Journal of Proteome Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Deltamethrin
(DM)
is
a
widely
used
pyrethroid
pesticide
associated
with
childhood
neurodevelopmental
disorders.
However,
the
specific
impact
of
DM
exposure
during
distinct
early
life
stages
remains
unclear.
Here,
zebrafish
embryos
were
exposed
to
at
different
stages:
before
(10-16
hpf),
onset
(16-24
peak
(24-36
hpf)
hypothalamic
neurogenesis,
and
continuously
from
10
120
hpf
(subchronic
exposure),
using
dosages
(1,
100,
250
nM).
Exposure
middle/high-dose
24-36
10-120
significantly
reduced
locomotor
activities
increased
apoptotic
cells
in
spinal
cord.
As
pivotal
factor
central
nervous
system
disorder
progression,
altered
lipid
metabolism
was
investigated
nontargeted
lipidomic
analysis.
10-16
led
most
significant
lipidome
reprogramming.
Despite
exhibiting
dose-dependent
trend,
even
low-dose
changed
lipidome.
Cer
40:2;2
PG
44:12
showed
potential
identifying
effects.
Significant
changes
sphingolipid,
cardiolipin,
phosphatidylglycerol,
glycerolipid
pathways
linked
DM-induced
developmental
neurotoxicity,
indicating
impaired
membrane
function,
mitochondrial
damage,
disrupted
energy
metabolism.
Our
study
sheds
new
light
on
assessing
disturbances
intervention
targets,
emphasizing
sensitivity
critical
phase
neurodevelopment.
PLoS ONE,
Год журнала:
2025,
Номер
20(5), С. e0324355 - e0324355
Опубликована: Май 23, 2025
The
presence
of
UV-360,
a
commonly
utilized
benzotriazole
ultraviolet
stabilizer,
has
been
frequently
detected
in
diverse
environments
and
organisms.
However,
existing
knowledge
regarding
the
potential
impacts
UV-360
exposure
on
organisms
remains
limited.
To
evaluate
influence
zebrafish
during
their
initial
developmental
phases.
study
began
with
an
assessment
impact
larval
stages.
Subsequently,
investigation
focused
examining
its
effects
locomotor
behaviors.
Additionally,
analyses
were
conducted
neuronal
development,
expression
genes
associated
neurotoxicity,
electrophysiological
recordings.
Finally,
research
extended
to
exploration
transcriptome-level
gene
profiles.
Exposure
exhibited
significant
adverse
larvae,
evidenced
by
marked
reduction
hatching
rate,
decreased
heart
impaired
development
total
body
length.
Furthermore,
induced
notable
behavioral
alterations,
malformations
spinal
motor
neuron
axons,
substantial
decrease
both
area
volume
these
axons.
neurotoxicity-related
spike
activity
significantly
altered
exposure.
Lastly,
triggered
modifications
transcriptomic
profile
considerable
proportion
differentially
expressed
signal
transduction
processes
neuroactive
ligand-receptor
interaction
pathway.
results
this
revealed
dose-dependent
neurobehavioral
toxicity
larvae.
observed
ligand-receptors
disruptions
neurotransmitter
systems
suggested
mechanism
for
neurotoxicity
These
findings
contribute
understanding
toxicological
larvae
provide
strong
evidence
help
clarify
mechanisms
UV-360-induced
toxicity.
