From Genesis to Old Age: Exploring the Immune System One Cell at a Time with Flow Cytometry DOI Creative Commons
Anis Larbi

Biomedicines, Год журнала: 2024, Номер 12(7), С. 1469 - 1469

Опубликована: Июль 3, 2024

The immune system is a highly complex and tightly regulated that plays crucial role in protecting the body against external threats, such as pathogens, internal abnormalities, like cancer cells. It undergoes development during fetal stages continuously learns from each encounter with allowing it to develop immunological memory provide wide range of protection. Over time, after numerous encounters years functioning, can begin show signs erosion, which commonly named immunosenescence. In this review, we aim explore how responds initial antigens handles persistent stimulations throughout person's lifetime. Our understanding has greatly benefited advanced technologies flow cytometry. context, will discuss valuable contribution cytometry enhancing our knowledge behavior aging, specific focus on T-cells. Moreover, expand discussion cytometry-based assessment extracellular vesicles, recently discovered communication channel biology, their implications for functioning.

Язык: Английский

Vitamin K: Infection, Inflammation, and Auto-Immunity DOI Creative Commons
Yuanyuan Xie, Shifang Li,

Dinan Wu

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 1147 - 1160

Опубликована: Фев. 1, 2024

Vitamin K (VK) comprises a group of substances with chlorophyll quinone bioactivity and exists in nature the form VK1 VK2.As its initial recognition originated from ability to promote blood coagulation, it is known as coagulation vitamin.However, based on extensive research, VK has shown potential for prevention treatment various diseases.Studies demonstrating beneficial effects immunity, antioxidant capacity, intestinal microbiota regulation, epithelial development, bone protection have drawn growing interest recent years.This review article focuses mechanism action preventive therapeutic infections (eg, asthma, COVID-19), inflammation type 2 diabetes mellitus, Alzheimer's disease, Parkinson's cancer, aging, atherosclerosis) autoimmune disorders inflammatory bowel 1 multiple sclerosis, rheumatoid arthritis).In addition, VK-dependent proteins (VKDPs) are another crucial by which exerts anti-inflammatory immunomodulatory effects.This explores role preventing combating neurological abnormalities, treating diseases such cancer diabetes.Although current research appoints tool practical clinical applications infections, inflammation, diseases, future necessary elucidate more detail overcome limitations.

Язык: Английский

Процитировано

17
Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases DOI Creative Commons
Hanzhang Wu,

Jiahe Wei,

Yuefeng Yu

и другие.

Journal of Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related expansion blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate association between CHIP and established autoimmune diseases. We analyzed baseline data from 456,692 UK Biobank participants available whole-exome sequences. The primary outcome was 19 disorders. Associations among any (variant allele fraction ≥2%), large clones ≥10%), gene-specific subtypes incidence diseases were assessed using Cox regression. Mediation analysis performed explore role inflammation in link identified 17,433 11,970 at baseline. Participants 44% 43% higher risk for Crohn's disease, 25% 33% psoriasis, 13% 14% rheumatoid arthritis, 35% 55% vasculitis, respectively. status increased levels inflammatory markers, including white cell, platelets, neutrophils, neutrophil-to-lymphocyte ratio, overall mediation ratios 16.3% 7.1% 23.2% 7.2% vasculitis. an incident multiple diseases, potentially mediated elevated levels. Future research needed clarify mechanisms underlying these associations interventions reduce risk.

Язык: Английский

Процитировано

1
Inflammation and aging-related disease: A transdisciplinary inflammaging framework DOI
Brian J. Andonian, Joseph A. Hippensteel, Katrina Abuabara

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

9
Metabolic Checkpoints in Rheumatoid Arthritis DOI

Cornelia M. Weyand,

Jörg J. Goronzy

Seminars in Arthritis and Rheumatism, Год журнала: 2024, Номер unknown, С. 152586 - 152586

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

6
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis DOI
Abhinav Lamba, Veena Taneja

Immunological Reviews, Год журнала: 2024, Номер 325(1), С. 90 - 106

Опубликована: Июнь 12, 2024

Rheumatoid arthritis (RA) is considered a multifactorial condition where interaction between the genetic and environmental factors lead to immune dysregulation causing autoreactivity. While among various factors, HLA-DR4 DQ8, have been reported be strongest risk role of has unclear. Though events initiating autoreactivity remain unknown, mucosal origin RA gained attention based on recent observations with gut dysbiosis in patients. However, causality difficult prove humans. Mouse models, especially mice expressing RA-susceptible -resistant HLA class II genes helped unravel complex interactions microbiome. This review describes sex-biased preclinical discusses potential use endogenous commensals as indicators treatment efficacy well therapeutic tool suppress pro-inflammatory response rheumatoid arthritis.

