Current Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 30(23), P. 2592 - 2594
Published: Dec. 29, 2022
Language: Английский
Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 185, P. 103980 - 103980
Published: March 29, 2023
Language: Английский
Citations
27
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)
Published: May 1, 2024
Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives
Language: Английский
Citations
11
Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(8), P. 686 - 721
Published: Feb. 27, 2024
Nanocarriers have emerged as a promising class of nanoscale materials in the fields drug delivery and biomedical applications. Their unique properties, such high surface area- tovolume ratios enhanced permeability retention effects, enable targeted therapeutic agents to specific tissues or cells. However, inherent instability nanocarriers poses significant challenges their successful application. This review highlights importance nanocarrier stability applications its impact on biocompatibility, delivery, long shelf life, performance, efficacy, reduced side prolonged circulation time, delivery. Enhancing requires careful design, engineering, optimization physical chemical parameters. Various strategies cutting-edge techniques employed improve are explored, with focus By understanding advances stability, this aims contribute development implementation nanocarrier- based therapies clinical settings, advancing field nanomedicine.
Language: Английский
Citations
10
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2461 - 2473
Published: Feb. 1, 2025
Ferroptosis is a type of iron-dependent programmed cell death characterized by depletion glutathione. Although generally less harmful to normal cells, in tumor the high demand for iron ions provides conditions conducive ferroptosis. In this review, we provide an overview recent progress research on regulation ferroptosis summarizing and assessing current state, trends, applications nanomaterials cells. Given advantages terms targeting, safety, improved drug efficacy, reduced side effects, these materials are considered have potential therapeutic value modulating cells via different mechanisms. respect, describe methods modifying interfering with glutathione activity lipid peroxidation. The development that can be applied induce or inhibit anticipated new options treatment diverse range diseases.
Language: Английский
Citations
1
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4143 - 4170
Published: July 1, 2023
Abstract: The diagnosis of gastrointestinal (GI) diseases currently relies primarily on invasive procedures like digestive endoscopy. However, these can cause discomfort, respiratory issues, and bacterial infections in patients, both during after the examination. In recent years, nanomedicine has emerged as a promising field, providing significant advancements diagnostic techniques. Nanoprobes, particular, offer distinct advantages, such high specificity sensitivity detecting GI diseases. Integration nanoprobes with advanced imaging techniques, nuclear magnetic resonance, optical fluorescence imaging, tomography, correlation significantly enhanced detection capabilities for tumors inflammatory bowel disease (IBD). This synergy enables early precise staging disorders. Among nanoparticles investigated clinical applications, superparamagnetic iron oxide, quantum dots, single carbon nanotubes, nanocages have extensively studied utilized agents. review aimed to provide insights into potential applications modern specific focus their role facilitating range disorders, including IBD colorectal cancer (CRC). Additionally, we discussed challenges associated implementation nanotechnology-based diagnostics explored future prospects translation this field. Keywords: nano-diagnostics, gastroenterology, tumor,
Language: Английский
Citations
17
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(4)
Published: May 14, 2024
Colorectal cancer (CRC) is a common digestive tract tumor, with incidences continuing to rise. Although modern medicine has extended the survival time of CRC patients, its adverse effects and financial burden cannot be ignored. multi-step process can caused by disturbance gut microbiome chronic inflammation's stimulation. Additionally, presence precancerous lesions also risk factor for CRC. Consequently, scientists are increasingly interested in identifying multi-target, safe, economical herbal natural products. This paper summarizes berberine's (BBR) regulatory mechanisms occurrence development The findings indicate that BBR regulates homeostasis controls mucosal inflammation prevent In stage, inhibits cell proliferation, invasion, metastasis, blocks cycle, induces apoptosis, metabolism, angiogenesis, enhances chemosensitivity. plays role overall management Therefore, using as an adjunct prevention treatment could become future trend oncology.
Language: Английский
Citations
8
Biology, Journal Year: 2022, Volume and Issue: 11(11), P. 1642 - 1642
Published: Nov. 9, 2022
Colorectal cancer is the third most diagnosed worldwide and second prevalent cause of cancer-related mortality. It believed that alterations within gut microbiome may impact development progression cancer. Additionally, diet an individual maintains amount alcohol consumed can alter microbiome, thus impacting colorectal A focused on fiber intake considered beneficial, as it contains short-chain fatty acids such butyrate, which have antitumor properties. Furthermore, current treatment strategies, chemotherapy, various side effects. In this review, we discuss role oral bacteria in relation to We also deliberate consumption Moreover, influence metabolites importance inflammation are explained. Finally, potential therapies fecal microbiota transfer post/prebiotics elaborated on. To further comprehend risk factors cancer, future studies warranted determine precise mechanisms action between carcinogenesis order develop target microbial dysbiosis.
Language: Английский
Citations
23
Molecular Therapy — Nucleic Acids, Journal Year: 2023, Volume and Issue: 32, P. 371 - 384
Published: April 4, 2023
Micro-RNAs (miRNAs) control gene expression at the post-transcriptional level and are widely involved in carcinogenesis, playing a role as both oncogenes tumor suppressors. MiRNAs act potent therapeutic weapon cancer, but their potential use is limited by off-target effect due to nonspecific distribution normal tissues. The encapsulation of miRNAs nanostructured carriers allows targeted effects aimed destroy cancer cells, without affecting healthy Due small size optimal surface/size ratio, nanoparticles (NPs) envelop, protect, release miRNAs, representing promising strategy treatment. In present review, we discuss latest advances field miRNA-encapsulating NPs focusing on colorectal its metastatic forms, one most common malignancies worldwide.
Language: Английский
Citations
16
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3919 - 3942
Published: May 1, 2024
Abstract: Typical physiological characteristics of tumors, such as weak acidity, low oxygen content, and upregulation certain enzymes in the tumor microenvironment (TME), provide survival advantages when exposed to targeted attacks by drugs responsive nanomedicines. Consequently, cancer treatment has significantly progressed recent years. However, evolution adaptation still pose many challenges for current methods. Therefore, efficient precise treatments require an understanding heterogeneity degree various factors cells during exploit typical TME manage mutation process. The highly heterogeneous infiltrating stromal cells, immune extracellular components collectively form a unique TME, which plays crucial role malignancy, including proliferation, invasion, metastasis, escape. development new methods that can adapt evolutionary tumors become intense focus research. This paper explores latest evolution, focusing on how use antigens shape their "new faces"; system cytotoxic T regulatory macrophages, natural killer help "invisible", is, escape; whether diverse cancer-associated fibroblasts support coordination tumors; it is possible attack reverse. discusses limitations therapy driven future strategies potential intelligent nanomedicines, systematic adaptive methods, meet this therapeutic challenge. Keywords: smart nanomedicine,
Language: Английский
Citations
4
Smart Materials in Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0