Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(15), С. 1136 - 1148
Опубликована: Март 29, 2024
Tumor
metastasis
is
a
complex
process
that
controlled
at
the
molecular
level
by
numerous
cytokines.
Primary
breast
and
prostate
tumors
most
commonly
metastasize
to
bone,
development
of
increasingly
accurate
targeted
nanocarrier
systems
has
become
research
focus
for
more
effective
anti-bone
therapy.
This
review
summarizes
mechanisms
bone
principles
methods
designing
bone-targeted
nanocarriers
then
provides
an
in-depth
treatment
in
context
chemotherapy,
photothermal
therapy,
gene
combination
Furthermore,
this
also
discusses
metastatic
primary
tumors,
providing
directions
design
nanodelivery
future
research.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
Current Topics in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(8), С. 686 - 721
Опубликована: Фев. 27, 2024
Nanocarriers
have
emerged
as
a
promising
class
of
nanoscale
materials
in
the
fields
drug
delivery
and
biomedical
applications.
Their
unique
properties,
such
high
surface
area-
tovolume
ratios
enhanced
permeability
retention
effects,
enable
targeted
therapeutic
agents
to
specific
tissues
or
cells.
However,
inherent
instability
nanocarriers
poses
significant
challenges
their
successful
application.
This
review
highlights
importance
nanocarrier
stability
applications
its
impact
on
biocompatibility,
delivery,
long
shelf
life,
performance,
efficacy,
reduced
side
prolonged
circulation
time,
delivery.
Enhancing
requires
careful
design,
engineering,
optimization
physical
chemical
parameters.
Various
strategies
cutting-edge
techniques
employed
improve
are
explored,
with
focus
By
understanding
advances
stability,
this
aims
contribute
development
implementation
nanocarrier-
based
therapies
clinical
settings,
advancing
field
nanomedicine.
Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(4)
Опубликована: Май 14, 2024
Colorectal
cancer
(CRC)
is
a
common
digestive
tract
tumor,
with
incidences
continuing
to
rise.
Although
modern
medicine
has
extended
the
survival
time
of
CRC
patients,
its
adverse
effects
and
financial
burden
cannot
be
ignored.
multi-step
process
can
caused
by
disturbance
gut
microbiome
chronic
inflammation's
stimulation.
Additionally,
presence
precancerous
lesions
also
risk
factor
for
CRC.
Consequently,
scientists
are
increasingly
interested
in
identifying
multi-target,
safe,
economical
herbal
natural
products.
This
paper
summarizes
berberine's
(BBR)
regulatory
mechanisms
occurrence
development
The
findings
indicate
that
BBR
regulates
homeostasis
controls
mucosal
inflammation
prevent
In
stage,
inhibits
cell
proliferation,
invasion,
metastasis,
blocks
cycle,
induces
apoptosis,
metabolism,
angiogenesis,
enhances
chemosensitivity.
plays
role
overall
management
Therefore,
using
as
an
adjunct
prevention
treatment
could
become
future
trend
oncology.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1988 - 1988
Опубликована: Фев. 25, 2025
Colorectal
cancer
(CRC)
is
a
major
cause
of
cancer-related
mortality
worldwide,
with
significant
impact
on
public
health.
Current
treatment
options
include
surgery,
chemotherapy,
radiotherapy,
molecular-targeted
therapy,
and
immunotherapy.
Despite
advancements
in
these
therapeutic
modalities,
resistance
remains
challenge,
often
leading
to
failure,
poor
progression-free
survival,
recurrence.
Mechanisms
CRC
are
multifaceted,
involving
genetic
mutations,
epigenetic
alterations,
tumor
heterogeneity,
the
microenvironment.
Understanding
mechanisms
at
molecular
level
crucial
for
identifying
novel
targets
developing
strategies
overcome
resistance.
This
review
provides
an
overview
diverse
driving
drug
sporadic
discusses
currently
under
investigation
counteract
this
Several
promising
being
explored,
including
targeting
transport,
key
signaling
pathways,
DNA
damage
response,
cell
death
modifications,
stem
cells,
The
integration
emerging
approaches
that
target
aims
enhance
efficacy
current
treatments
improve
patient
outcomes.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2461 - 2473
Опубликована: Фев. 1, 2025
Ferroptosis
is
a
type
of
iron-dependent
programmed
cell
death
characterized
by
depletion
glutathione.
Although
generally
less
harmful
to
normal
cells,
in
tumor
the
high
demand
for
iron
ions
provides
conditions
conducive
ferroptosis.
