Effects of Long-Term Exposure to Cadmium on Development, Reproduction and Antioxidant Enzymes of Aleuroglyphus ovatus (Acari: Acaridae) DOI Creative Commons
Yu Zhang,

Wenhui Xiong,

Shan Yang

et al.

Insects, Journal Year: 2022, Volume and Issue: 13(10), P. 895 - 895

Published: Sept. 30, 2022

Grain contaminated by cadmium (Cd) has become a serious food security problem, and it is necessary to determine evaluate the toxic effect defense mechanism of long-term heavy metal pollution in grain. In order effects Cd stress on stored grain pests, Aleuroglyphus ovatus were fed with an artificial diet supplemented different concentrations (0, 5, 10, 20 mg/kg). The development, fecundity detoxification enzymes A. analyzed observed. this study, immature duration was significantly prolonged under stress. Moreover, survival female adults shortened. total number eggs laid daily per adult decreased significantly. There significant differences protein content at protonymph tritonymph stages when concentration exceeded 10 mg/kg. higher than that male adults. activity showed conditions, such as development stage, gender. These findings confirmed sensitive Cd, their offspring severely affected Therefore, good model for evaluating toxicity study provides basis enriches research mites, contributing harmonious healthy between environment human beings.

Language: Английский

Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science DOI Creative Commons
Matthew D. Rand, Jason M. Tennessen,

Trudy F. C. Mackay

et al.

Current Protocols, Journal Year: 2023, Volume and Issue: 3(8)

Published: Aug. 1, 2023

The use of Drosophila melanogaster for studies toxicology has grown considerably in the last decade. model long been appreciated as a versatile and powerful developmental biology genetics because its ease handling, short life cycle, low cost maintenance, molecular genetic accessibility, availability wide range publicly available strains data resources. These features, together with recent unique developments genomics metabolomics, make fly especially relevant timely development new approach methodologies movements toward precision toxicology. Here, we offer perspective on how flies can be leveraged to identify risk factors environmental exposures human health. First, review discuss fundamental toxicologic principles experimental design Drosophila. Next, describe quantitative systems approaches resolve architecture candidate pathways controlling susceptibility toxicants. Finally, summarize current state future promise emerging field metabolomics elaborating toxic mechanisms. © 2023 Authors. Current Protocols published by Wiley Periodicals LLC.

Language: Английский

Citations

25
Effects of heavy metal accumulation mediated by floral rewards on key stages of growth and development of bumblebees (Bombus terrestris L.) DOI Creative Commons
Lei Wu, Qi Sun,

Zhao Ji-min

et al.

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: 44(1), P. 294 - 301

Published: Jan. 1, 2025

Whether soil heavy metal pollution contributes to the decline in pollinator populations remains inconclusive. Based on detection of metals nectar, pollen, and bodies pollinating insects areas affected by pollution, this study aimed investigate impact adding four metals-zinc (Zn), lead (Pb), copper (Cu), nickel (Ni)-at realistic concentrations diet pre-oviposition period, larval development production adult bees, weight worker bees. The sought evaluate influence accumulation mediated floral rewards key stages growth bumblebee (Bombus terrestris L.). Results revealed that Zn, Pb, Cu significantly extended period queen with Pb doubling time at high Ni showing no significant effect moderate low concentrations. Lead, Cu, medium concentrations, whereas Zn only had a reduced bee yield body bees different among which 25%-40%. concentration was most obvious, reduction 30%. Our findings support hypothesis rewards, can have serious some bumblebees.

Language: Английский

Citations

1
Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster DOI Creative Commons

Oscar Eduardo Tabares‐Mosquera,

Javier Andrés Juárez‐Díaz, Rafael Camacho‐Carranza

et al.

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

ABSTRACT N ‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as potent hepatotoxin, promutagen, and probable human carcinogen; this because of the metabolites associated with its biotransformation. The metabolism NDMA produces formaldehyde, another alkylating agent DBP. Both compounds are generated from natural anthropogenic sources, but safety restrictions applied to do not extend uses formaldehyde. Hence, potential health ecological risks concern. Due limited information on long‐term effects exposure these at environmentally relevant concentrations, work aimed compare transgenerational reproductive developmental toxicity separate exposures or metabolite formaldehyde in Drosophila melanogaster over four generations. parental flies were fed (1.19E−06 5 mM) for 48 h during third larval instar. Subsequent offspring (F1–F3) grown under compound‐free conditions. In generation, both modified time emergence reduced number progenies. NDMA, was lethal, affected fertility, weakly induced malformations. next generations, malformed offspring. Reproductive malformations maintained least three suggesting that detrimental could unexposed This first study reporting individual reproduction development between D. , highlighting relevance evaluating multiple generations accurately determine environmental pollutants.

