The Science of The Total Environment, Год журнала: 2025, Номер 968, С. 178882 - 178882
Опубликована: Фев. 22, 2025
Язык: Английский
The Science of The Total Environment, Год журнала: 2023, Номер 895, С. 165076 - 165076
Опубликована: Июнь 28, 2023
Язык: Английский
Процитировано
153
Journal of Hazardous Materials, Год журнала: 2023, Номер 450, С. 131090 - 131090
Опубликована: Фев. 26, 2023
As biota are increasingly exposed to plastic pollution, there is a need closely examine the sub-lethal 'hidden' impacts of ingestion. This emerging field study has been limited model species in controlled laboratory settings, with little data available for wild, free-living organisms. Highly impacted by ingestion, Flesh-footed Shearwaters (Ardenna carneipes) thus an apt these environmentally relevant manner. A Masson's Trichrome stain was used document any evidence plastic-induced fibrosis, using collagen as marker scar tissue formation proventriculus (stomach) 30 Shearwater fledglings from Lord Howe Island, Australia. Plastic presence highly associated widespread and extensive changes to, even loss of, structure within mucosa submucosa. Additionally, despite naturally occurring indigestible items, such pumice, also being found gastrointestinal tract, this did not cause similar scarring. highlights unique pathological properties plastics raises concerns other Further, extent severity fibrosis documented gives support novel, fibrotic disease, which we define 'Plasticosis,'.
Язык: Английский
Процитировано
108
Environment International, Год журнала: 2023, Номер 179, С. 108171 - 108171
Опубликована: Авг. 25, 2023
Microplastic particles (MP) are prevalent in both industrial production and the natural environment, posing a significant concern for human health. Daily diet, air inhalation, skin contact major routines of MP intake human. The main injury target systems MPs include digestive system, respiratory cardiovascular system. However, study on MPs' adverse effects heart is less than other organs. Previous vivo studies have demonstrated that can induce injuries, including abnormal rate, apoptosis cardiomyocytes, mitochondrial membrane potential change, fibrin overexpression. To address animal welfare concerns overcome inter-species variations, this employed pluripotent stem cell-derived vitro three-dimensional cardiac organoid (CO) model to investigate heart. distinct cavities COs allowed observation aggregation spatial distribution following polystyrene-MP (PS) exposure dynamic After various concentrations PS (0.025, 0.25 2.5 µg/mL, with lowest concentration equivalent internal levels), exhibited increased oxidative stress, inflammatory response, apoptosis, collagen accumulation. These findings were consistent observations, terms increases interventricular septal thickness. expression hypertrophic-related genes (MYH7B/ANP/BNP/COL1A1) changed noticeably cardiac-specific markers MYL2/MYL4/CX43 also markedly elevated. Our revealed could induced hypertrophy vitro, indicating may be an under-recognized risk factor
Язык: Английский
Процитировано
53
The Science of The Total Environment, Год журнала: 2024, Номер 942, С. 173770 - 173770
Опубликована: Июнь 7, 2024
Язык: Английский
Процитировано
17
Fish & Shellfish Immunology, Год журнала: 2022, Номер 131, С. 1075 - 1084
Опубликована: Ноя. 14, 2022
Язык: Английский
Процитировано
53
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Май 10, 2024
Background Polystyrene microplastics (PS-MPs) exhibit multi-target, multi-dimensional, chronic, and low toxicity to the cardiovascular system. They enter bloodstream through gastrointestinal tract respiratory system, altering blood parameters conditions, inducing thrombotic diseases, damaging myocardial tissue promotion of oxidative stress inflammatory responses in cells. However, many links mechanisms remain unclear. Methods In this study, 48 wistar rats were randomly divided into four groups exposed different concentrations PS-MPs: control group (0 mg/kg/d), dose (0.5 middle (5 mg/kg/d) high (50 with 12 each group. After 90 consecutive days intragastric administration PS-MPs, biochemical markers myocardium, aorta detected, HE staining was performed observe toxic effects PS-mps on Furthermore, non-targeted metabolomics methods used analyze effect PS-MPs exposure metabolism system rats, explore its potential molecular mechanism. Results The results revealed no pathological changes heart following exposure. enzyme levels showed a significant increase. Moreover, polystyrene caused disorder lipid led an increase indicators inflammation aortic tissues, but resulted decrease level IL-6. Untargeted that metabolites antioxidant anti-inflammatory effects, including equol 4-hydroxybenzoic acid, significantly upregulated. Conclusion These suggest long-term may lead abnormal damage. mechanism be related response. Exogenous antioxidants own have protective injury. Therefore, understanding toxicological not only helps elucidate pathogenesis, also provides new ideas for treatment chronic diseases.
Язык: Английский
Процитировано
15
Environmental Chemistry Letters, Год журнала: 2024, Номер 22(6), С. 2913 - 2941
Опубликована: Авг. 20, 2024
Язык: Английский
Процитировано
14
Cambridge Prisms Plastics, Год журнала: 2024, Номер 2
Опубликована: Янв. 1, 2024
Abstract Mitochondria are unique organelles to perform critical functions such as energy production, lipid oxidation, calcium homeostasis, and steroid hormone synthesis in eukaryotic cells. The proper functioning of mitochondria is crucial for cellular survival, bioenergetics. Mitochondrial structure function maintained by the mitochondrial quality control system, which consists processes biogenesis, dynamics (fusion/fission), mitophagy, unfolded protein response UPR MT . dysfunction and/or damage associated with initiation progression several human diseases, including neurodegenerative, cardiovascular, age-related diabetes, cancer. Environmental stress contaminants may exacerbate sensitivity causes dysfunction. There growing evidence about impact nanoplastics (NPs) microplastics (MPs) on health function. MPs/NPs were reported trigger oxidative reactive oxygen species eventually change membrane potential. can cross through biological barriers body be internalized cells, potentially altering dynamics, bioenergetics, signaling pathways, thus impacting metabolism This review states effects homeostasis well apoptosis discussed.
Язык: Английский
Процитировано
12
Journal of Environmental Sciences, Год журнала: 2024, Номер 151, С. 200 - 210
Опубликована: Март 19, 2024
Язык: Английский
Процитировано
10
Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)
Опубликована: Апрель 17, 2024
Abstract Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as defense response becomes particularly evident upon exposure nanomaterials (NMs), especially environmental nanoparticles (NPs) nanoplastics (nPs). This has positioned modulation at the forefront nanotechnology-based therapeutic interventions. While NMs can exploit enhance outcomes, they also trigger it pro-survival against NP-induced toxicity. Conversely, heightened may lead regulated cell death (RCD), in particular autophagic death, NP exposure. Thus, relationship between exhibits dual nature with Recognizing decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. review delves into present-day potential autophagy-modulating NMs, shedding light on their status clinical trials, intervention applications discusses potency application early indicator NM Graphical
Язык: Английский
Процитировано
10