Cellular and Molecular Immunology, Год журнала: 2023, Номер 20(10), С. 1216 - 1231
Опубликована: Авг. 30, 2023
Язык: Английский
Trends in cancer, Год журнала: 2022, Номер 8(11), С. 901 - 914
Опубликована: Июль 28, 2022
Язык: Английский
Процитировано
155
Advanced Science, Год журнала: 2023, Номер 10(23)
Опубликована: Июнь 1, 2023
Colorectal cancer (CRC) is the most common of digestive system with high mortality and morbidity rates. Gut microbiota found in intestines, especially colorectum, has structured crosstalk interactions host that affect several physiological processes. The gut include CRC-promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis, CRC-protecting Clostridium butyricum, Streptococcus thermophilus, Lacticaseibacillus paracasei, which along other microorganisms, viruses fungi, play critical roles development CRC. Different features are identified patients early-onset CRC, combined different patterns between fecal intratumoral microbiota. may be beneficial diagnosis treatment CRC; some bacteria serve biomarkers while others regulators chemotherapy immunotherapy. Furthermore, metabolites produced by essential CRC cells. Harmful primary bile acids short-chain fatty acids, whereas others, including ursodeoxycholic acid butyrate, impede tumor progression. This review focuses on its metabolites, their potential development, diagnosis,
Язык: Английский
Процитировано
121
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Июль 23, 2022
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan delaying ageing various species such as yeast, drosophila, rodent, primate human. It emerges develop precision-nutrition therapeutics slow age-related biological processes treat diverse diseases. However, nutritive advantages frequently diversify among individuals well organs tissues, which brings challenges this field. In review, we summarize different forms of dietary interventions extensively prescribed improvement disease treatment pre-clinical or clinical. We discuss nutrient-mediated mechanisms including metabolic regulators, metabolism pathways, epigenetic circadian clocks. Comparably, describe diet-responsive effectors by influence endocrinic, immunological, microbial neural states responsible improving health preventing multiple diseases humans. Furthermore, expatiate patterns dietotheroapies, fasting, calorie-restricted diet, ketogenic high-fibre plants-based protein restriction diet with specific reduction amino acids microelements, potentially affecting morbid states. Altogether, emphasize profound nutritional therapy, highlight crosstalk explored critical factors individualized therapeutic approaches predictors.
Язык: Английский
Процитировано
104
Annual Review of Pathology Mechanisms of Disease, Год журнала: 2022, Номер 18(1), С. 467 - 492
Опубликована: Ноя. 2, 2022
Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared toward rapid proliferation, requiring nutrients and the removal cellular waste in nutrient-poor environments. Intestinal stem (ISCs), primary cell origin for CRCs, must adapt their along adenoma-carcinoma sequence to unique features complex microenvironment that include interactions with intestinal epithelial cells, immune stromal commensal microbes, dietary components. Emerging evidence implicates modifiable risk factors related environment, such as diet, important pathogenesis. Here, we focus on describing ISCs, diets influence initiation, genetics metabolism, tumor microenvironment. The mechanistic links between environmental factors, metabolic adaptations, enhancing or supporting tumorigenesis becoming better understood. Thus, greater knowledge holds promise improved prevention treatment.
Язык: Английский
Процитировано
103
Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(10), С. 697 - 715
Опубликована: Июль 24, 2023
Язык: Английский
Процитировано
61
Nature, Год журнала: 2024, Номер 627(8004), С. 636 - 645
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
49
Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 34(8), С. 489 - 501
Опубликована: Июнь 17, 2023
Cancer remains the second leading cause of mortality, with nearly 10 million deaths worldwide in 2020. In many cases, radiotherapy is used for its anticancer effects. However, radiation causes healthy tissue toxicity as a side effect. intra-abdominal and pelvic malignancies, bowel inevitably included field, causing radiation-induced enteritis dramatically affecting gut microbiome. This condition associated significant morbidity mortality that impairs cancer patients' survivors' quality life. Review provides critical overview main drivers modulating microenvironment homeostasis, disease, injury, focusing on microbial metabolites microorganisms influence epithelial regeneration upon injury.
Язык: Английский
Процитировано
45
Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(3), С. 495 - 500
Опубликована: Март 1, 2024
Abstract The intestinal epithelium is the first line of defense and acts as an interface between vast microbial world within gastrointestinal tract body’s internal milieu. not only facilitates nutrient absorption but also plays a key role in defending against pathogens regulating immune system. Central to maintaining healthy are stem cells (ISCs), which essential for replenishing throughout individual’s lifespan. Recent research has unveiled intricate interplay ISCs their niche, includes various cell types, extracellular components, signaling molecules. In this review, we delve into most recent advances ISC research, with focus on roles mucosal homeostasis how functionality influenced by niche environment. explored regulatory mechanisms that govern behavior, emphasizing dynamic adaptability face challenges. Understanding regulation impact aging environmental factors crucial advancing our knowledge developing translational approaches. Future studies should investigate interactive effects different risk function develop strategies improving regenerative capacity gut.
Язык: Английский
Процитировано
31
Nature Cancer, Год журнала: 2024, Номер 5(4), С. 546 - 556
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
21
Nature Reviews Gastroenterology & Hepatology, Год журнала: 2021, Номер 19(2), С. 93 - 94
Опубликована: Дек. 14, 2021
Язык: Английский
Процитировано
76