Language: Английский

Citations

1
Effects of cadmium on oxidative stress and cell apoptosis in Drosophila melanogaster larvae DOI Creative Commons

Pingping Yang,

Xingran Yang,

Liran Sun

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: March 19, 2022

Abstract With the increase of human activities, cadmium (Cd) pollution has become a global environmental problem affecting biological metabolism in ecosystem. Cd very long half-life humans and is excreted slowly organs, which poses serious threat to health. In order better understand toxicity effects cadmium, third instar larvae Drosophila melanogaster (Canton-S strain) were exposed different concentrations (1.125 mg/kg, 2.25 4.5 9 mg/kg) cadmium. Trypan blue staining showed that intestinal cell damage increased comet assay indicated significantly more DNA high concentrations. The nitroblue tetrazolium (NBT) experiments proved content reactive oxygen species (ROS) increased, exposure could induce oxidative stress. addition, expression mitochondrial adenine nucleotide transferase coding gene ( sesB Ant2 ) apoptosis related genes Debcl, hid, rpr, p53, Sce Diap1 changed, may lead apoptosis. These findings confirmed on stress after early exposure, providing insights into understanding heavy metal animal development.

Language: Английский

Citations

33
Transgenerational hormesis: What do parents sacrifice for their offspring? DOI
Evgenios Agathokleous, R. N. C. Guedes, Edward J. Calabrese

et al.

Current Opinion in Environmental Science & Health, Journal Year: 2022, Volume and Issue: 29, P. 100380 - 100380

Published: July 15, 2022

Language: Английский

Citations

27
Cadmium chloride exposure impairs the growth and behavior of Drosophila via ferroptosis DOI

Yingxia Hu,

Haijie Wu,

Chenying Lu

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 865, P. 161183 - 161183

Published: Dec. 27, 2022

Language: Английский

Citations

21
Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium DOI Creative Commons

Liran Sun,

Yun Mu,

Lu Xu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 250, P. 114486 - 114486

Published: Dec. 30, 2022

The transgenerational inheritance of phenotype induced by environmental factors is a new focus in epigenetic research. In this study, Drosophila melanogaster (F0) was cultured the medium containing cadmium (Cd, 4.5 mg/kg) from eggs to adults, and offspring (F1-F4) were continuously kept standard (without cadmium). analysis showed that developmental defects on wings apoptosis wing disc cells (F0). transmitted for at least four generations even without Cd afterwards. And effect mRNA expression development related genes (shg, omb, F-actin, Mekk1) can be maintained two or three generations. More importantly, under stress, post-translational modification (PTM) histones H3K4me3 third instar larvae ovaries testes adult flies increased significantly, while levels H3K9me3 H3K27me3 decreased significantly. histone methylation (dSet-1, ash1, Lsd1) significantly these changes one testes. These results suggest phenotypic caused inherited offspring, may regulation methylation. Therefore, adaptability should considered when evaluating toxicity risk cadmium.

Language: Английский

Citations

17
Effects of cadmium on female Drosophila melanogaster and its transgenerational inheritance effects DOI
Fu‐Sheng Wang,

Pingping Yang,

Lu Xu

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 374, P. 124076 - 124076

Published: Jan. 15, 2025

Language: Английский

Citations

0
Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster DOI Creative Commons
Yi Pan,

Ke Fan,

Linhao Zong

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117870 - 117870

Published: Feb. 1, 2025

Cadmium (Cd), a widespread and serious environmental pollutant, has recently garnered increasing scientific scrutiny due to its profound adverse effects. Although the evidence for Cd-induced reproductive toxicity is well established, it remains elusive on intricate dose-response relationship underlying molecular mechanisms, especially transgenerational in animals. Here, we employed fruit fly (Drosophila melanogaster) as model organism examine performance across five generations by parental exposure varying concentrations of Cd (5, 50, 500 μM). Firstly, our observations number eggs laid, pupae formed, adult flies emerged directly exposed generation (F0) confirmed dose-dependent decline fecundity. Transcriptome analysis revealed that, oxidative stress ion transport disruption F0 could underlie synaptic dysfunction impaired follicle cell development, impacting behavior oocyte fertility. Employing analysis, Wnt signaling pathway mTOR were identified early responses toxicity. Secondly, sustained detrimental effects observed at least two three after removal. At epigenetic level, perturb fecundity modulating Dnmt2 expression, pivotal regulator methylation processes. Moreover, despite phenotypic recovery F4, persistent changes indicate enduring toxicity, highlighting need vigilance against contamination long-term Collectively, findings enhance understanding effects, highlight further improve assessment multigenerational consequences contamination.

Language: Английский

Citations

0
Multigenerational immunotoxicity assessment: A three-generation study in Drosophila melanogaster upon developmental exposure to triclosan DOI
Sandeep Kumar, Leonard Clinton D’Souza,

Falaknaaz Shaikh

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125860 - 125860

Published: Feb. 1, 2025

Language: Английский

Citations

0