Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101755 - 101755
Published: June 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Bone Reports,
Journal Year:
2024,
Volume and Issue:
20, P. 101750 - 101750
Published: March 1, 2024
Age-associated
osteoporosis
(AAOP)
poses
a
significant
health
burden,
characterized
by
increased
fracture
risk
due
to
declining
bone
mass
and
strength.
Effective
prevention
early
treatment
strategies
are
crucial
mitigate
the
disease
burden
associated
healthcare
costs.
Current
therapeutic
approaches
effectively
target
individual
contributing
factors
AAOP.
Nonetheless,
management
of
AAOP
is
complicated
multitude
variables
that
affect
its
development.
Main
intrinsic
extrinsic
reviewed
here,
including
mechanical
unloading,
nutrient
deficiency,
hormonal
disbalance,
disrupted
metabolism,
cognitive
decline,
inflammation
circadian
disruption.
Furthermore,
it
discussed
how
these
can
be
targeted
for
treatment.
Although
valuable
as
targets
intervention,
interconnectedness
result
in
unique
etiology
every
patient.
Acknowledgement
multifaceted
nature
will
enable
development
more
effective
sustainable
strategies,
based
on
holistic,
patient-centered
approach.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(6), P. 701 - 701
Published: June 7, 2024
With
neurodegenerative
disorders
being
on
the
rise,
a
great
deal
of
research
from
multiple
fields
is
conducted
in
order
to
further
knowledge
and
propose
novel
therapeutic
interventions.
Among
these
investigations,
role
antioxidants
contrasting
cognitive
decline
putting
forward
interesting
promising
results.
In
this
review,
we
aim
collect
evidence
that
focused
variety
antioxidant-rich
foods
improving
or
stabilizing
functions,
memory,
Alzheimer’s
disease,
most
common
disorder.
Specifically,
considered
collected
humans,
either
through
longitudinal
studies
randomized,
placebo-controlled
ones,
which
evaluated
performance,
memory
abilities,
progression
level
neurodegeneration.
Overall,
despite
between
study
protocols,
cohorts
participants
involved,
neuropsychological
tests
used,
investigated
antioxidants,
there
solid
trend
suggests
properties
may
be
helpful
hampering
older
people.
Thus,
help
future
will
elucidate
neuroprotection
lead
development
interventions
take
into
account
such
findings
provide
more
global
approach
treating
disorders.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 7, 2024
SUMMARY
Health
is
strongly
affected
by
aging
and
lifespan-modulating
interventions,
but
the
molecular
mechanisms
of
mortality
regulation
remain
unclear.
Here,
we
conducted
an
RNA-seq
analysis
mice
subjected
to
20
compound
treatments
in
Interventions
Testing
Program
(ITP).
By
integrating
it
with
data
from
over
4,000
rodent
tissues
representing
responses
genetic,
pharmacological,
dietary
interventions
established
survival
data,
developed
robust
multi-tissue
transcriptomic
biomarkers
mortality,
capable
quantifying
change
lifespan
both
short-lived
long-lived
models.
These
tools
were
further
extended
single-cell
human
demonstrating
common
across
cell
types
species.
Via
a
network
analysis,
identified
annotated
26
co-regulated
modules
longevity
tissues,
interpretable
module-specific
clocks
that
capture
aging-
mortality-associated
phenotypes
functional
components,
including,
among
others,
inflammatory
response,
mitochondrial
function,
lipid
metabolism,
extracellular
matrix
organization.
captured
characterized
acceleration
biological
age
induced
progeria
models
chronic
diseases
rodents
humans.
They
also
revealed
rejuvenation
heterochronic
parabiosis,
early
embryogenesis,
cellular
reprogramming,
highlighting
universal
signatures
shared
age-related
disease.
included
Cdkn1a
Lgals3
,
whose
plasma
levels
demonstrated
strong
association
all-cause
disease
incidence
risk
factors,
such
as
obesity
hypertension.
