The uses of zebrafish (Danio rerio) as an in vivo model for toxicological studies: A review based on bibliometrics

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 272, С. 116023 - 116023

Опубликована: Янв. 30, 2024

An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) toxicology based on bibliometrics. Totally 56,816 publications about from 2002 to 2023 were found Web Science Core Collection, with Toxicology as top 6 among all disciplines. Accordingly, bibliometric map reveals that "toxicity" has become a hot keyword. It further most common exposure types include acute, chronic, and combined exposure. The toxicological effects behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, reproductive transgenerational toxicity. mechanisms oxidative stress, inflammation, autophagy, dysbiosis gut microbiota. toxicants commonly evaluated by using nanomaterials, arsenic, metals, bisphenol, dioxin. Overall, provide unique well-accepted investigate mechanisms. We also discussed possible ways address some limitations model, such combination human organoids avoid species differences.

Язык: Английский

---

Polystyrene microplastics effects on zebrafish embryological development: Comparison of two different sizes

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 106, С. 104371 - 104371

Опубликована: Янв. 20, 2024

Microplastics have become a great worldwide problem and it's therefore important to study their possible effects on human environmental health. In this study, zebrafish embryos were used compare two different sizes of polystyrene microplastics (PS-MPs), 1 μm 3 respectively, at 0.01, 0.1, 1.0 10.0 mgL-1, monitored up 72 hours. Toxicity tests demonstrated that neither the PS-MPs altered embryos' survival normal hatching process. Instead, higher concentrations both caused an increase heart rate phenotypic changes. The entered accumulated in larvae concentration mgL-1 same apoptotic processes correlated redox homeostasis reported results give realistic view negative exposure provide new information toxicity, also considering sizes.

Язык: Английский

---

Immunotoxicity of microplastics: Carrying pathogens and destroying the immune system

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 177, С. 117817 - 117817

Опубликована: Июнь 13, 2024

Язык: Английский

---

Exploring the Combined Effect of Exercise and Apigenin on Aluminium-Induced Neurotoxicity in Zebrafish

Molecular Neurobiology, Год журнала: 2024, Номер 61(8), С. 5320 - 5336

Опубликована: Янв. 8, 2024

Язык: Английский

---

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(9), С. 1011 - 1017

Опубликована: Март 5, 2024

With continuous population and economic growth in the 21

Язык: Английский

---

Toxic effects of environmental-relevant exposure to polyethylene terephthalate (PET) micro and nanoparticles in zebrafish early development

NanoImpact, Год журнала: 2024, Номер 33, С. 100497 - 100497

Опубликована: Янв. 1, 2024

Язык: Английский

---

Biological exposure to microplastics and nanoplastics and plastic additives: impairment of glycolipid metabolism and adverse effects on metabolic diseases

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(51), С. 60778 - 60791

Опубликована: Окт. 16, 2024

Язык: Английский

---

Toxic effects of polystyrene nanoplastics on MDA-MB-231 breast cancer and HFF-2 normal fibroblast cells: viability, cell death, cell cycle and antioxidant enzyme activity

Environmental Sciences Europe, Год журнала: 2025, Номер 37(1)

Опубликована: Янв. 2, 2025

Environmental nanoplastics pose a potential health risk due to human exposure, necessitating studies on their cellular effects. This study aims assess the toxic and antibacterial properties of polystyrene (PS-NH2) MDA-MB-231 breast cancer cells HFF-2 fibroblast cells, while also evaluating oxidative stress responses. Additionally, explores anti-tumor effects apoptosis induction by PS-NH2. The primary objectives were determine cytotoxicity, efficacy, response PS-NH2 at different concentrations sizes. aimed investigate mechanism cell death, including apoptosis, necrosis, cycle arrest, changes in antioxidant enzyme activity (SOD GPx). Nanoplastic characterized using FTIR, FESEM, zeta analysis. Antibacterial assessed agar dilution method, MTT assay determined cytotoxicity cells. Apoptosis, activities (SOD, GPx) evaluated. FTIR analysis confirmed amino-functionalization with wide peak 3386 cm-1, indicated neutral charge. showed no against E. coli or Staphylococcus aureus sizes 90, 200, 300 nm. Cytotoxicity assays revealed dose-dependent decreases viability for both lines. SOD GPx decreased significantly increasing concentrations. Both lines underwent accumulation G1 sub-G1 phases, indicating apoptotic death. exhibits dose- size-dependent Smaller particle higher enhance stress, leading arrest.

Язык: Английский

---

Unseen Toxins: Exploring the Human Health Consequences of Micro and Nanoplastics

Toxicology Reports, Год журнала: 2025, Номер 14, С. 101955 - 101955

Опубликована: Фев. 15, 2025

Язык: Английский

---

3-D models for studying microplastics effects on humans

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 417 - 441

Опубликована: Янв. 1, 2025

Язык: Английский

---