted expression renal BPA‐exposed kidneys. Altogether, our results showed aggravates PI3K/AKT Our findings elucidate mechanism exacerbation chickens will provide great significance for protection ecological animal health.

Language: Английский

Citations

27
Application of In Vitro Models for Studying the Mechanisms Underlying the Obesogenic Action of Endocrine-Disrupting Chemicals (EDCs) as Food Contaminants—A Review DOI Open Access
Monika Kowalczyk, Jakub P. Piwowarski, Artur Wardaszka

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1083 - 1083

Published: Jan. 5, 2023

Obesogenic endocrine-disrupting chemicals (EDCs) belong to the group of environmental contaminants, which can adversely affect human health. A growing body evidence supports that chronic exposure EDCs contribute a rapid increase in obesity among adults and children, especially wealthy industrialized countries with high production widely used industrial such as plasticizers (bisphenols phthalates), parabens, flame retardants, pesticides. The main source obesogenic is through diet, particularly consumption contaminated food meat, fish, fruit, vegetables, milk, dairy products. promote by stimulating adipo- lipogenesis target cells adipocytes hepatocytes, disrupting glucose metabolism insulin secretion, impacting hormonal appetite/satiety regulation. In vitro models still play an essential role investigating potential obesogens. review aimed provide information on currently available two-dimensional (2D) animal cell applied for studying mechanisms action various contaminants. advantages limitations representing crucial endocrine tissue (adipose tissue) organs (liver pancreas) involved etiology metabolic diseases, are evaluate effects their disruption activity, were thoroughly critically discussed.

Language: Английский

Citations

15
Hepatoprotective effects of oridonin against bisphenol A induced liver injury in rats via inhibiting the activity of xanthione oxidase DOI
Xinying Wang, Ming Gao, Zihan Wang

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 770, P. 145301 - 145301

Published: Jan. 22, 2021

Language: Английский

Citations

32