Science Bulletin, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)
Опубликована: Янв. 10, 2024
The concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend modern medical advancement. Herein, we rationally designed smart molecule ER-ZS for endoplasmic reticulum (ER)-targeted diagnosis treatment in cell animal models by combining hemicyanine dyes ER-targeted functional groups (p-toluenesulfonamide). Owing to its ability target ER a highly specific response viscosity, demonstrated substantial fluorescence turn-on only after binding ER, independent other physiological environments. In addition, ER-ZS, being small molecule, allows nonalcoholic fatty liver disease (NAFLD) via imaging based on high stress. Importantly, is type I photosensitizer, producing O
Язык: Английский
Процитировано
75
ACS Nano, Год журнала: 2024, Номер 18(17), С. 10979 - 11024
Опубликована: Апрель 18, 2024
Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism action vast majority remains poorly understood. To tackle this limitation, herein, review critically discusses strategy applying multiomics analysis study nanomedicines, named nanomedomics, including advantages, applications, future directions. comprehensive understanding could provide valuable insight therefore foster development translation nanomedicines.
Язык: Английский
Процитировано
36
ACS Nano, Год журнала: 2024, Номер 18(20), С. 12830 - 12844
Опубликована: Май 6, 2024
The immunosuppressive microenvironment of cervical cancer significantly hampers the effectiveness immunotherapy. Herein, PEGylated manganese-doped calcium sulfide nanoparticles (MCSP) were developed to effectively enhance antitumor immune response through gas-amplified metalloimmunotherapy with dual activation pyroptosis and STING pathway. bioactive MCSP exhibited ability rapidly release Ca2+, Mn2+, H2S in tumor microenvironment. disrupted buffer system cells by interfering oxidative phosphorylation pathway, leading overload-triggered pyroptosis. On other hand, H2S-mediated mitochondrial dysfunction further promoted DNA (mtDNA), enhancing effect Mn2+ on cGAS-STING signaling axis thereby activating immunosuppressed dendritic cells. released acted as an important synergist between Ca2+ modulating mechanisms bridge innate adaptive responses. combination NPs PD-1 immunotherapy achieved synergistic effects inhibited growth. This study reveals potential collaboration gas therapy provides idea for design nanoimmunomodulators rational regulation
Язык: Английский
Процитировано
31
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Март 7, 2025
Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both onset progression of various diseases. Under physiological conditions, oxidative free radicals generated by mitochondrial respiratory chain, endoplasmic reticulum, NADPH oxidases can be effectively neutralized NRF2-mediated antioxidant responses. These responses elevate synthesis superoxide dismutase (SOD), catalase, well key molecules like nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH), thereby maintaining cellular redox homeostasis. Disruption this finely tuned equilibrium is closely linked to pathogenesis wide range Recent advances have broadened our understanding molecular mechanisms underpinning dysregulation, highlighting pivotal roles genomic instability, epigenetic modifications, protein degradation, metabolic reprogramming. findings provide foundation for exploring regulation mechanistic basis improving therapeutic strategies. While antioxidant-based therapies shown early promise conditions where stress plays primary pathological role, efficacy diseases characterized complex, multifactorial etiologies remains controversial. A deeper, context-specific signaling, particularly redox-sensitive proteins, designing targeted aimed at re-establishing balance. Emerging small molecule inhibitors that target specific cysteine residues proteins demonstrated promising preclinical outcomes, setting stage forthcoming clinical trials. In review, we summarize current intricate relationship disease also discuss how these insights leveraged optimize strategies practice.
