Inhibition and impulsivity: Behavioral and neural basis of response control

Progress in Neurobiology, Год журнала: 2013, Номер 108, С. 44 - 79

Опубликована: Июль 13, 2013

Язык: Английский

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Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Annual Review of Psychology, Год журнала: 2015, Номер 67(1), С. 23 - 50

Опубликована: Авг. 8, 2015

A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational use to compulsive drug-seeking habits, neurally underpinned by prefrontal cortical striatal control over seeking and taking well progression the ventral dorsal striatum. Here, in light of burgeoning, supportive evidence, reconsider elaborate this hypothesis, particular refinements our understanding mechanisms underlying goal-directed habitual seeking, influence drug-associated Pavlovian-conditioned stimuli on relapse, evidence for impairments top-down inhibitory behavior. We further review animal human studies have begun define etiological factors individual differences propensity become addicted drugs, leading description endophenotypes, especially cocaine addiction. consider prospect novel treatments promote abstinence relapse use.

Язык: Английский

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Computational psychiatry as a bridge from neuroscience to clinical applications

Nature Neuroscience, Год журнала: 2016, Номер 19(3), С. 404 - 413

Опубликована: Фев. 23, 2016

Язык: Английский

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Reflecting on rumination: Consequences, causes, mechanisms and treatment of rumination

Behaviour Research and Therapy, Год журнала: 2020, Номер 127, С. 103573 - 103573

Опубликована: Янв. 31, 2020

Язык: Английский

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Characterizing a psychiatric symptom dimension related to deficits in goal-directed control

eLife, Год журнала: 2016, Номер 5

Опубликована: Фев. 15, 2016

Prominent theories suggest that compulsive behaviors, characteristic of obsessive-compulsive disorder and addiction, are driven by shared deficits in goal-directed control, which confers vulnerability for developing rigid habits. However, recent studies have shown deficient control accompanies several disorders, including those without an obvious element. Reasoning this lack clinical specificity might reflect broader issues with psychiatric diagnostic categories, we investigated whether a dimensional approach would better delineate the manifestations deficits. Using large-scale online assessment symptoms neurocognitive performance two independent general-population samples, found were most strongly associated symptom dimension comprising behavior intrusive thought. This association was highly specific when compared to other non-compulsive aspects psychopathology. These data showcase powerful new methodology highlight potential dimensional, biologically-grounded psychiatry research.

Язык: Английский

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New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

CNS Spectrums, Год журнала: 2014, Номер 19(1), С. 69 - 89

Опубликована: Фев. 1, 2014

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated risk-seeking harm-avoidance. However, they increasingly recognized to be linked shared neuropsychological mechanisms involving dysfunctional inhibition thoughts behaviors. In this article, we selectively review new developments in the investigation neurocognition humans, order advance our understanding pathophysiology impulsive, compulsive, addictive disorders indicate directions for research.

Язык: Английский

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Obesity and the brain: how convincing is the addiction model?

Nature reviews. Neuroscience, Год журнала: 2012, Номер 13(4), С. 279 - 286

Опубликована: Март 14, 2012

Язык: Английский

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Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review

Neuron, Год журнала: 2018, Номер 98(5), С. 886 - 903

Опубликована: Июнь 1, 2018

Язык: Английский

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Neuropsychosocial profiles of current and future adolescent alcohol misusers

Nature, Год журнала: 2014, Номер 512(7513), С. 185 - 189

Опубликована: Июль 1, 2014

Язык: Английский

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Canceling actions involves a race between basal ganglia pathways

Nature Neuroscience, Год журнала: 2013, Номер 16(8), С. 1118 - 1124

Опубликована: Июль 14, 2013

Язык: Английский

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