Sports Medicine and Health Science,
Год журнала:
2023,
Номер
5(4), С. 251 - 258
Опубликована: Сен. 9, 2023
Exercise
has
well-characterized
therapeutic
benefits
in
the
management
of
type
2
diabetes
mellitus
(T2DM).
Most
beneficial
effects
exercise
arise
from
impact
nuclear
factor
erythroid
related
factor-2
(Nrf2)
activation
glucose
metabolism.
Nrf2
is
an
essential
controller
cellular
anti-oxidative
capacity
and
circadian
rhythms.
The
rhythm
influenced
by
genes
on
its
expression,
where
timing
rhythmicity
signaling,
such
that
differential
physiological
effects.
evening
management,
as
lowering
blood
weight.
mechanisms
responsible
for
these
have
not
yet
been
associated
with
influence
activity.
A
better
understanding
exercise-induced
signaling
can
improve
our
appreciation
distinct
morning
exercise.
This
review
hypothesizes
morning,
when
level
already
at
high
levels,
leads
to
hyperactivation
decrease
while
evening,
levels
are
nadir
improves
lowers
increases
fatty
acid
oxidation.
Exploring
activators
rhythmic
could
also
provide
valuable
insights
into
optimal
their
application,
holding
promise
timed
treatment
diabetes.
Journal of Advanced Research,
Год журнала:
2022,
Номер
46, С. 87 - 100
Опубликована: Май 2, 2022
Lead
(Pb)
is
an
environmental
toxicant
that
poses
severe
health
risks
to
humans
and
animals,
especially
renal
disorders.
Pb-induced
nephrotoxicity
has
been
attributed
oxidative
stress,
in
which
apoptosis
autophagy
are
core
events.
Nuclear
factor
erythroid
2-related
2
(Nrf2)
acts
as
a
major
contributor
counteract
damage,
while
hyperactivation
or
depletion
of
Nrf2
pathway
can
cause
the
redox
imbalance
induce
tissue
injury.
This
study
was
performed
clarify
function
mechanism
Pb-triggered
kidney
First,
data
showed
Pb
exposure
activates
primary
rat
proximal
tubular
cells.
Next,
activation
effectively
regulated
by
pharmacological
modulation
siRNA-mediated
knockdown
vitro
vivo
assays.
Notably,
cytotoxicity,
injury
concomitant
were
improved
downregulation,
confirming
persistent
contributes
nephrotoxicity.
Additionally,
blockage
relieved
downregulation.
Mechanistically,
we
found
reduced
ubiquitination
nuclear-cytoplasmic
loss
Keap1
p62-dependent
manner.
In
conclusion,
these
findings
highlight
dark
side
potential
crosstalk
among
activation,
Journal of Controlled Release,
Год журнала:
2022,
Номер
345, С. 214 - 230
Опубликована: Март 18, 2022
Mesenchymal
stem
cell-derived
small
extracellular
vesicles
(MSC-EVs)
are
promising
nanotherapeutic
agent
for
pneumonia
(bacterial
origin,
COVID-19),
but
the
optimal
administration
route
and
potential
mechanisms
of
action
remain
poorly
understood.
This
study
compared
MSC-EVs
via
inhalation
tail
vein
injection
treatment
acute
lung
injury
(ALI)
determined
host-derived
that
may
contribute
to
therapeutic
effects
in
lipopolysaccharide
(LPS)-stimulated
RAW
264.7
cells
(macrophage
cell
line)
animal
models.
Luminex
liquid
chip
hematoxylin
eosin
(HE)
staining
revealed
that,
with
vehicle
control,
inhaled
outperformed
those
injected
vein,
by
reducing
expression
pro-inflammatory
cytokines,
increasing
anti-inflammatory
cytokine,
decreasing
pathological
scores
ALI.
MSC-EV
promoted
polarization
macrophages
towards
a
M2
phenotype
vitro
vivo
(via
inhalation).
RNA
sequencing
immune
redox
mediators,
including
TLR4,
Arg1,
HO-1,
were
associated
activity
against
ALI
mice.
Western
blotting
immunofluorescence
correlative
inflammatory
oxidative
mediators
involved
LPS-stimulated
Moreover,
variable
Nrf2
was
observed
following
models,
knockdown
attenuated
antioxidant
activities
macrophages.
Together,
these
data
suggest
as
noninvasive
strategy
attenuation
ALI,
adaptive
regulation
their
anti-oxidant
