Amphiphilic lipids for food functionality

Current Opinion in Colloid & Interface Science, Journal Year: 2024, Volume and Issue: 72, P. 101817 - 101817

Published: May 28, 2024

Amphiphilic lipids are essential biomolecules, critical components in nature's functional materials, and crucial nutrients food. Being sustainable, biocompatible, biodegradable with versatile structural properties, they have great potential as building blocks for innovative food materials. They can tailor factors including texture, mouthfeel, appearance, nutrient delivery. Their analysis from the angstrom to micrometer range lies at core of material design is fundamental their further biological understanding. We discuss recent advances colloidal structure formation challenges characterizing structures dynamics lipid-based materials on microstructural level. provide examples how lipid self-assemblies, particularly lyotropic liquid crystalline structures, enhance The interdisciplinary development this growing research field helps explore new functionalities applications.

Language: Английский

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Dietary Protective Potential of Fucoxanthin as an Active Food Component on Neurological Disorders

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(8), P. 3599 - 3619

Published: Feb. 18, 2023

The prevalence of neurodegenerative, cerebrovascular, and psychiatric diseases other neurological disorders has increased dramatically worldwide. Fucoxanthin is an algal pigment with many biological functions, there rising evidence that fucoxanthin plays a preventive therapeutic role in disorders. This review focuses on the metabolism, bioavailability, blood–brain barrier penetration fucoxanthin. Furthermore, neuroprotective potential neurodegenerative diseases, cerebrovascular as well such epilepsy, neuropathic pain, brain tumors by acting multiple targets will be summarized. include regulating apoptosis, reducing oxidative stress, activating autophagy pathway, inhibiting Aβ aggregation, improving dopamine secretion, α-synuclein attenuating neuroinflammation, modulating gut microbiota, brain-derived neurotrophic factor, etc. Additionally, we look forward to brain-targeted oral transport systems due low bioavailability permeability We also propose exploring systemic mechanisms metabolism through gut–brain process envision new for act central nervous system. Finally, dietary delivery interventions achieve effects provides reference application neural field.

Language: Английский

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Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(13), P. 2267 - 2267

Published: June 30, 2022

Enabling challenging applications of nanomedicine and precision medicine in the treatment neurodegenerative disorders requires deeper investigations nanocarrier-mediated biomolecular delivery for neuronal targeting recovery. The successful use macromolecular biotherapeutics (recombinant growth factors, antibodies, enzymes, synthetic peptides, cell-penetrating peptide–drug conjugates, RNAi sequences) clinical developments regeneration should benefit from recent strategies enhancement their bioavailability. We highlight advances development nanoscale materials drug disorders. emphasis is placed on nanoformulations brain-derived neurotrophic factor (BDNF) using different types lipidic nanocarriers (liposomes, liquid crystalline or solid lipid nanoparticles) polymer-based scaffolds, nanofibers hydrogels. Self-assembled soft-matter show favorable neuroprotective characteristics, safety, efficacy profiles to central peripheral nervous systems. summarized here indicate that biomolecule-loaded nanoparticles injectable hydrogels can improve survival reduce tissue injury. Certain recently reported dysfunctions long-COVID-19 survivors represent early manifestations pathologies. Therefore, BDNF systems may also help prospective studies recovery long-term COVID-19 neurological complications be considered as promising personalized prevention retarding

Language: Английский

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Update on Therapeutic potential of emerging nanoformulations of phytocompounds in Alzheimer's and Parkinson's disease

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 79, P. 104074 - 104074

Published: Dec. 9, 2022

Language: Английский

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Morin-Based Nanoparticles for Regulation of Blood Glucose

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 21400 - 21414

Published: April 19, 2024

Morin, a naturally occurring bioactive compound shows great potential as an antioxidant, anti-inflammatory agent, and regulator of blood glucose levels. However, its low water solubility, poor lipid limited bioavailability, rapid clearance in vivo hinder application regulation. To address these limitations, we report enzymatically synthesized nanosized morin particle (MNs) encapsulated sodium alginate microgels (M@SA). This approach significantly enhances morin's delivery efficiency therapeutic efficacy Utilizing horseradish peroxidase, MNs averaging 305.7 ± 88.7 nm size. These were then via electrohydrodynamic microdroplet spraying to form M@SA microgels. In studies revealed that demonstrated prolonged intestinal retention superior compared with unmodified alone. Moreover, notably improved uptake HepG2 cells. Furthermore, effectively regulated glucose, profiles, oxidative stress diabetic mice while mitigating liver, kidney, pancreatic damage enhancing responses. Our findings propose promising strategy for the oral administration natural compounds regulation, implications broader applications.

Language: Английский

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