Molecules,
Год журнала:
2023,
Номер
28(17), С. 6344 - 6344
Опубликована: Авг. 30, 2023
Cadmium
(Cd),
a
harmful
heavy
metal
that
has
no
biological
purpose,
can
harm
healthy
fetal
and
child
development.
Epigallocatechin-3-gallate
(EGCG),
the
most
abundant
polyphenol
in
tea,
been
shown
to
increase
cell
viability
under
Cd
exposure
ameliorate
Cd-induced
kidney
injury
adult
male
rats.
Using
Caenorhabditis
elegans
(C.
elegans)
model,
we
demonstrated
EGCG
mitigated
body
size
developmental
toxicity
through
mechanism
did
not
involve
chelation
with
was
associated
accumulation
efflux.
Our
research
indicated
beneficial
effects
of
on
were
mitigation
endoplasmic
reticulum
stress.
Furthermore,
our
observations
indicate
reduced
C.
via
PEK-1/eIF-2α/ATF-4
pathway.
results
provide
important
evidence
for
potential
benefits
consuming
tea
as
detoxification
agent.
Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Март 19, 2022
Abstract
With
the
increase
of
human
activities,
cadmium
(Cd)
pollution
has
become
a
global
environmental
problem
affecting
biological
metabolism
in
ecosystem.
Cd
very
long
half-life
humans
and
is
excreted
slowly
organs,
which
poses
serious
threat
to
health.
In
order
better
understand
toxicity
effects
cadmium,
third
instar
larvae
Drosophila
melanogaster
(Canton-S
strain)
were
exposed
different
concentrations
(1.125
mg/kg,
2.25
4.5
9
mg/kg)
cadmium.
Trypan
blue
staining
showed
that
intestinal
cell
damage
increased
comet
assay
indicated
significantly
more
DNA
high
concentrations.
The
nitroblue
tetrazolium
(NBT)
experiments
proved
content
reactive
oxygen
species
(ROS)
increased,
exposure
could
induce
oxidative
stress.
addition,
expression
mitochondrial
adenine
nucleotide
transferase
coding
gene
(
sesB
Ant2
)
apoptosis
related
genes
Debcl,
hid,
rpr,
p53,
Sce
Diap1
changed,
may
lead
apoptosis.
These
findings
confirmed
on
stress
after
early
exposure,
providing
insights
into
understanding
heavy
metal
animal
development.
Environmental Toxicology and Chemistry,
Год журнала:
2025,
Номер
44(1), С. 294 - 301
Опубликована: Янв. 1, 2025
Whether
soil
heavy
metal
pollution
contributes
to
the
decline
in
pollinator
populations
remains
inconclusive.
Based
on
detection
of
metals
nectar,
pollen,
and
bodies
pollinating
insects
areas
affected
by
pollution,
this
study
aimed
investigate
impact
adding
four
metals-zinc
(Zn),
lead
(Pb),
copper
(Cu),
nickel
(Ni)-at
realistic
concentrations
diet
pre-oviposition
period,
larval
development
production
adult
bees,
weight
worker
bees.
The
sought
evaluate
influence
accumulation
mediated
floral
rewards
key
stages
growth
bumblebee
(Bombus
terrestris
L.).
Results
revealed
that
Zn,
Pb,
Cu
significantly
extended
period
queen
with
Pb
doubling
time
at
high
Ni
showing
no
significant
effect
moderate
low
concentrations.
Lead,
Cu,
medium
concentrations,
whereas
Zn
only
had
a
reduced
bee
yield
body
bees
different
among
which
25%-40%.
concentration
was
most
obvious,
reduction
30%.
Our
findings
support
hypothesis
rewards,
can
have
serious
some
bumblebees.
Journal of Applied Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
ABSTRACT
N
‐Nitrosodimethylamine
(NDMA)
is
a
known
water
disinfection
byproduct
(DBP)
characterized
as
potent
hepatotoxin,
promutagen,
and
probable
human
carcinogen;
this
because
of
the
metabolites
associated
with
its
biotransformation.
The
metabolism
NDMA
produces
formaldehyde,
another
alkylating
agent
DBP.
Both
compounds
are
generated
from
natural
anthropogenic
sources,
but
safety
restrictions
applied
to
do
not
extend
uses
formaldehyde.
Hence,
potential
health
ecological
risks
concern.
Due
limited
information
on
long‐term
effects
exposure
these
at
environmentally
relevant
concentrations,
work
aimed
compare
transgenerational
reproductive
developmental
toxicity
separate
exposures
or
metabolite
formaldehyde
in
Drosophila
melanogaster
over
four
generations.
parental
flies
were
fed
(1.19E−06
5
mM)
for
48
h
during
third
larval
instar.
Subsequent
offspring
(F1–F3)
grown
under
compound‐free
conditions.
In
generation,
both
modified
time
emergence
reduced
number
progenies.
