ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(17), С. 21400 - 21414
Опубликована: Апрель 19, 2024
Morin,
a
naturally
occurring
bioactive
compound
shows
great
potential
as
an
antioxidant,
anti-inflammatory
agent,
and
regulator
of
blood
glucose
levels.
However,
its
low
water
solubility,
poor
lipid
limited
bioavailability,
rapid
clearance
in
vivo
hinder
application
regulation.
To
address
these
limitations,
we
report
enzymatically
synthesized
nanosized
morin
particle
(MNs)
encapsulated
sodium
alginate
microgels
(M@SA).
This
approach
significantly
enhances
morin's
delivery
efficiency
therapeutic
efficacy
Utilizing
horseradish
peroxidase,
MNs
averaging
305.7
±
88.7
nm
size.
These
were
then
via
electrohydrodynamic
microdroplet
spraying
to
form
M@SA
microgels.
In
studies
revealed
that
demonstrated
prolonged
intestinal
retention
superior
compared
with
unmodified
alone.
Moreover,
notably
improved
uptake
HepG2
cells.
Furthermore,
effectively
regulated
glucose,
profiles,
oxidative
stress
diabetic
mice
while
mitigating
liver,
kidney,
pancreatic
damage
enhancing
responses.
Our
findings
propose
promising
strategy
for
the
oral
administration
natural
compounds
regulation,
implications
broader
applications.
Current Opinion in Colloid & Interface Science,
Год журнала:
2024,
Номер
72, С. 101817 - 101817
Опубликована: Май 28, 2024
Amphiphilic
lipids
are
essential
biomolecules,
critical
components
in
nature's
functional
materials,
and
crucial
nutrients
food.
Being
sustainable,
biocompatible,
biodegradable
with
versatile
structural
properties,
they
have
great
potential
as
building
blocks
for
innovative
food
materials.
They
can
tailor
factors
including
texture,
mouthfeel,
appearance,
nutrient
delivery.
Their
analysis
from
the
angstrom
to
micrometer
range
lies
at
core
of
material
design
is
fundamental
their
further
biological
understanding.
We
discuss
recent
advances
colloidal
structure
formation
challenges
characterizing
structures
dynamics
lipid-based
materials
on
microstructural
level.
provide
examples
how
lipid
self-assemblies,
particularly
lyotropic
liquid
crystalline
structures,
enhance
The
interdisciplinary
development
this
growing
research
field
helps
explore
new
functionalities
applications.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(8), С. 3599 - 3619
Опубликована: Фев. 18, 2023
The
prevalence
of
neurodegenerative,
cerebrovascular,
and
psychiatric
diseases
other
neurological
disorders
has
increased
dramatically
worldwide.
Fucoxanthin
is
an
algal
pigment
with
many
biological
functions,
there
rising
evidence
that
fucoxanthin
plays
a
preventive
therapeutic
role
in
disorders.
This
review
focuses
on
the
metabolism,
bioavailability,
blood–brain
barrier
penetration
fucoxanthin.
Furthermore,
neuroprotective
potential
neurodegenerative
diseases,
cerebrovascular
as
well
such
epilepsy,
neuropathic
pain,
brain
tumors
by
acting
multiple
targets
will
be
summarized.
include
regulating
apoptosis,
reducing
oxidative
stress,
activating
autophagy
pathway,
inhibiting
Aβ
aggregation,
improving
dopamine
secretion,
α-synuclein
attenuating
neuroinflammation,
modulating
gut
microbiota,
brain-derived
neurotrophic
factor,
etc.
Additionally,
we
look
forward
to
brain-targeted
oral
transport
systems
due
low
bioavailability
permeability
We
also
propose
exploring
systemic
mechanisms
metabolism
through
gut–brain
process
envision
new
for
act
central
nervous
system.
Finally,
dietary
delivery
interventions
achieve
effects
provides
reference
application
neural
field.
Nanomaterials,
Год журнала:
2022,
Номер
12(13), С. 2267 - 2267
Опубликована: Июнь 30, 2022
Enabling
challenging
applications
of
nanomedicine
and
precision
medicine
in
the
treatment
neurodegenerative
disorders
requires
deeper
investigations
nanocarrier-mediated
biomolecular
delivery
for
neuronal
targeting
recovery.
The
successful
use
macromolecular
biotherapeutics
(recombinant
growth
factors,
antibodies,
enzymes,
synthetic
peptides,
cell-penetrating
peptide–drug
conjugates,
RNAi
sequences)
clinical
developments
regeneration
should
benefit
from
recent
strategies
enhancement
their
bioavailability.
We
highlight
advances
development
nanoscale
materials
drug
disorders.
emphasis
is
placed
on
nanoformulations
brain-derived
neurotrophic
factor
(BDNF)
using
different
types
lipidic
nanocarriers
(liposomes,
liquid
crystalline
or
solid
lipid
nanoparticles)
polymer-based
scaffolds,
nanofibers
hydrogels.
Self-assembled
soft-matter
show
favorable
neuroprotective
characteristics,
safety,
efficacy
profiles
to
central
peripheral
nervous
systems.
summarized
here
indicate
that
biomolecule-loaded
nanoparticles
injectable
hydrogels
can
improve
survival
reduce
tissue
injury.
Certain
recently
reported
dysfunctions
long-COVID-19
survivors
represent
early
manifestations
pathologies.
Therefore,
BDNF
systems
may
also
help
prospective
studies
recovery
long-term
COVID-19
neurological
complications
be
considered
as
promising
personalized
prevention
retarding
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(17), С. 21400 - 21414
Опубликована: Апрель 19, 2024
Morin,
a
naturally
occurring
bioactive
compound
shows
great
potential
as
an
antioxidant,
anti-inflammatory
agent,
and
regulator
of
blood
glucose
levels.
However,
its
low
water
solubility,
poor
lipid
limited
bioavailability,
rapid
clearance
in
vivo
hinder
application
regulation.
To
address
these
limitations,
we
report
enzymatically
synthesized
nanosized
morin
particle
(MNs)
encapsulated
sodium
alginate
microgels
(M@SA).
This
approach
significantly
enhances
morin's
delivery
efficiency
therapeutic
efficacy
Utilizing
horseradish
peroxidase,
MNs
averaging
305.7
±
88.7
nm
size.
These
were
then
via
electrohydrodynamic
microdroplet
spraying
to
form
M@SA
microgels.
In
studies
revealed
that
demonstrated
prolonged
intestinal
retention
superior
compared
with
unmodified
alone.
Moreover,
notably
improved
uptake
HepG2
cells.
Furthermore,
effectively
regulated
glucose,
profiles,
oxidative
stress
diabetic
mice
while
mitigating
liver,
kidney,
pancreatic
damage
enhancing
responses.
Our
findings
propose
promising
strategy
for
the
oral
administration
natural
compounds
regulation,
implications
broader
applications.
