Effects of tefluthrin exposure on early life stages in zebrafish: Insights into cardiac and skeletal development, oxidative stress and apoptosis

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117931 - 117931

Published: Feb. 19, 2025

Language: Английский

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Lipidomics Atlas Tracks Alterations Associated with Deltamethrin-Induced Developmental Neurotoxicity in Embryonic Zebrafish

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Deltamethrin (DM) is a widely used pyrethroid pesticide associated with childhood neurodevelopmental disorders. However, the specific impact of DM exposure during distinct early life stages remains unclear. Here, zebrafish embryos were exposed to at different stages: before (10-16 hpf), onset (16-24 peak (24-36 hpf) hypothalamic neurogenesis, and continuously from 10 120 hpf (subchronic exposure), using dosages (1, 100, 250 nM). Exposure middle/high-dose 24-36 10-120 significantly reduced locomotor activities increased apoptotic cells in spinal cord. As pivotal factor central nervous system disorder progression, altered lipid metabolism was investigated nontargeted lipidomic analysis. 10-16 led most significant lipidome reprogramming. Despite exhibiting dose-dependent trend, even low-dose changed lipidome. Cer 40:2;2 PG 44:12 showed potential identifying effects. Significant changes sphingolipid, cardiolipin, phosphatidylglycerol, glycerolipid pathways linked DM-induced developmental neurotoxicity, indicating impaired membrane function, mitochondrial damage, disrupted energy metabolism. Our study sheds new light on assessing disturbances intervention targets, emphasizing sensitivity critical phase neurodevelopment.

Language: Английский

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Acute Toxicity, Bioaccumulation and Elimination Rate of Deltamethrin and Cypermethrin in Crucian Carp (Carassius auratus)

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 388 - 388

Published: April 9, 2025

Pyrethroid pesticides like deltamethrin and cypermethrin are widely used in aquaculture, yet their food safety implications remain understudied. This research investigated acute toxicity, tissue-specific bioaccumulation, elimination patterns crucian carp (Carassius auratus). Acute toxicity tests determined 96 h LC50 values of 9.68~11.22 ng·mL⁻1 (deltamethrin) 3.12~5.01 (cypermethrin) with 95% confidence intervals. During 8-day exposures to sublethal concentrations (1/10 1/100 LC50), accumulated predominantly the liver (peak: 21.98 ng·g⁻1 at 1.04 ng·mL⁻1, standard deviation is 0.064 ng·mL⁻1), whereas concentrated muscle 9.76 0.40 0.138 ng·mL⁻1). A 7-day phase revealed faster clearance low-concentration residues, >50% removal within 24 all tissues. Bioconcentration factors were highest (36.62 for deltamethrin) (45.17 cypermethrin). These results highlight accumulation risks rapid initial elimination, providing critical data optimize pesticide-dosing protocols, mitigate ecotoxicological threats, enhance aquaculture systems.

Language: Английский

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The impacts of pesticide exposure on fish conspecific interactions: A systematic review and meta-analysis

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126353 - 126353

Published: May 1, 2025

Language: Английский

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Effects of lipophilic phycotoxin okadaic acid on the early development and transcriptional expression of marine medaka Oryzias melastigma

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 260, P. 106576 - 106576

Published: May 15, 2023

Language: Английский

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Fenpropathrin causes alterations in locomotion and social behaviors in zebrafish (Danio rerio)

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 265, P. 106756 - 106756

Published: Nov. 7, 2023

Language: Английский

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Combined effects of abamectin and temperature on the physiology and behavior of male lizards (Eremias argus): Clarifying adaptation and maladaptation

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 837, P. 155794 - 155794

Published: May 10, 2022

Language: Английский

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Antioxidant/protective effects of carob pod (Ceratonia siliqua L.) water extract against deltamethrin-induced oxidative stress/toxicity in zebrafish larvae

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2023, Volume and Issue: 267, P. 109584 - 109584

Published: Feb. 22, 2023

Language: Английский

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Low-frequency noise impairs righting reflex behavior by disrupting central nervous system in the sea slug Onchidium reevesii

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170552 - 170552

Published: Feb. 1, 2024

Language: Английский

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Assessment of deltamethrin-induced DNA damage, neurotoxic and neuroimmune effects in the brain tissue of brown trout (Salmo trutta fario)

Veterinární Medicína, Journal Year: 2024, Volume and Issue: 69(3), P. 77 - 83

Published: March 28, 2024

This study investigated the impact of deltamethrin (DM) toxicity on brown trout (Salmo trutta fario), examining its effects immune system, including white blood cell (WBC), lymphocyte (Lym), total immunoglobulin (T. Ig), and lysozyme levels, as well neurotoxic consequences brain tissue. The encompassed oxidative stress, activity antioxidant enzymes, such superoxide dismutase (SOD) catalase (CAT), acetylcholinesterase (AChE) activity, DNA damage using 8-hydroxy-2-deoxyguanosine (8-OHdG). DM exposure led to elevated levels malondialdehyde (MDA), 8-OHdG, while concurrently causing a reduction in AChE protein lipid content, WBC count, Lym, T. Ig SOD CAT tissues groups 2 3 when compared those group 1. In summary, findings this strongly indicate that induces damage, immunotoxicity, neurotoxicity tissue trout, primarily due excessive production reactive oxygen species (ROS). Moreover, observed dose-dependent responses environmental concentrations all parameters suggest potential utility aquaculture risk assessment.

Language: Английский

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