Flavonoids in mitigating the adverse effects of canine endotoxemia DOI Creative Commons
Alma Virág Móritz,

Hédi Kovács,

Ákos Jerzsele

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 13, 2024

In dogs, chronic enteropathies, and impaired gut integrity, as well microbiome imbalances, are a major problem. These conditions may represent continuous low endotoxin load, which result in the development of diseases that attributable to inflammation. Flavonoids polyphenolic plant compounds with numerous beneficial properties such antioxidant, anti-inflammatory antimicrobial effects. For our experiments, we isolated primary white blood cells (peripheral mononuclear polymorphonuclear leukocytes) from healthy dogs induced inflammation oxidative stress Escherichia coli Salmonella enterica serovar Enteritidis lipopolysaccharide (LPS). parallel, treated cell cultures various flavonoids luteolin, quercetin grape seed extract oligomeric proanthocyanidins (GSOP) alone also combination LPS treatments. Then, changes viability, reactive oxygen species (ROS) tumor necrosis factor alpha (TNF-α) levels were measured response treatment quercetin, luteolin GSOP at 25 50 μg/mL concentrations. We found ROS significantly lower groups by flavonoid same time compared LPS-treated groups, whereas TNF-α reduced only treatment. contrast, concentrations caused an increase levels, while higher significant decrease. results suggest use be helpful management intestinal barrier integrity or altered composition, mitigation inflammatory processes maintained endotoxemia. Further vitro vivo studies needed before clinical use.

Language: Английский

Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression DOI Open Access
Nidesha Randeni, Baojun Xu

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 614 - 614

Published: Jan. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Language: Английский

Citations

3
Dietary Phenolic Compounds—Wellbeing and Perspective Applications DOI Open Access
Dasha Mihaylova, Maria Dimitrova-Dimova, Aneta Popova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4769 - 4769

Published: April 27, 2024

Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits plant-based nutrition are undeniable and research on topic rising. Modern man now aware possibilities that plant can provide seeking ways benefit from it. Dietary phenolic compounds among easily accessible beneficial substances exhibit antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, anti-diabetic, anti-atherogenic, antiproliferative, as well cardio-and neuroprotective activities. Several industries exploring incorporate biologically active their produce. This review concentrated presenting current information about dietary contribution maintaining good health. Additionally, this content will demonstrate importance prosperity natural for fields, i.e., food industry, cosmetology, biotechnology, others.

Language: Английский

Citations

13
Different polysaccharide-enhanced probiotic and polyphenol dual-functional factor co-encapsulated microcapsules demonstrate acute colitis alleviation efficacy and food fortification DOI
Rui Sun,

Zhongyi Lv,

Ying Wang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 345, P. 122572 - 122572

Published: Aug. 3, 2024

Language: Английский

Citations

8
The role of gut microbiota in MP/NP-induced toxicity DOI

Yinping Pan,

Haojie Zhang, Liancai Zhu

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124742 - 124742

Published: Aug. 15, 2024

Language: Английский

Citations

7
Benefits of Monascus anka solid-state fermentation for quinoa polyphenol bioaccessibility and the anti-obesity effect linked with gut microbiota DOI
Kai Huang, Guoqiang Chu,

Pei Yang

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(4), P. 2208 - 2220

Published: Jan. 1, 2024

In our previous study, a polyphenol-utilization targeted quinoa product was developed via solid-state fermentation with Monascus anka .

Language: Английский

Citations

6
Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids DOI Creative Commons
Jiarui Li,

Jinyue Zhao,

Chuanxi Tian

et al.

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: July 18, 2024

Abstract Background Natural compounds can positively impact health, and various studies suggest that they regulate glucose‒lipid metabolism by influencing short-chain fatty acids (SCFAs). This is key to maintaining energy balance normal physiological functions in the body. review explores how SCFAs glucose lipid natural modulate these processes through SCFAs. provides a healthier approach treating disorders future. Methods article reviews relevant literature on glycolipid from PubMed Web of Science Core Collection (WoSCC). It also highlights range compounds, including polysaccharides, anthocyanins, quercetins, resveratrols, carotenoids, betaines, modulation SCFA pathway. Results enrich SCFA-producing bacteria, inhibit harmful operational taxonomic unit (OTU) abundance intestinal transport rate gut microbiota affect content intestine. However, most have been conducted animals, lack clinical trials, involve fewer target More research needed support conclusions develop interventions. Conclusions are crucial for human health produced mainly via dietary fiber fermentation. Eating foods rich fruits, vegetables, tea, coarse foods, hinder bacterial growth promote beneficial proliferation, thus increasing levels regulating metabolism. By investigating pathway, novel insights directions glucolipid be provided.

Language: Английский

Citations

6
Fractionation of phenolic compounds from hickory by-products using solid phase extraction-sonication: Chemical composition, antioxidant and antimicrobial activity DOI
Changling Wu,

Bohui Ma,

David Julian McClements

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140633 - 140633

Published: July 25, 2024

Language: Английский

Citations

5
The Legalome: Microbiology, Omics and Criminal Justice DOI Creative Commons
Alan C. Logan, Pragya Mishra, Susan L. Prescott

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(3)

Published: March 1, 2025

ABSTRACT Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles human cognition behaviour. Included this research is evidence indicating gut microbes, through direct indirect pathways, can influence aggression, anger, irritability antisocial Moreover, manufacture chemicals are known to compromise cognition. For example, recent court decisions United States Europe acknowledge produce high levels of ethanol, without consumption alcohol by defendants. The dismissal driving while intoxicated charges these cases—so‐called auto‐brewery syndrome—highlights way which microbiome knowledge will enhance precision, objectivity fairness our legal systems. Here opinion essay, we introduce concept ‘legalome’—the application science forensic psychiatry criminal law. We argue rapid pace microbial discoveries, including those challenge ideas free moral responsibility, necessitate a reconsideration traditional doctrines justifications retributive punishment. implications extend beyond courtroom, challenging us reconsider how environmental factors—from diet socioeconomic conditions—might shape preventative rehabilitative efforts their effects on microbiome.

Language: Английский

Citations

0
EGCG induced the formation of protein nanofibrils hydrogels with enhanced anti-bacterial activity DOI

Shuifang Mao,

Yujun Zeng, Yanming Ren

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 157, P. 110408 - 110408

Published: July 11, 2024

Language: Английский

Citations

4
Phenolic compounds in dietary target the regulation of gut microbiota: Role in health and disease DOI
Qinqiu Zhang, Yi Xu, Danka Bukvički

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105107 - 105107

Published: Sept. 1, 2024

Language: Английский

Citations

4