Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 9, 2023
Acute
kidney
injury
(AKI)
is
a
clinical
syndrome
that
results
from
rapid
decline
in
renal
structure
or
functional
impairment
with
the
main
pathological
feature
of
sublethal
and
lethal
damage
to
tubular
cells.
However,
many
potential
therapeutic
agents
cannot
achieve
desired
effect
because
their
poor
pharmacokinetics
short
retention
time
kidneys.
With
recent
emergence
progress
nanotechnology,
nanodrugs
unique
physicochemical
properties
could
prolong
circulation
time,
enhance
efficient
targeted
delivery,
elevate
accumulation
therapeutics
can
cross
glomerular
filtration
barrier
indicate
comprehensive
application
prospects
prevention
treatment
AKI.
In
this
review,
various
types
nanosystems
(such
as
liposomes,
polymeric
nanosystems,
inorganic
nanoparticles
cell-derived
extracellular
vesicles)
are
designed
applied
improve
drug
formation,
which
further
relieve
burden
on
kidneys
caused
by
final
cumulative
dose
drugs
conventional
treatments.
Moreover,
passive
active
targeting
also
reduce
total
off-target
adverse
effects
other
organs.
Nanodelivery
systems
for
treating
AKI
alleviate
oxidative
stress-induced
cell
regulate
inflammatory
microenvironment
summarized.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Фев. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Nanomaterials,
Год журнала:
2024,
Номер
14(3), С. 244 - 244
Опубликована: Янв. 23, 2024
A
nanozyme
is
a
nanoscale
material
having
enzyme-like
properties.
It
exhibits
several
superior
properties,
including
low
preparation
cost,
robust
catalytic
activity,
and
long-term
storage
at
ambient
temperatures.
Moreover,
high
stability
enables
repetitive
use
in
multiple
reactions.
Hence,
it
considered
potential
replacement
for
natural
enzymes.
Enormous
research
interest
nanozymes
the
past
two
decades
has
made
imperative
to
look
better
enzyme-mimicking
materials
biomedical
applications.
Given
this,
on
metal–organic
frameworks
(MOFs)
as
gained
momentum.
MOFs
are
advanced
hybrid
of
inorganic
metal
ions
organic
ligands.
Their
distinct
composition,
adaptable
pore
size,
structural
diversity,
ease
tunability
physicochemical
properties
enable
mimic
activities
act
promising
candidates.
This
review
aims
discuss
recent
advances
development
MOF-based
(MOF-NZs)
highlight
their
applications
field
biomedicine.
Firstly,
different
enzyme-mimetic
exhibited
by
discussed,
insights
given
into
various
strategies
achieve
them.
Modification
functionalization
deliberated
obtain
MOF-NZs
with
enhanced
activity.
Subsequently,
biosensing
therapeutics
domain
discussed.
Finally,
concluded
giving
challenges
encountered
possible
directions
overcome
them
future.
With
this
review,
we
aim
encourage
consolidated
efforts
across
enzyme
engineering,
nanotechnology,
science,
biomedicine
disciplines
inspire
exciting
innovations
emerging
yet
field.
ACS Nano,
Год журнала:
2024,
Номер
18(20), С. 12639 - 12671
Опубликована: Май 8, 2024
Since
the
discovery
of
ferromagnetic
nanoparticles
Fe3O4
that
exhibit
enzyme-like
activity
in
2007,
research
on
nanoenzymes
has
made
significant
progress.
With
in-depth
study
various
and
rapid
development
related
nanotechnology,
have
emerged
as
a
promising
alternative
to
natural
enzymes.
Within
nanozymes,
there
is
category
metal-based
single-atom
nanozymes
been
rapidly
developed
due
low
cast,
convenient
preparation,
long
storage,
less
immunogenicity,
especially
higher
efficiency.
More
importantly,
possess
capacity
scavenge
reactive
oxygen
species
through
mechanisms,
which
beneficial
tissue
repair
process.
Herein,
this
paper
systemically
highlights
types
metal
their
catalytic
recent
applications
repair.
The
existing
challenges
are
identified
prospects
future
composed
metallic
nanomaterials
proposed.
