Predictive Value of the Toxcast/Tox21 High Throughput Toxicity Screening Data for Approximating in Vivo Ecotoxicity Endpoints and Ecotoxicological Risk in Eco- Surveillance Applications DOI
Ismael Rodea‐Palomares, Audrey J. Bone

Published: Jan. 1, 2023

Ecotoxicology has long relied on assessing the hazard potential of chemicals through traditional in vivo testing methods to understand possible risk exposure could pose ecological taxa. In past decade, development non-animal new approach (NAMs) for chemical and quickly grown. These are often cheaper faster than toxicity testing, thus amenable high-throughput (HTT), resulting large datasets. The ToxCast/Tox21 HTT programs have produced vitro data thousands covering a space biological activity. relevance these mammalian been much explored. Interest also grown using evaluate environmental exposures taxa importance such as fish, aquatic invertebrates, etc.; particularly purpose estimating from real-world complex mixtures. Understanding relationship relative sensitivity NAMs versus standardized ecotoxicological whole organism models is key component performing reliable read-across data. this work, we explore between ecotoxicity several publicly available databases We performed case studies which compare how different datasets, whether or ToxCast-based, affects conclusions based mixtures derived existing large-scale monitoring Generally, predictive value endpoints (EPs) was poor (r≤0.3). Risk conclusions, including identification drivers prioritized sites, were when vs.

Language: Английский

Suspect, non-target and target screening of pharmaceuticals and personal care products (PPCPs) in a drinking water system DOI
Yuqing Wang, Li‐Xin Hu, Jiahui Zhao

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 808, P. 151866 - 151866

Published: Nov. 23, 2021

Language: Английский

Citations

48
Application of ToxCast/Tox21 data for toxicity mechanism-based evaluation and prioritization of environmental chemicals: Perspective and limitations DOI
Jaeseong Jeong, Donghyeon Kim, Jinhee Choi

et al.

Toxicology in Vitro, Journal Year: 2022, Volume and Issue: 84, P. 105451 - 105451

Published: July 31, 2022

Language: Английский

Citations

37
Trends in the monitoring of legacy and emerging organic pollutants in protected areas DOI
Germán Azcune, Luciana Griffero, Lucía Pareja

et al.

Trends in Environmental Analytical Chemistry, Journal Year: 2022, Volume and Issue: 34, P. e00165 - e00165

Published: May 7, 2022

Language: Английский

Citations

22
Chemical prioritization of pharmaceuticals and personal care products in an urban tributary of the Potomac River DOI Creative Commons
Cheyenne Hawkins, Gregory D. Foster, Scott Glaberman

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 881, P. 163514 - 163514

Published: April 15, 2023

Pharmaceuticals and personal care products (PPCPs) are incredibly diverse in terms of chemical structures, physicochemical properties, modes action, making their environmental impacts challenging to assess. New prioritization methodologies have emerged that compare contaminant monitoring concentrations multiple toxicity data sources, including whole organism high-throughput data, develop a list "high priority" chemicals requiring further study. We applied such an approach assess PPCPs Hunting Creek, urban tributary the Potomac River near Washington, DC, which has experienced extensive human population growth. estimated potential risks 99 from surface water sediment collected upstream downstream major wastewater treatment plant (WWTP), nearby combined sewer overflows (CSO), adjacent River. The greatest aquatic ecosystem occurred WWTP CSO outfalls, but risk levels rapidly dropped below thresholds concern - established by previous studies mainstem. These results suggest tributaries, rather than larger rivers, important monitor because lower or intermittent flow may not adequately dilute contaminants concern. Common psychotropics, as fluoxetine venlafaxine, presented highest risks, with quotients often > 10 1000 sediment, indicating need for field studies. Several ubiquitous caffeine carbamazepine also exceeded throughout our study area point specific neurotoxic endocrine action warrant investigation. Since many analysis triggered concerns other areas around world, better coordination is needed among programs improve global efforts.

Language: Английский

Citations

11
Predictive value of the ToxCast/Tox21 high throughput toxicity screening data for approximating in vivo ecotoxicity endpoints and ecotoxicological risk in eco- surveillance applications DOI
Ismael Rodea‐Palomares, Audrey J. Bone

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 914, P. 169783 - 169783

Published: Jan. 4, 2024

Language: Английский

Citations

4
Pesticide occurrence in protected surface waters in nature conservation areas of Germany DOI
Jakob Wolfram,

Sascha Bub,

Lara L. Petschick

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 858, P. 160074 - 160074

Published: Nov. 9, 2022

Language: Английский

Citations

17
Pharmaceutical Pollution of the English National Parks DOI Creative Commons
Alistair B.A. Boxall,

Rob Collins,

John L. Wilkinson

et al.

Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(11), P. 2422 - 2435

Published: Aug. 14, 2024

England's 10 national parks are renowned for their landscapes, wildlife, and recreational value. However, surface waters in the may be vulnerable to pollution from human-use chemicals, such as active pharmaceutical ingredients (APIs), because of factors like ineffective wastewater treatment, seasonal tourism, a high proportion elderly residents, presence low-flow water bodies that limit dilution. The present study determined extent API contamination English by monitoring 54 APIs 37 rivers across all over two seasons. Results were compared existing data sets UK cities concentration thresholds ecological impacts antimicrobial resistance selection. revealed widespread parks, with detected at 52 out sites both Thirty-one detected, metformin, caffeine, paracetamol showing highest mean concentrations cetirizine, fexofenadine being most frequently detected. While total generally lower than seen previously cities, locations Peak District Exmoor had higher city rivers. Fourteen either amitriptyline, carbamazepine, clarithromycin, diltiazem, paracetamol, or propranolol above levels concern fish, invertebrates, algae selection resistance. Therefore, appears pose risks health potentially human through use. Given these biodiversity hotspots protected ecosystems, there is an urgent need improved management more not only England but also similar environments world. Environ Toxicol Chem 2024;43:2422-2435. © 2024 Author(s). Environmental Toxicology Chemistry published Wiley Periodicals LLC on behalf SETAC.

Language: Английский

Citations

3
Threat Perception and Adaptive Capacity of Natural World Heritage Site Management DOI Creative Commons
Martin Falk, Eva Hagsten

Environmental Management, Journal Year: 2023, Volume and Issue: 71(2), P. 285 - 303

Published: Jan. 13, 2023

This study offers new insights into the largest threats to natural and mixed World Heritage sites in developed countries as considered by their management. In addition this, capacity of management deal with is examined. An Ordered Probit model used that distinguishes three groups four categories adaptive Data originate from 2014 UNESCO Periodic Report II for economically advanced (Europe, North America, Australia, New Zealand, Japan South Korea) linked Site database. Estimation results reveal probability a major threat perceived be highest category climate change extreme weather events, followed local conditions affecting physical structure (temperature, rain, dust). Sites tropical climates are significantly more threatened, those earlier listed danger. The likelihood perceiving Turkey, Italy, Norway America. Threats related has lowest when other important aspects controlled for. Large areas have higher administrative than others.

Language: Английский

Citations

9
Levels and ecological risk of selected organic pollutants in the high-altitude alpine cryosphere - The Adamello-Brenta Natural Park (Italy) as a case study DOI Creative Commons
C. Rizzi, Sara Villa, Luca Rossini

et al.

Environmental Advances, Journal Year: 2022, Volume and Issue: 7, P. 100178 - 100178

Published: Jan. 22, 2022

Language: Английский

Citations

12
Pesticide Mixtures in Surface Waters of Two Protected Areas in Southwestern Germany DOI Creative Commons
Anna Schemmer, Jakob Wolfram, Alexis P. Roodt

et al.

Bulletin of Environmental Contamination and Toxicology, Journal Year: 2023, Volume and Issue: 112(1)

Published: Dec. 12, 2023

Abstract Pesticides enter non-target surface waters as a result of agricultural activities and may reach water bodies in protected areas. We measured southwestern Germany pesticide concentrations after heavy rainfalls streams drinking protection area near Hausen (Freiburg) the catchment Queich (Landau), which originates from biosphere reserve Palatinate Forest. On average, 32 (n = 21) 21 10) pesticides were detected per sample event 56) 17), respectively. The majority > 50% all samples fungicides, with fluopyram being throughout samples. Aquatic invertebrates exhibited highest risks 16.1% exceeding mixture toxicity thresholds, whereas lower for aquatic plants (12.9%) fish (6.5%). Mixture threshold exceedances indicate adverse ecological effects to occur at half sites (50%). This study illustrates presence mixtures highlights organisms areas Germany.

Language: Английский

Citations

4