Ecotoxicology
has
long
relied
on
assessing
the
hazard
potential
of
chemicals
through
traditional
in
vivo
testing
methods
to
understand
possible
risk
exposure
could
pose
ecological
taxa.
In
past
decade,
development
non-animal
new
approach
(NAMs)
for
chemical
and
quickly
grown.
These
are
often
cheaper
faster
than
toxicity
testing,
thus
amenable
high-throughput
(HTT),
resulting
large
datasets.
The
ToxCast/Tox21
HTT
programs
have
produced
vitro
data
thousands
covering
a
space
biological
activity.
relevance
these
mammalian
been
much
explored.
Interest
also
grown
using
evaluate
environmental
exposures
taxa
importance
such
as
fish,
aquatic
invertebrates,
etc.;
particularly
purpose
estimating
from
real-world
complex
mixtures.
Understanding
relationship
relative
sensitivity
NAMs
versus
standardized
ecotoxicological
whole
organism
models
is
key
component
performing
reliable
read-across
data.
this
work,
we
explore
between
ecotoxicity
several
publicly
available
databases
We
performed
case
studies
which
compare
how
different
datasets,
whether
or
ToxCast-based,
affects
conclusions
based
mixtures
derived
existing
large-scale
monitoring
Generally,
predictive
value
endpoints
(EPs)
was
poor
(r≤0.3).
Risk
conclusions,
including
identification
drivers
prioritized
sites,
were
when
vs.
The Science of The Total Environment,
Год журнала:
2023,
Номер
881, С. 163514 - 163514
Опубликована: Апрель 15, 2023
Pharmaceuticals
and
personal
care
products
(PPCPs)
are
incredibly
diverse
in
terms
of
chemical
structures,
physicochemical
properties,
modes
action,
making
their
environmental
impacts
challenging
to
assess.
New
prioritization
methodologies
have
emerged
that
compare
contaminant
monitoring
concentrations
multiple
toxicity
data
sources,
including
whole
organism
high-throughput
data,
develop
a
list
"high
priority"
chemicals
requiring
further
study.
We
applied
such
an
approach
assess
PPCPs
Hunting
Creek,
urban
tributary
the
Potomac
River
near
Washington,
DC,
which
has
experienced
extensive
human
population
growth.
estimated
potential
risks
99
from
surface
water
sediment
collected
upstream
downstream
major
wastewater
treatment
plant
(WWTP),
nearby
combined
sewer
overflows
(CSO),
adjacent
River.
The
greatest
aquatic
ecosystem
occurred
WWTP
CSO
outfalls,
but
risk
levels
rapidly
dropped
below
thresholds
concern
-
established
by
previous
studies
mainstem.
These
results
suggest
tributaries,
rather
than
larger
rivers,
important
monitor
because
lower
or
intermittent
flow
may
not
adequately
dilute
contaminants
concern.
Common
psychotropics,
as
fluoxetine
venlafaxine,
presented
highest
risks,
with
quotients
often
>
10
1000
sediment,
indicating
need
for
field
studies.
Several
ubiquitous
caffeine
carbamazepine
also
exceeded
throughout
our
study
area
point
specific
neurotoxic
endocrine
action
warrant
investigation.
Since
many
analysis
triggered
concerns
other
areas
around
world,
better
coordination
is
needed
among
programs
improve
global
efforts.
Environmental Management,
Год журнала:
2023,
Номер
71(2), С. 285 - 303
Опубликована: Янв. 13, 2023
This
study
offers
new
insights
into
the
largest
threats
to
natural
and
mixed
World
Heritage
sites
in
developed
countries
as
considered
by
their
management.
In
addition
this,
capacity
of
management
deal
with
is
examined.
An
Ordered
Probit
model
used
that
distinguishes
three
groups
four
categories
adaptive
Data
originate
from
2014
UNESCO
Periodic
Report
II
for
economically
advanced
(Europe,
North
America,
Australia,
New
Zealand,
Japan
South
Korea)
linked
Site
database.
Estimation
results
reveal
probability
a
major
threat
perceived
be
highest
category
climate
change
extreme
weather
events,
followed
local
conditions
affecting
physical
structure
(temperature,
rain,
dust).
Sites
tropical
climates
are
significantly
more
threatened,
those
earlier
listed
danger.
The
likelihood
perceiving
Turkey,
Italy,
Norway
America.
Threats
related
has
lowest
when
other
important
aspects
controlled
for.
Large
areas
have
higher
administrative
than
others.
Bulletin of Environmental Contamination and Toxicology,
Год журнала:
2023,
Номер
112(1)
Опубликована: Дек. 12, 2023
Abstract
Pesticides
enter
non-target
surface
waters
as
a
result
of
agricultural
activities
and
may
reach
water
bodies
in
protected
areas.
We
measured
southwestern
Germany
pesticide
concentrations
after
heavy
rainfalls
streams
drinking
protection
area
near
Hausen
(Freiburg)
the
catchment
Queich
(Landau),
which
originates
from
biosphere
reserve
Palatinate
Forest.
On
average,
32
(n
=
21)
21
10)
pesticides
were
detected
per
sample
event
56)
17),
respectively.
The
majority
>
50%
all
samples
fungicides,
with
fluopyram
being
throughout
samples.
Aquatic
invertebrates
exhibited
highest
risks
16.1%
exceeding
mixture
toxicity
thresholds,
whereas
lower
for
aquatic
plants
(12.9%)
fish
(6.5%).
Mixture
threshold
exceedances
indicate
adverse
ecological
effects
to
occur
at
half
sites
(50%).
This
study
illustrates
presence
mixtures
highlights
organisms
areas
Germany.