In
this
review,
we
provide
an
overview
recent
progress
research
on
regulation
ferroptosis
summarizing
and
assessing
current
state,
trends,
applications
nanomaterials
cells.
Given
advantages
terms
targeting,
safety,
improved
drug
efficacy,
reduced
side
effects,
these
materials
are
considered
have
potential
therapeutic
value
modulating
cells
via
different
mechanisms.
respect,
describe
methods
modifying
interfering
with
glutathione
activity
lipid
peroxidation.
The
development
that
can
be
applied
induce
or
inhibit
anticipated
new
options
treatment
diverse
range
diseases.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 4143 - 4170
Опубликована: Июль 1, 2023
Abstract:
The
diagnosis
of
gastrointestinal
(GI)
diseases
currently
relies
primarily
on
invasive
procedures
like
digestive
endoscopy.
However,
these
can
cause
discomfort,
respiratory
issues,
and
bacterial
infections
in
patients,
both
during
after
the
examination.
In
recent
years,
nanomedicine
has
emerged
as
a
promising
field,
providing
significant
advancements
diagnostic
techniques.
Nanoprobes,
particular,
offer
distinct
advantages,
such
high
specificity
sensitivity
detecting
GI
diseases.
Integration
nanoprobes
with
advanced
imaging
techniques,
nuclear
magnetic
resonance,
optical
fluorescence
imaging,
tomography,
correlation
significantly
enhanced
detection
capabilities
for
tumors
inflammatory
bowel
disease
(IBD).
This
synergy
enables
early
precise
staging
disorders.
Among
nanoparticles
investigated
clinical
applications,
superparamagnetic
iron
oxide,
quantum
dots,
single
carbon
nanotubes,
nanocages
have
extensively
studied
utilized
agents.
review
aimed
to
provide
insights
into
potential
applications
modern
specific
focus
their
role
facilitating
range
disorders,
including
IBD
colorectal
cancer
(CRC).
Additionally,
we
discussed
challenges
associated
implementation
nanotechnology-based
diagnostics
explored
future
prospects
translation
this
field.
Keywords:
nano-diagnostics,
gastroenterology,
tumor,
Biology,
Год журнала:
2022,
Номер
11(11), С. 1642 - 1642
Опубликована: Ноя. 9, 2022
Colorectal
cancer
is
the
third
most
diagnosed
worldwide
and
second
prevalent
cause
of
cancer-related
mortality.
It
believed
that
alterations
within
gut
microbiome
may
impact
development
progression
cancer.
Additionally,
diet
an
individual
maintains
amount
alcohol
consumed
can
alter
microbiome,
thus
impacting
colorectal
A
focused
on
fiber
intake
considered
beneficial,
as
it
contains
short-chain
fatty
acids
such
butyrate,
which
have
antitumor
properties.
Furthermore,
current
treatment
strategies,
chemotherapy,
various
side
effects.
In
this
review,
we
discuss
role
oral
bacteria
in
relation
to
We
also
deliberate
consumption
Moreover,
influence
metabolites
importance
inflammation
are
explained.
Finally,
potential
therapies
fecal
microbiota
transfer
post/prebiotics
elaborated
on.
To
further
comprehend
risk
factors
cancer,
future
studies
warranted
determine
precise
mechanisms
action
between
carcinogenesis
order
develop
target
microbial
dysbiosis.
Molecular Therapy — Nucleic Acids,
Год журнала:
2023,
Номер
32, С. 371 - 384
Опубликована: Апрель 4, 2023
Micro-RNAs
(miRNAs)
control
gene
expression
at
the
post-transcriptional
level
and
are
widely
involved
in
carcinogenesis,
playing
a
role
as
both
oncogenes
tumor
suppressors.
MiRNAs
act
potent
therapeutic
weapon
cancer,
but
their
potential
use
is
limited
by
off-target
effect
due
to
nonspecific
distribution
normal
tissues.
The
encapsulation
of
miRNAs
nanostructured
carriers
allows
targeted
effects
aimed
destroy
cancer
cells,
without
affecting
healthy
Due
small
size
optimal
surface/size
ratio,
nanoparticles
(NPs)
envelop,
protect,
release
miRNAs,
representing
promising
strategy
treatment.
In
present
review,
we
discuss
latest
advances
field
miRNA-encapsulating
NPs
focusing
on
colorectal
its
metastatic
forms,
one
most
common
malignancies
worldwide.