Язык: Английский

Процитировано

5
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study DOI Creative Commons
Xiaomin Fu, Peng Qin, Fanghui Li

и другие.

Immunity & Ageing, Год журнала: 2023, Номер 20(1)

Опубликована: Дек. 15, 2023

Although the concept of declined immune function associated with cancer has been accepted extensively, real-world clinical studies focusing on analysis peripheral blood changes underlying ageing, immunity and are scarce.In this case-control study, we retrospectively analysed 1375 patients enrolled 275 age gender matched healthy individuals. Flow cytometry was conducted to assess changes. Further examined by SPSS 17.0 GraphPad Prism 9 software.Cancer showed obviously decreased CD3+ T, CD3+CD4+ Th, CD3+CD8+ CTL, CD19+ B, CD16+CD56+ NK cell counts lower percentage PD-1 (programmed death protein-1, PD-1) positive cells than control (P < 0.0001). For patients, reference range circulating PD-1+CD45+ cells, PD-1+CD3+ T PD-1+CD3+CD4+ Th PD-1+CD3+CD8+ CTL (Cytotoxic Lymphocyte, CTL) were 11.2% (95% CI 10.8%-11.6%), 15.5% 14.7%-16.0%), 15.4% 14.9%-16.0%) 14.5% 14.0%-15.5%), respectively. Moreover, reduction B accompanied stage advancing 0.05). stage, but elevated in aged male Additionally, varied across types, raised stage. Head neck, pancreatic, gynaecological lung demonstrated a higher level melanoma, prostate, breast 0.05).This study provides blood, confirms series accompanying cancer, expands our real world evidence better understand interactions immunity. shows similar tumor type distribution mutational burden (TMB), supports that it maybe potential predictive biomarker for checkpoint inhibitor therapy.

Язык: Английский

Процитировано

10
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice DOI
Peng Chen, Yulai Wang, Benhong Zhou

и другие.

Mechanisms of Ageing and Development, Год журнала: 2024, Номер 218, С. 111918 - 111918

Опубликована: Фев. 23, 2024

Язык: Английский

Процитировано

4
MicroRNA‐7 deficiency ameliorates d‐galactose‐induced aging in mice by regulating senescence of Kupffer cells DOI Creative Commons
Ya Wang,

Hui Qiu,

Shipeng Chen

и другие.

Aging Cell, Год журнала: 2024, Номер 23(6)

Опубликована: Март 17, 2024

Abstract Aging is intricately linked to immune system dysfunction. Recent studies have highlighted the biological function of microRNA‐7 (miR‐7) as a novel regulator cell and related diseases. However, potential role miR‐7 in aging remains unexplored. Here, we investigated contribution d ‐gal‐induced mice, focusing on its regulation senescent Kupffer cells. Our findings revealed that deficiency significantly ameliorated process, characterized by enhanced CD4 + T‐cell activation. adoptive transfer miR‐7‐deficient T cells failed improve age‐related phenotype. Further analysis showed reduced IL‐1β production liver tissue, inhibiting vivo slowed down process mice. Notably, mainly produced tissue expression was up‐regulated these Mechanistically, KLF4, target miR‐7, down‐regulated mouse model. Furthermore, also modulated NF‐κB activation through KLF4. In conclusion, our unveil highlighting KLF4/NF‐κB/IL‐1β pathways This research may enhance understanding miRNA‐based offer new avenues for intervention strategies process.

Язык: Английский

Процитировано

4
Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function DOI Creative Commons
Cara A. Reynolds, Sandra Pelka, Floralba Gjergjova

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(38)

Опубликована: Сен. 11, 2024

Chaperone-mediated autophagy (CMA) is a selective form of that contributes to the maintenance cellular homeostasis. CMA activity declines with age in most tissues and systems, including immune system, due reduction levels lysosome-associated membrane protein type 2A (LAMP2A), an essential component. In this study, we show overexpressing copy hLAMP2A within T cells since middle-age can prevent some their age-associated loss function. Our data support idea preserving LAMP2A expression through genetic means leads enhanced proliferative responses, decreased number regulatory cell populations, down-regulated inhibitory receptors by cells. During aging, elevated numbers these immunosuppressive populations significantly contribute downregulation responses. Using comparative proteomics, confirm preservation old mice prevents age-related changes both resting activated proteome. We also explore effect using first-in-class small molecule activators demonstrate improved response upon administration mice. conclude sustaining constitutes potentially viable therapeutic approach improving function age.

Язык: Английский

Процитировано

4
An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases DOI

Yudai Xu,

Zijian Wang, Shumin Li

и другие.

Science China Life Sciences, Год журнала: 2024, Номер unknown

Опубликована: Сен. 2, 2024

Язык: Английский

Процитировано

3