Язык: Английский
Процитировано
11
Advanced Science, Год журнала: 2023, Номер 11(7)
Опубликована: Дек. 8, 2023
Abstract Endogenous essential metal ions play an important role in many life processes, especially tumor development and immune response. The approval of various metallodrugs for therapy brings more attention to the antitumor effect ions. With deepening understanding regulation mechanisms ion homeostasis vivo, breaking intracellular becomes a new means inhibit proliferation cells activate Diverse nanomedicines with loading small molecular regulators or have been developed disrupt cells, higher safety efficiency than free compounds. This comprehensive review focuses on latest progress regulation‐based including calcium (Ca 2+ ), ferrous (Fe cuprous (Cu + managanese (Mn zinc (Zn ). physiological functions processes are summarized guide design nanomedicines. Then ions‐based some efficient synergistic therapies highlighted. Finally, challenges future developments also discussed, hoping provide reference finding effective therapies.
Язык: Английский
Процитировано
39
Water Research, Год журнала: 2024, Номер 255, С. 121465 - 121465
Опубликована: Март 13, 2024
Язык: Английский
Процитировано
14
Neural Regeneration Research, Год журнала: 2024, Номер 19(12), С. 2684 - 2697
Опубликована: Янв. 31, 2024
Na + /K -ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three out and two K into cells. Additionally, participates Ca 2+ -signaling transduction neurotransmitter release coordinating ion concentration gradient membrane. works synergistically with multiple channels membrane to form dynamic network homeostatic regulation affects cellular communication regulating chemical signals balance among different types Therefore, it not surprising dysfunction emerged as risk factor for variety neurological diseases. However, published studies have so far only elucidated disease development, we are lacking detailed mechanisms clarify how function. Our recent revealed loss key mechanism many disorders, particularly stroke Parkinson’s disease. Stabilization plasma an antibody novel strategy treat these For this reason, acts simple pump but also sensor/regulator or cytoprotective protein, participating signal such neuronal autophagy apoptosis, glial migration. Thus, present review attempts summarize biological functions -ATPase-related pathogenesis. The potential strategies brain diseases will be discussed.
Язык: Английский
Процитировано
11
Cancer Cell International, Год журнала: 2024, Номер 24(1)
Опубликована: Апрель 15, 2024
Abstract Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although have been previously assumed to constitute a class of RNA transcripts without coding capacity. Furthermore, recent studies revealed ncRNA-derived micropeptides exhibit regulatory functions in the development many tumours. Although some these inhibit tumour growth, others promote it. Understanding role ncRNA-encoded cancer poses new challenges for research, but also offers promising prospects therapy. In this review, we summarize types ncRNAs encode highlighting technical developments made it easier research such as ribosome analysis, mass spectrometry, bioinformatics methods, and CRISPR/Cas9. based on distribution different subcellular locations, explain biological human cancers discuss their underestimated potential diagnostic biomarkers anticancer therapeutic targets clinical applications, information may contribute discovery micropeptide-based tools early diagnosis drug development.
Язык: Английский
Процитировано
11
Journal of Controlled Release, Год журнала: 2024, Номер 370, С. 14 - 42
Опубликована: Апрель 17, 2024
Язык: Английский
Процитировано
11
Advanced Materials, Год журнала: 2024, Номер 36(15)
Опубликована: Янв. 8, 2024
Abstract Tumor calcification is found to be associated with the benign prognostic, and which shows considerable promise as a somewhat predictive index of tumor response clinically. However, still missing area in clinical cancer treatment. A specific strategy proposed for inducing through synergy calcium peroxide (CaO 2 )‐based microspheres transcatheter arterial embolization treatment hepatocellular carcinoma (HCC). The persistent stress situ specifically leads powerful calcioptosis, resulting diffuse high‐density shadow on computed tomography that enables clear localization vivo site partial delineation margins an orthotopic HCC rabbit model. This osmotic can facilitate diagnosis, great significance differentiating during early follow‐up periods. Proteome phosphoproteome analysis identify calreticulin (CALR) crucial target protein involved calcioptosis. Further fluorescence molecular imaging also indicates CALR used prodromal marker predict at earlier stage different preclinical rodent models. These findings suggest upregulated association calcification, may broadly useful quick visualization response.
Язык: Английский
Процитировано
10