Current Overview of Metal Nanoparticles’ Synthesis, Characterization, and Biomedical Applications, with a Focus on Silver and Gold Nanoparticles

Pharmaceuticals, Год журнала: 2023, Номер 16(10), С. 1410 - 1410

Опубликована: Окт. 4, 2023

Metal nanoparticles (NPs) have garnered considerable attention, due to their unique physicochemical properties, that render them promising candidates for various applications in medicine and industry. This article offers a comprehensive overview of the most recent advancements manufacturing, characterization, biomedical utilization metal NPs, with primary focus on silver gold NPs. Their potential as effective anticancer, anti-inflammatory, antimicrobial agents, drug delivery systems, imaging agents diagnosis treatment variety disorders is reviewed. Moreover, translation therapeutic settings, issue inclusion clinical trials, are assessed light over 30 investigations concentrate administering either or NPs conditions ranging from nosocomial infections different types cancers. paper aims not only examine biocompatibility nanomaterials but also emphasize challenges may limit safe integration into healthcare practices. More than 100 nanomedicines currently market, which justifies ongoing study use medicine. Overall, present review highlight innovative therapeutics field biomedicine, citing some relevant current applications.

Язык: Английский

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Polysialic acid-based nanoparticles for enhanced targeting and controlled dexamethasone release in pulmonary inflammation treatment

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139550 - 139550

Опубликована: Янв. 1, 2025

Язык: Английский

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Polymeric nanoparticles-siRNA as an emerging nano-polyplexes against ovarian cancer

Colloids and Surfaces B Biointerfaces, Год журнала: 2022, Номер 218, С. 112766 - 112766

Опубликована: Авг. 9, 2022

Язык: Английский

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Dendrimers as prospective nanocarrier for targeted delivery against lung cancer

European Polymer Journal, Год журнала: 2022, Номер 180, С. 111635 - 111635

Опубликована: Окт. 13, 2022

Язык: Английский

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Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 3187 - 3215

Опубликована: Апрель 1, 2024

Abstract: Green synthesis of silver (Ag) and gold (Au) nanoparticles (NPs) has acquired huge popularity owing to their potential applications in various fields. A large number research articles exist the literature describing green Ag Au NPs for biomedical applications. However, these findings are scattered, making it time-consuming researchers locate promising advancements unexplored Unlike other review articles, this systematic study not only highlights recent but also explores The article discusses approaches highlighting emerging developments novel strategies. Then, reviews important synthesized by critically evaluating expected advantages. To expose future direction field, describes NPs. Finally, discuss challenges limitations This will serve as a valuable reference researchers, working on Keywords: nanoparticles, environmental-friendly, applications, potentials

Язык: Английский

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Anticancer Potential of Antimicrobial Peptides: Focus on Buforins

Polymers, Год журнала: 2024, Номер 16(6), С. 728 - 728

Опубликована: Март 7, 2024

In seeking alternative cancer treatments, antimicrobial peptides (AMPs), sourced from various life forms, emerge as promising contenders. These endogenous peptides, also known host defense (HDPs), play crucial roles in immune defenses against infections and exhibit potential combating cancers. With their diverse defensive functions, plant-derived AMPs, such thionins defensins, offer a rich repertoire of properties. Insects, amphibians, animals contribute unique AMPs like cecropins, temporins, cathelicidins, showcasing broad-spectrum activities bacteria, fungi, viruses. Understanding these natural holds significant for developing effective targeted therapies infectious diseases. Antimicrobial (AMPs) structural characteristics, including α-helical, β-sheet, extended, loop peptides. Environmental conditions influence structure, connecting to changes cell membrane hydrophobicity. AMPs’ actions involve direct killing regulation, with additional depolarization. this review, we focus on that act anticancer agents mechanisms akin activity. Buforin particularly I II, derived histone H2A, demonstrate antibacterial potential. IIb its analogs show promise, selectivity cells. Despite the challenges, approach combat microbial resistance treatment. types, HeLa, breast, lung, ovarian, prostate, liver cancers, buforins inhibitory effects apoptosis induction. To address limitations stability bioavailability, researchers explore buforin-containing bioconjugates, covalently linked nanoparticles or liposomes. Bioconjugation enhances specificity-controlled release combats drug resistance, presenting avenue Clinical translation awaits further evaluation through vivo studies future clinical trials.

