Experimental & Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
55(12), P. 2498 - 2507
Published: Dec. 1, 2023
Our
understanding
of
host-microbe
interactions
has
broadened
through
numerous
studies
over
the
past
decades.
However,
most
investigations
primarily
focus
on
dominant
members
within
ecosystems
while
neglecting
low-abundance
microorganisms.
Moreover,
laboratory
animals
usually
do
not
have
microorganisms
beyond
bacteria.
The
phenotypes
observed
in
animals,
including
immune
system,
displayed
notable
discrepancies
when
compared
to
real-world
observations
due
diverse
microbial
community
natural
environments.
Interestingly,
recent
unveiled
beneficial
roles
played
by
Despite
their
rarity,
these
keystone
taxa
play
a
pivotal
role
shaping
composition
and
fulfilling
specific
functions
host.
Consequently,
become
imperative
unravel
true
commensalism.
In
this
review,
we
provide
comprehensive
overview
important
findings
how
commensal
microorganisms,
bacteria,
fungi,
archaea,
protozoa,
interact
with
host
contribute
phenotypes,
emphasis
system.
Indeed,
vital
development
host's
influence
disease
status,
key
communities
niches.
Understanding
microbes
is
will
lead
better
relationships.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(23)
Published: June 1, 2023
Colorectal
cancer
(CRC)
is
the
most
common
of
digestive
system
with
high
mortality
and
morbidity
rates.
Gut
microbiota
found
in
intestines,
especially
colorectum,
has
structured
crosstalk
interactions
host
that
affect
several
physiological
processes.
The
gut
include
CRC-promoting
bacterial
species,
such
as
Fusobacterium
nucleatum,
Escherichia
coli,
Bacteroides
fragilis,
CRC-protecting
Clostridium
butyricum,
Streptococcus
thermophilus,
Lacticaseibacillus
paracasei,
which
along
other
microorganisms,
viruses
fungi,
play
critical
roles
development
CRC.
Different
features
are
identified
patients
early-onset
CRC,
combined
different
patterns
between
fecal
intratumoral
microbiota.
may
be
beneficial
diagnosis
treatment
CRC;
some
bacteria
serve
biomarkers
while
others
regulators
chemotherapy
immunotherapy.
Furthermore,
metabolites
produced
by
essential
CRC
cells.
Harmful
primary
bile
acids
short-chain
fatty
acids,
whereas
others,
including
ursodeoxycholic
acid
butyrate,
impede
tumor
progression.
This
review
focuses
on
its
metabolites,
their
potential
development,
diagnosis,
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: July 23, 2022
Nutriments
have
been
deemed
to
impact
all
physiopathologic
processes.
Recent
evidences
in
molecular
medicine
and
clinical
trials
demonstrated
that
adequate
nutrition
treatments
are
the
golden
criterion
for
extending
healthspan
delaying
ageing
various
species
such
as
yeast,
drosophila,
rodent,
primate
human.
It
emerges
develop
precision-nutrition
therapeutics
slow
age-related
biological
processes
treat
diverse
diseases.
However,
nutritive
advantages
frequently
diversify
among
individuals
well
organs
tissues,
which
brings
challenges
this
field.
In
review,
we
summarize
different
forms
of
dietary
interventions
extensively
prescribed
improvement
disease
treatment
pre-clinical
or
clinical.
We
discuss
nutrient-mediated
mechanisms
including
metabolic
regulators,
metabolism
pathways,
epigenetic
circadian
clocks.
Comparably,
describe
diet-responsive
effectors
by
influence
endocrinic,
immunological,
microbial
neural
states
responsible
improving
health
preventing
multiple
diseases
humans.
Furthermore,
expatiate
patterns
dietotheroapies,
fasting,
calorie-restricted
diet,
ketogenic
high-fibre
plants-based
protein
restriction
diet
with
specific
reduction
amino
acids
microelements,
potentially
affecting
morbid
states.
Altogether,
emphasize
profound
nutritional
therapy,
highlight
crosstalk
explored
critical
factors
individualized
therapeutic
approaches
predictors.
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2022,
Volume and Issue:
18(1), P. 467 - 492
Published: Nov. 2, 2022
Reprogrammed
metabolism
is
a
hallmark
of
colorectal
cancer
(CRC).
CRC
cells
are
geared
toward
rapid
proliferation,
requiring
nutrients
and
the
removal
cellular
waste
in
nutrient-poor
environments.
Intestinal
stem
(ISCs),
primary
cell
origin
for
CRCs,
must
adapt
their
along
adenoma-carcinoma
sequence
to
unique
features
complex
microenvironment
that
include
interactions
with
intestinal
epithelial
cells,
immune
stromal
commensal
microbes,
dietary
components.
Emerging
evidence
implicates
modifiable
risk
factors
related
environment,
such
as
diet,
important
pathogenesis.
Here,
we
focus
on
describing
ISCs,
diets
influence
initiation,
genetics
metabolism,
tumor
microenvironment.
The
mechanistic
links
between
environmental
factors,
metabolic
adaptations,
enhancing
or
supporting
tumorigenesis
becoming
better
understood.
Thus,
greater
knowledge
holds
promise
improved
prevention
treatment.
Trends in Endocrinology and Metabolism,
Journal Year:
2023,
Volume and Issue:
34(8), P. 489 - 501
Published: June 17, 2023
Cancer
remains
the
second
leading
cause
of
mortality,
with
nearly
10
million
deaths
worldwide
in
2020.
In
many
cases,
radiotherapy
is
used
for
its
anticancer
effects.
However,
radiation
causes
healthy
tissue
toxicity
as
a
side
effect.
intra-abdominal
and
pelvic
malignancies,
bowel
inevitably
included
field,
causing
radiation-induced
enteritis
dramatically
affecting
gut
microbiome.
This
condition
associated
significant
morbidity
mortality
that
impairs
cancer
patients'
survivors'
quality
life.
Review
provides
critical
overview
main
drivers
modulating
microenvironment
homeostasis,
disease,
injury,
focusing
on
microbial
metabolites
microorganisms
influence
epithelial
regeneration
upon
injury.
Experimental & Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
56(3), P. 495 - 500
Published: March 1, 2024
Abstract
The
intestinal
epithelium
is
the
first
line
of
defense
and
acts
as
an
interface
between
vast
microbial
world
within
gastrointestinal
tract
body’s
internal
milieu.
not
only
facilitates
nutrient
absorption
but
also
plays
a
key
role
in
defending
against
pathogens
regulating
immune
system.
Central
to
maintaining
healthy
are
stem
cells
(ISCs),
which
essential
for
replenishing
throughout
individual’s
lifespan.
Recent
research
has
unveiled
intricate
interplay
ISCs
their
niche,
includes
various
cell
types,
extracellular
components,
signaling
molecules.
In
this
review,
we
delve
into
most
recent
advances
ISC
research,
with
focus
on
roles
mucosal
homeostasis
how
functionality
influenced
by
niche
environment.
explored
regulatory
mechanisms
that
govern
behavior,
emphasizing
dynamic
adaptability
face
challenges.
Understanding
regulation
impact
aging
environmental
factors
crucial
advancing
our
knowledge
developing
translational
approaches.
Future
studies
should
investigate
interactive
effects
different
risk
function
develop
strategies
improving
regenerative
capacity
gut.