NDMA,
was
lethal,
affected
fertility,
weakly
induced
malformations.
next
generations,
malformed
offspring.
Reproductive
malformations
maintained
least
three
suggesting
that
detrimental
could
unexposed
This
first
study
reporting
individual
reproduction
development
between
D.
,
highlighting
relevance
evaluating
multiple
generations
accurately
determine
environmental
pollutants.
Ecotoxicology and Environmental Safety,
Год журнала:
2022,
Номер
250, С. 114486 - 114486
Опубликована: Дек. 30, 2022
The
transgenerational
inheritance
of
phenotype
induced
by
environmental
factors
is
a
new
focus
in
epigenetic
research.
In
this
study,
Drosophila
melanogaster
(F0)
was
cultured
the
medium
containing
cadmium
(Cd,
4.5
mg/kg)
from
eggs
to
adults,
and
offspring
(F1-F4)
were
continuously
kept
standard
(without
cadmium).
analysis
showed
that
developmental
defects
on
wings
apoptosis
wing
disc
cells
(F0).
transmitted
for
at
least
four
generations
even
without
Cd
afterwards.
And
effect
mRNA
expression
development
related
genes
(shg,
omb,
F-actin,
Mekk1)
can
be
maintained
two
or
three
generations.
More
importantly,
under
stress,
post-translational
modification
(PTM)
histones
H3K4me3
third
instar
larvae
ovaries
testes
adult
flies
increased
significantly,
while
levels
H3K9me3
H3K27me3
decreased
significantly.
histone
methylation
(dSet-1,
ash1,
Lsd1)
significantly
these
changes
one
testes.
These
results
suggest
phenotypic
caused
inherited
offspring,
may
regulation
methylation.
Therefore,
adaptability
should
considered
when
evaluating
toxicity
risk
cadmium.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(31), С. 12043 - 12051
Опубликована: Июль 20, 2023
Cadmium
is
highly
toxic
and
present
in
the
environment
can
be
accumulated
among
various
levels
of
food
chain.
Both
humans
animals
are
at
risk
from
toxicity
associated
with
cadmium.
However,
neurological
endpoint
caused
by
cadmium
has
not
been
revealed.
The
aim
our
research
to
explore
potential
target
attack
when
causing
neurotoxicity.
80
male
chickens
(one
day
old,
weighing
36.49
±
2.88
g)
were
randomly
divided
into
four
groups
independently
treated
0,
35,
70,
or
140
mg/kg
CdCl2
diet
for
90
days.
result
showed
that
striatum
was
damaged
due
a
high
dose
brain,
which
characterized
degeneration
neurons
astrocyte
dysfunction.
Transcriptome
analysis
demonstrated
striatal
astrocytes
transformed
A1
state
under
exposure.
Deeper
investigation
revealed
internalization
gap
junction
protein
connexin
43
responsible
this
transformation.
Eventually,
we
conclude
internalized
anchoring,
process
accompanied
transformation
subtype.
This
study
provides
new
direction
exploring
effects
on
nervous
system
treatment
subsequent
diseases.
Journal of Neuroscience,
Год журнала:
2024,
Номер
44(23), С. e2061232024 - e2061232024
Опубликована: Май 6, 2024
Physical
exercise
is
a
robust
lifestyle
intervention
known
for
its
enhancement
of
cognitive
abilities.
Nevertheless,
the
extent
to
which
these
benefits
can
be
transmitted
across
generations
(intergenerational
inheritance
F1,
and
transgenerational
F2
beyond)
remains
topic
limited
comprehension.
We
have
already
shown
that
improvements
resulting
from
physical
inherited
parents
their
offspring,
proving
intergenerational
effects.
So,
we
set
out
explore
whether
enhancements
might
extend
transgenerationally,
impacting
generation.
In
this
study,
initially
examined
behavioral
traits
second
generation
(F2)
male
mice,
whose
grandfathers
(F0)
had
an
intervention.
Our
findings
revealed
mice
with
physically
active
grandpaternal
F0
progenitors
displayed
significantly
improved
memory
recall,
encompassing
both
spatial
non-spatial
information
when
compared
counterparts
sedentary
progenitors,
first
time
induced
enhancement.
Surprisingly,
while
(as
was
case
F1),
adult
hippocampal
neurogenesis
remained
unchanged
between
experimental
control
groups
(unlike
in
F1).
Additionally,
our
analysis
small
RNA
sequences
hippocampus
identified
35
differentially
expressed
miRNAs
linked
important
brain
function
categories.
Notably,
two
miRNAs,
miRNA-144
miRNA-298,
negative
correlation
performance.
These
highlight
enduring
transmission
associated
exercise,
even
after
generations,
suggesting
moderate
training
lasting
positive
effects,
possibly
orchestrated
by
specific
exert
influence
multiple
generations.