Язык: Английский

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Advances in liposome-based delivery of RNA therapeutics for cancer treatment

Progress in molecular biology and translational science, Год журнала: 2024, Номер unknown, С. 177 - 218

Опубликована: Янв. 1, 2024

Язык: Английский

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Novel hybrid system based on carboxymethyl chitosan hydrogel encapsulating drug loaded nanoparticles for prolonged release of Vancomycin in the treatment of bacterial infection

Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Phytochemical synergies in BK002: advanced molecular docking insights for targeted prostate cancer therapy

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 17, 2025

Achyranthes japonica (Miq.) Nakai (AJN) and Melandrium firmum (Siebold Zucc.) Rohrb. (MFR) are medicinal plants recognized for their bioactive phytochemicals, including ecdysteroids, anthraquinones, flavonoids. This study investigates the anticancer properties of key constituents these plants, focusing on BK002 formulation, a novel combination AJN MFR. Specifically, research employs advanced molecular docking in silico analyses to assess interactions compounds ecdysterone, inokosterone, 20-hydroxyecdysone (20-HE) with prostate cancer-related network proteins, 5α-reductase, CYP17, DNMT1, Dicer, PD-1, PD-L1. Molecular techniques were applied evaluate binding affinities contributions against cancer-hub targets. The primary focus was enzymes like 5α-reductase which central androgen biosynthesis, as well proteins such DNA methyltransferase 1 (DNMT1), programmed death-1 (PD-1), death ligand-1 (PD-L1). Based data from cancer patients, target networks identified, followed by analysis components BK002.In assessments conducted safety profiles compounds, providing insights into therapeutic potential. studies revealed that 20-hydroxyecdysonec demonstrated strong critical contributing potential reduction androgenic activity. These also exhibited significant inhibitory PD-L1, suggesting capacity interfere oncogenic immune evasion pathways. Ecdysterone, have ability pathways, favorable affinity further underscore agents cancer. findings provide rationale preclinical clinical investigations, supporting integration regimens aimed at modulating tumor progression responses.

Язык: Английский

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Evaluation of Cell Proliferation and Wound Healing Effects of Vitamin A Palmitate-Loaded PLGA/Chitosan-Coated PLGA Nanoparticles: Preparation, Characterization, Release, and Release Kinetics

ACS Omega, Год журнала: 2023, Номер 8(2), С. 2658 - 2668

Опубликована: Янв. 6, 2023

In this study, vitamin A palmitate (VAP)-loaded poly(lactic-co-glycolic acid) (PLGA)/chitosan-coated PLGA nanoparticle (NP) systems were prepared by the nanoprecipitation technique. The characterized parameters such as particle size, polydispersity index (PDI), ζ-potential, encapsulation efficiency, in vitro dissolution, and release kinetic study. Then, cytotoxicity wound healing profiles of designed NP formulations HaCaT (human keratinocyte skin cell lines) determined. size VAP-loaded NPs was obtained between 196.33 ± 0.65 669.23 5.49 nm. PDI data proved that all high quality monodisperse. While negative ζ-potential values Blank-NP-1 NP-1 encoded obtained, positive chitosan-coated NPs. studies observed rapid dissolution first 1-6 h, but prolonged VAP after dissolution. As a result culture activity studies, it determined NP-7 most effective. It thought reason for coded formulation with smallest concluded efficiency increased its structure. This study demonstrated similar effects systems, particular NP-7, which increases proliferation at lower concentrations (10 μg·mL-1) than alone (100 μg·mL-1). nanocarriers can be used pharmaceutical industry have been successfully produced results evaluated promising industry.

Язык: Английский

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