Overall,
this
study
uncovers
hallmarks
mammalian
organs,
types,
species
rejuvenation,
exposing
fundamental
longevity.
Aspects of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
3, P. 100034 - 100034
Published: Feb. 15, 2024
Diabetes
and
chronic
liver
kidney
disease
are
common
long-term
conditions
worldwide.
Taraxacum
officinale
(TOE)
has
many
medicinal
properties,
due
to
it
phytochemicals
constitutions.
This
study
investigate
activities
of
TOE
in
Streptozotocin
diabetes-Induced
Hepatorenal
toxicity.
Sixty
rats
were
randomized
into
groups
A,
B,
C,
D,
E,
F
ten
each
(n
=
10).
Group
normal
control,
group
B
treated
with
TOE,
C
diabetic
(DM)
negative
D
DM
E
metformin
(MF)],
follow
by
STZ-diabetic).
Serum
lipid
profile,
alanine
transaminase
(ALT),
aspartate
(AST),
alkaline
phosphatase
(ALP),
Gamma-glutamyl
transferase
(GGT),
total
proteins
(TP),
albumin
(ALB),
Urea,
creatinine,
electrolyte,
oxidative
antioxidant
enzymes,
caspase
3,
inflammatory
cytokines,
tricarboxylic
acid
(TCA)
cycle
enzymes
mitochondrial
membrane
potential
(ΔΨm),
histology
investigated.
Treatment
ameliorated
all
the
electrolyte
disruptions
rats.
+
MF
recovered
makers,
Moreover,
an
increase
hepatic
renal
functional
markers,
ALT,
AST,
ALP,
GGT,
TP,
ALB,
TCA
respiratory-chain
complexes
(I-IV)
ΔΨm
a
decrease
creatinine
clearance
was
treatment.
protected
against
histological
damage
group.
toxicity
effectively
administration.
might
be
considered
as
protective
agent
hepatorenal
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4482 - 4482
Published: April 19, 2024
Lifespan
is
a
complex
quantitative
trait
involving
genetic
and
non-genetic
factors
as
well
the
peculiarities
of
ontogenesis.
As
with
all
traits,
lifespan
shows
considerable
variation
within
populations
between
individuals.
Drosophila,
favourite
object
geneticists,
has
greatly
advanced
our
understanding
how
different
forms
variability
affect
lifespan.
This
review
considers
role
heritable
variability,
phenotypic
plasticity
stochastic
in
controlling
Drosophila
melanogaster.
We
discuss
major
historical
milestones
development
approach
to
study
lifespan,
breeding
long-lived
lines,
advances
QTL
mapping,
environmental
that
have
greatest
influence
on
laboratory
maintained
flies,
mechanisms,
by
which
individual
affects
longevity.
The
interplay
approaches
ageing
limitation
will
also
be
discussed.
Particular
attention
paid
interaction
types
control
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Abstract
Aging
results
from
the
gradual
accumulation
of
molecular
damage
as
a
result
cellular
processes
and
is
characterized
by
impaired
functions,
most
notably
an
age-related
decline
in
ATP
production.
However,
causal
relationship
between
homeostasis
aging
has
not
been
established.
In
this
study,
we
employed
nucleotide
transporter
eukaryotic
intracellular
parasite
to
directly
alter
levels
budding
yeast
cells
exchange
it
with
extracellular
milieu.
We
found
that
depletion
significantly
shortens
lifespan,
whereas
supplementation
medium
fully
restores
it.
Analysis
gene
expression
showed
inhibition
catabolic
suggesting
increased
suppresses
glucose
metabolism.
Our
also
leads
lifespan
extension.
Overall,
our
study
revealed
direct
impact
on
regulation
lifespan.
This
work
offers
new
insights
into
bioenergetic
control
positions
energy
metabolism
promising
target
for
longevity
interventions.
