International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113180 - 113180
Опубликована: Сен. 20, 2024
Язык: Английский
Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 205, С. 106153 - 106153
Опубликована: Сен. 25, 2024
Язык: Английский
Процитировано
17
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 278, С. 116410 - 116410
Опубликована: Май 1, 2024
Environmental exposure to endocrine disruptors, such as pesticides, could contribute a decline of human fertility. Glyphosate (GLY) is the main component Based Herbicides (GBHs), which are most commonly herbicides used in world. Various animal model studies demonstrated its reprotoxicity. In Europe, GLY authorization agriculture has been extended until 2034. Meanwhile toxicity humans still debate. The aims our study were firstly analyse concentration and metabolite, amino-methyl-phosphonic acid (AMPA) by LC/MS-MS seminal blood plasma an infertile French men population (n=128). We secondly determined Total Antioxidant Status (TAS) Oxidant (TOS) using commercial colorimetric kits some oxidative stress biomarkers including malondialdehyde (MDA) 8-hydroxy-2′-deoxyguanosine (8-OHdG) ELISA assays. next analysed potential correlations between sperm parameters (sperm concentration, progressive speed, anormal forms). Here, we detected for first time significant proportions showed that was four times higher than those observed plasma. At opposite, AMPA undetectable. also strong positive correlation concentrations 8-OHdG concentrations, latter reflecting DNA impact. addition, TOS, Oxidative Stress Index (OSI) (TOS/TAS), MDA significantly with glyphosate plasma, respectively. Taken together, results suggest negative impact on reproductive health possibly his progeny. A precaution principle should be applied at actual discussion GBHs formulants uses Europe authorities.
Язык: Английский
Процитировано
11
Journal of Advanced Research, Год журнала: 2024, Номер unknown
Опубликована: Май 1, 2024
Phthalates exposure is a major public health concern due to the accumulation in environment and associated with levels of testosterone reduction, leading adverse pregnancy outcomes. However, relationship between phthalate-induced level decline ferroptosis remains poorly defined.
Язык: Английский
Процитировано
9
Free Radical Research, Год журнала: 2025, Номер unknown, С. 1 - 17
Опубликована: Март 25, 2025
The biological effects of edaravone (Eda), a free radical scavenger, include anti-inflammatory, antioxidant, and neuroprotective qualities. Nevertheless, the function potential mechanisms Eda in central nervous system injury damage are still unknown. A rat model acute diquat toxicity was constructed to observe pathological changes brain tissues after administration. mitophagy ferroptosis PC12 cells were assessed protective activity Eda. To assess methylation levels m6A RNA, EpiQuik RNA Methylation Quantification Kit utilized. RIP, dual luciferase reporter assay mRNA stability detection confirm relationship between METTL14 Aldh11l1. Knockdown overexpression experiments performed determine Aldh1l1 on rats stimulated with under treatment. dramatically ameliorated diquat-induced injury. notably attenuated apoptosis, pro-inflammatory cytokines activation, oxidative stress rats. significantly suppressed diquat-stimulated cells. Mitophagy inhibitor Mdivi-1 reversed induction via decreased Fe2+ content increased Ca2+ level. knockdown therapeutic effect promoted METTL14-mediated alleviates induced by vivo vitro. has injury, its mechanism may be related activation modification Aldh11l1 inhibition ferroptosis.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 28, 2025
Glyphosate (GLY) is a well-known herbicide with significant applications in both agriculture and non-agriculture. However, GLY overuse recent years has resulted detection of residues many crops, endangering human health food safety. Our aim to investigate the relationship between urinary mortality, as well its influencing factors. The National Health Nutrition Examination Survey (NHANES) data from 4740 American adults were examined. Fitted smooth curves, generalized summation models, multiple logistic regression models used mortality. To potential regulatory elements two effects, perform subgroup analysis. During median follow-up 4.03 years, there total 238 all-cause deaths, 75 cardiovascular disease (CVD) deaths 52 cancer deaths. positively correlated Each 1 ng/ml increase was associated 40% increased risk mortality (Hazard ratio (HR) 1.40, 95% confidence interval (CI) 1.09-1.80), an 50% High group compared Low (HR 1.50, CI 1.05-2.14). In analysis, association significantly modified by gender (P for interaction = 0.03), hypertension 0.022). Higher seems be more death, may affect this association. Furthermore, urine have higher effect on people without hypertension.
Язык: Английский
Процитировано
0
Reproductive Toxicology, Год журнала: 2024, Номер 126, С. 108604 - 108604
Опубликована: Май 2, 2024
Язык: Английский
Процитировано
3
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116962 - 116962
Опубликована: Авг. 28, 2024
Glyphosate and glyphosate-based herbicides (GBH), widely used globally, were initially considered harmless to humans. Experimental studies have suggested that these substances can disrupt iron homeostasis by interfering with uptake or triggering inflammatory responses. However, their potential impact on human remains underexplored.
Язык: Английский
Процитировано
1
Environmental Pollution, Год журнала: 2024, Номер 363, С. 125118 - 125118
Опубликована: Окт. 14, 2024
Язык: Английский
Процитировано
1
The Science of The Total Environment, Год журнала: 2024, Номер 951, С. 175606 - 175606
Опубликована: Авг. 17, 2024
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113180 - 113180
Опубликована: Сен. 20, 2024
Язык: Английский
Процитировано
0