Chronic inflammation and the hallmarks of aging

Molecular Metabolism, Год журнала: 2023, Номер 74, С. 101755 - 101755

Опубликована: Июнь 16, 2023

Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.

Язык: Английский

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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Biogerontology, Год журнала: 2023, Номер 24(5), С. 609 - 662

Опубликована: Июль 30, 2023

Язык: Английский

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The multi-faceted nature of age-associated osteoporosis

Bone Reports, Год журнала: 2024, Номер 20, С. 101750 - 101750

Опубликована: Март 1, 2024

Age-associated osteoporosis (AAOP) poses a significant health burden, characterized by increased fracture risk due to declining bone mass and strength. Effective prevention early treatment strategies are crucial mitigate the disease burden associated healthcare costs. Current therapeutic approaches effectively target individual contributing factors AAOP. Nonetheless, management of AAOP is complicated multitude variables that affect its development. Main intrinsic extrinsic reviewed here, including mechanical unloading, nutrient deficiency, hormonal disbalance, disrupted metabolism, cognitive decline, inflammation circadian disruption. Furthermore, it discussed how these can be targeted for treatment. Although valuable as targets intervention, interconnectedness result in unique etiology every patient. Acknowledgement multifaceted nature will enable development more effective sustainable strategies, based on holistic, patient-centered approach.

Язык: Английский

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The Involvement of Antioxidants in Cognitive Decline and Neurodegeneration: Mens Sana in Corpore Sano

Antioxidants, Год журнала: 2024, Номер 13(6), С. 701 - 701

Опубликована: Июнь 7, 2024

With neurodegenerative disorders being on the rise, a great deal of research from multiple fields is conducted in order to further knowledge and propose novel therapeutic interventions. Among these investigations, role antioxidants contrasting cognitive decline putting forward interesting promising results. In this review, we aim collect evidence that focused variety antioxidant-rich foods improving or stabilizing functions, memory, Alzheimer’s disease, most common disorder. Specifically, considered collected humans, either through longitudinal studies randomized, placebo-controlled ones, which evaluated performance, memory abilities, progression level neurodegeneration. Overall, despite between study protocols, cohorts participants involved, neuropsychological tests used, investigated antioxidants, there solid trend suggests properties may be helpful hampering older people. Thus, help future will elucidate neuroprotection lead development interventions take into account such findings provide more global approach treating disorders.

Язык: Английский

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Metabolic remodeling in cancer and senescence and its therapeutic implications

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер 35(8), С. 732 - 744

Опубликована: Март 6, 2024

Язык: Английский

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Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 7, 2024

SUMMARY Health is strongly affected by aging and lifespan-modulating interventions, but the molecular mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq analysis mice subjected to 20 compound treatments in Interventions Testing Program (ITP). By integrating it with data from over 4,000 rodent tissues representing responses genetic, pharmacological, dietary interventions established survival data, developed robust multi-tissue transcriptomic biomarkers mortality, capable quantifying change lifespan both short-lived long-lived models. These tools were further extended single-cell human demonstrating common across cell types species. Via a network analysis, identified annotated 26 co-regulated modules longevity tissues, interpretable module-specific clocks that capture aging- mortality-associated phenotypes functional components, including, among others, inflammatory response, mitochondrial function, lipid metabolism, extracellular matrix organization. captured characterized acceleration biological age induced progeria models chronic diseases rodents humans. They also revealed rejuvenation heterochronic parabiosis, early embryogenesis, cellular reprogramming, highlighting universal signatures shared age-related disease. included Cdkn1a Lgals3 , whose plasma levels demonstrated strong association all-cause disease incidence risk factors, such as obesity hypertension. Overall, this study uncovers hallmarks mammalian organs, types, species rejuvenation, exposing fundamental longevity.

Язык: Английский

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The brain–body energy conservation model of aging

Nature Aging, Год журнала: 2024, Номер 4(10), С. 1354 - 1371

Опубликована: Окт. 8, 2024

Язык: Английский

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Anti-hepatopathy and anti-nephropathy activities of Taraxacum officinale in a rat model of Streptozotocin diabetes-induced hepatorenal toxicity and dyslipidemia via attenuation of oxidative stress, inflammation, apoptosis, electrolyte imbalances, and mitochondrial dysfunction

Aspects of Molecular Medicine, Год журнала: 2024, Номер 3, С. 100034 - 100034

Опубликована: Фев. 15, 2024

Diabetes and chronic liver kidney disease are common long-term conditions worldwide. Taraxacum officinale (TOE) has many medicinal properties, due to it phytochemicals constitutions. This study investigate activities of TOE in Streptozotocin diabetes-Induced Hepatorenal toxicity. Sixty rats were randomized into groups A, B, C, D, E, F ten each (n = 10). Group normal control, group B treated with TOE, C diabetic (DM) negative D DM E metformin (MF)], follow by STZ-diabetic). Serum lipid profile, alanine transaminase (ALT), aspartate (AST), alkaline phosphatase (ALP), Gamma-glutamyl transferase (GGT), total proteins (TP), albumin (ALB), Urea, creatinine, electrolyte, oxidative antioxidant enzymes, caspase 3, inflammatory cytokines, tricarboxylic acid (TCA) cycle enzymes mitochondrial membrane potential (ΔΨm), histology investigated. Treatment ameliorated all the electrolyte disruptions rats. + MF recovered makers, Moreover, an increase hepatic renal functional markers, ALT, AST, ALP, GGT, TP, ALB, TCA respiratory-chain complexes (I-IV) ΔΨm a decrease creatinine clearance was treatment. protected against histological damage group. toxicity effectively administration. might be considered as protective agent hepatorenal

Язык: Английский

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Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4482 - 4482

Опубликована: Апрель 19, 2024

Lifespan is a complex quantitative trait involving genetic and non-genetic factors as well the peculiarities of ontogenesis. As with all traits, lifespan shows considerable variation within populations between individuals. Drosophila, favourite object geneticists, has greatly advanced our understanding how different forms variability affect lifespan. This review considers role heritable variability, phenotypic plasticity stochastic in controlling Drosophila melanogaster. We discuss major historical milestones development approach to study lifespan, breeding long-lived lines, advances QTL mapping, environmental that have greatest influence on laboratory maintained flies, mechanisms, by which individual affects longevity. The interplay approaches ageing limitation will also be discussed. Particular attention paid interaction types control

Язык: Английский

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Boosting Cellular Longevity Through Intracellular ATP Modulation

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Abstract Aging results from the gradual accumulation of molecular damage as a result cellular processes and is characterized by impaired functions, most notably an age-related decline in ATP production. However, causal relationship between homeostasis aging has not been established. In this study, we employed nucleotide transporter eukaryotic intracellular parasite to directly alter levels budding yeast cells exchange it with extracellular milieu. We found that depletion significantly shortens lifespan, whereas supplementation medium fully restores it. Analysis gene expression showed inhibition catabolic suggesting increased suppresses glucose metabolism. Our also leads lifespan extension. Overall, our study revealed direct impact on regulation lifespan. This work offers new insights into bioenergetic control positions energy metabolism promising target for longevity interventions.

Язык: Английский

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