We
hope
review
will
illuminate
potential
repair,
encouraging
sequential
clinical
translation.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(45), С. 50677 - 50691
Опубликована: Ноя. 3, 2022
Various
injury
defense
and
repair
functions
are
performed
by
the
skin.
Free
radicals
secreted
after
cause
oxidative
stress
inflammatory
responses,
which
make
wound
healing
difficult.
However,
current
metal
nanomaterials
for
do
not
have
sufficient
catalytic
activity
or
complex
material
design
cannot
properly
fit
wounds.
Therefore,
it
is
imperative
to
develop
more
effective
therapeutic
approaches.
This
study
investigated
effect
of
Ni4Cu2
hollow
nanospheres
composited
with
F127
hydrogel
on
promoting
applying
them
exhibited
a
superior
spatial
structure,
contained
many
sites,
could
be
synthesized
in
simple
manner.
In
vitro
experiments
showed
that
had
superoxide
dismutase-like
promoted
fibroblast
migration,
angiogenesis,
macrophage
polarization.
F127,
thermosensitive,
nontoxic,
phase-change
porous
material,
has
proven
an
choice
injectable
sprayable
medical
dressings.
were
mixed
without
significantly
affecting
its
performance.
addition
adapting
complex,
irregular
gaps
acute
wounds,
mixture
lengthened
nanozyme
release
time,
enhanced
healing.
Based
animal
experiments,
Ni4Cu2/F127
composite
effectively
healing,
epithelial
regeneration,
formation
skin
appendages
such
as
hair
follicles
mice.
Furthermore,
was
nontoxic
animals
high
biological
safety.
The
provided
innovative
strategy
hydrogels
treatment
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(9), С. 3577 - 3599
Опубликована: Авг. 17, 2023
Nanozymes
are
nanoparticles
with
intrinsic
enzyme-mimicking
properties
that
have
become
more
prevalent
because
of
their
ability
to
outperform
conventional
enzymes
by
overcoming
drawbacks
related
stability,
cost,
and
storage.
the
potential
manipulate
active
sites
natural
enzymes,
which
is
why
they
considered
promising
candidates
function
as
enzyme
mimetics.
Several
microscopy-
spectroscopy-based
techniques
been
used
for
characterization
nanozymes.
To
date,
a
wide
range
nanozymes,
including
catalase,
oxidase,
peroxidase,
superoxide
dismutase,
designed
effectively
mimic
enzymes.
The
activity
nanozymes
can
be
controlled
regulating
structural
morphological
aspects
multifaceted
benefits,
exploited
on
large
scale
application
in
biomedical
sector.
versatility
aids
monitoring
treating
cancer,
other
neurodegenerative
diseases,
metabolic
disorders.
Due
compelling
advantages
significant
research
advancements
made
this
area.
Although
act
potent
mimetics
specificities
suboptimal,
there
still
room
diversification
analytical
purposes.
Designing
diverse
nanozyme
systems
sensitive
one
or
substrates
through
specialized
has
subject
an
in-depth
study.
Hence,
we
believe
stimuli-responsive
may
open
avenues
diagnosis
treatment
fusing
catalytic
nanomaterial
systems.
Abstract
Chronic
diabetic
wounds
remain
a
worldwide
challenge
for
both
the
clinic
and
research.
Given
vicious
circle
of
oxidative
stress
inflammatory
response
as
well
impaired
angiogenesis
wound
tissues,
healing
process
is
disturbed
poorly
responds
to
current
treatments.
In
this
work,
nickel‐based
metal‐organic
framework
(MOF,
Ni‐HHTP)
with
excellent
antioxidant
activity
proangiogenic
function
developed
accelerate
chronic
wounds.
The
Ni‐HHTP
can
mimic
enzymatic
catalytic
activities
enzymes
eliminate
multi‐types
reactive
species
through
electron
transfer
reactions,
which
protects
cells
from
stress‐related
damage.
Moreover,
Ni‐based
MOF
promote
cell
migration
by
activating
transforming
growth
factor‐β1
(TGF‐β1)
in
vitro
reprogram
macrophages
anti‐inflammatory
phenotype.
Importantly,
effectively
promotes
suppressing
enhancing
vivo.
This
study
reports
versatile
promising
MOF‐based
nanozyme
healing,
may
be
extended
combination
other
dressings
enhance
management
or
non‐healing
