Journal of Applied Toxicology,
Год журнала:
2023,
Номер
44(1), С. 66 - 85
Опубликована: Июнь 29, 2023
Abstract
Microplastics
(MPs)
and
nanoplastics
(NPs)
are
extensively
distributed
in
the
environment.
However,
a
comprehensive
review
in‐depth
discussion
on
effects
of
MPs
NPs
to
reproductive
capacity
transgenerational
toxicity
mammals,
especially
humans,
is
lacked.
It
suggested
that
microplastics
could
accumulate
mammalian
organs
exert
toxic
system
for
both
sexes.
For
males,
damage
consists
abnormal
testicular
sperm
structure,
decreased
vitality,
endocrine
disruption,
which
were
caused
by
oxidative
stress,
inflammation,
apoptosis
cells,
autophagy,
cytoskeleton,
hypothalamic‐pituitary‐testicular
axis.
females,
includes
ovary
uterus
structure
granulosa
cell
apoptosis,
hypothalamic‐pituitary‐ovary
axis
abnormalities,
tissue
fibrosis.
toxicity,
premature
mortality
existed
rodent
offspring
after
maternal
exposure
microplastics.
Among
surviving
offspring,
metabolic
disorders,
dysfunction,
immune,
neurodevelopmental,
cognitive
disorders
detected,
these
events
directly
correlated
with
translocation
NPs.
Studies
human‐derived
cells
or
organoids
demonstrated
studies
sexes
yet
phase
exploring
suitable
experimental
models,
more
detailed
research
threat
human
fertility
still
urgently
needed.
Further
will
help
assess
public
health
risks.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
277, С. 116357 - 116357
Опубликована: Апрель 26, 2024
Polystyrene
microplastics
(PS-MPs)
are
new
types
of
environmental
pollutant
that
have
garnered
significant
attention
in
recent
years
since
they
were
found
to
cause
damage
the
human
respiratory
system
when
inhaled.
The
pulmonary
fibrosis
is
one
serious
consequences
PS-MPs
inhalation.
However,
impact
and
underlying
mechanisms
on
not
clear.
In
this
study,
we
studied
potential
lung
toxicity
PS-MPs-developed
by
long-term
intranasal
inhalation
PS-MPs.
results
showed
after
exposing
PS-MPs,
lungs
model
mouse
had
different
levels
fibrosis.
Meanwhile,
resulted
a
markedly
decrease
glutathione
(GSH),
an
increase
malondialdehyde
(MDA),
iron
overload
tissue
mice
alveolar
epithelial
cells
(AECs).
These
findings
suggested
occurrence
PS-MP-induced
ferroptosis.
Inhibitor
ferroptosis
(Fer-1)
alleviated
PS-MPs-induced
Mechanically,
triggered
cell
promoted
development
via
activating
cGAS/STING
signaling
pathway.
Inhibition
with
G150/H151
attenuated
exposure.
Together,
these
data
provided
novel
mechanistic
insights
therapeutic
paradigm.
Environmental Toxicology,
Год журнала:
2022,
Номер
37(10), С. 2552 - 2565
Опубликована: Июль 14, 2022
Plastics
are
novel
environmental
pollutants
with
potential
threats
to
the
ecosystem.
At
least
5.25
trillion
plastic
particles
in
environment,
of
which
nanoplastics
<100
nm
diameter.
Polystyrene
(PS-NPs)
exposure
damaged
spleen's
immune
function.
Lipopolysaccharide
(LPS)
induced
other
toxicants
damage
cells
and
organs,
triggering
inflammation.
However,
mechanism
PS-NPs
aggravated
LPS-induced
spleen
injury
remains
unclear.
In
this
study,
or/and
LPS
mice
model
was
replicated
by
intraperitoneal
injection
LPS,
were
exposed
RAW264.7
cells.
The
histopathological
ultrastructural
changes
observed
H&E
staining
transmission
electron
microscope.
Western
Blot,
qRT-PCR,
fluorescent
probes
used
detect
reactive
oxygen
species
(ROS),
oxidative
stress
indicators,
inflammatory
factors,
necroptosis-related
indicators
results
showed
that
or
stress,
activated
MAPK
pathway,
eventually
caused
necroptosis
inflammation
Compared
single
treatment
group,
+
group
more
obvious.
Furthermore,
ROS
inhibitor
N-Acetyl-L-cysteine
(NAC)
significantly
inhibited
activation
mitogen-activated
protein
kinase
(MAPK)
signaling
pathway
co-treatment
reducing
demonstrated
promoted
through
ROS/MAPK
pathway.
This
study
increases
data
on
organism
expands
research
ideas
clues.
Frontiers in Toxicology,
Год журнала:
2022,
Номер
4
Опубликована: Авг. 31, 2022
Microplastics
(MPs),
small
pieces
of
plastic
(∼5
mm),
are
released
into
the
environment
not
only
as
a
result
decomposition
large-sized
plastics
but
also
from
day-to-day
use
products.
Chronic
exposure
to
MPs
has
been
attributed
harmful
effects
on
aquatic
organisms
and
rodents.
Effects
include
gastrointestinal
toxicity,
hepatotoxicity,
neurotoxicity,
reproductive
developmental
toxicities.
Exposure
may
potentially
affect
human
health.
Herein,
we
reviewed
impact
male
female
systems
associated
mechanisms
involved
in
toxicities
MPs.
We
performed
literature
search
Google
Scholar
PubMed
using
following
keywords:
toxicity;
studies;
infertility;
aquatics;
Evidence
accumulation
reported
many
organs
humans
experimental
models.
The
have
manifested
mammalian
animals,
including
gametes,
embryos,
their
offspring.
This
review
describes
various
signaling
pathways
MPs-associated
