Corneal stromal repair and regeneration

Progress in Retinal and Eye Research, Год журнала: 2022, Номер 91, С. 101090 - 101090

Опубликована: Май 29, 2022

Язык: Английский

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Molecular engineered optical probes for chemical warfare agents and their mimics: Advances, challenges and perspectives

Coordination Chemistry Reviews, Год журнала: 2022, Номер 463, С. 214527 - 214527

Опубликована: Апрель 2, 2022

Язык: Английский

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Corneal Epithelial Stem Cells–Physiology, Pathophysiology and Therapeutic Options

Cells, Год журнала: 2021, Номер 10(9), С. 2302 - 2302

Опубликована: Сен. 3, 2021

In the human cornea, regeneration of epithelium is regulated by stem cell reservoir limbus, which marginal region cornea representing anatomical and functional border between corneal conjunctival epithelium. support this concept, extensive limbal damage, e.g., chemical or thermal injury, inflammation, surgery, may induce deficiency (LSCD) leading to vascularization opacification eventually vision loss. These acquired forms occur uni- bilaterally, important for choice treatment. Moreover, a variety inherited diseases, such as congenital aniridia dyskeratosis congenita, are characterized LSCD typically occurring bilaterally. Several techniques autologous allogenic transplantation have been established. The limbus can be restored whole grafts, small biopsies ex vivo-expanded cells. review, physiology epithelium, pathophysiology LSCD, therapeutic options will presented.

Язык: Английский

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Ultrafast Degradation and High Adsorption Capability of a Sulfur Mustard Simulant under Ambient Conditions Using Granular UiO-66-NH₂ Metal–Organic Gels

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(20), С. 23383 - 23391

Опубликована: Май 12, 2022

Zirconium-based metal–organic frameworks (Zr-MOFs) have been considered as prospective materials for the degradation of nerve chemical warfare agents (CWAs) but show poor catalytic performance toward blister agents. Moreover, powder issues and adsorption capability also remain major challenges application Zr-MOFs in practical CWA detoxification. Herein, a series defected granular UiO-66-NH2 gels are synthesized via adjusting amount added concentrated hydrochloric acid decontamination 2-chloroethyl ethyl sulfide (2-CEES), sulfur mustard simulant. The half-life 2-CEES decontaminated by can be shortened to 7.6 min, which is highest reported value MOFs under ambient conditions. mechanism that amino group on linkers MOGs undergoes substitution reaction with yield 2-(2-(ethylthio)ethylamino)terephthalic acid, less toxic fixed frameworks. recycling test corroborates xerogels possess good stability reusability. Static desorption tests high vapor capacity 802 mg/g after exposure 1 d only 28 wt % air 7 d. dual function ultrafast provide firm foundation using future protection media.

Язык: Английский

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Autophagy in Extracellular Matrix and Wound Healing Modulation in the Cornea

Biomedicines, Год журнала: 2022, Номер 10(2), С. 339 - 339

Опубликована: Фев. 1, 2022

Autophagy is a robust cellular mechanism for disposing of harmful molecules or recycling them to cells, which also regulates physiopathological processes in cornea. Dysregulated autophagy causes inefficient clearance unwanted proteins and debris, mitochondrial disorganization, defective inflammation, organ dysfunctions, cell death, diseases. The cornea accounts two-thirds the refraction light that occurs eyes, but prone trauma/injury infection. extracellular matrix (ECM) noncellular dynamic macromolecular network corneal tissues comprised collagens, proteoglycans, elastin, fibronectin, laminins, hyaluronan, glycoproteins. ECM undergoes remodeling by matrix-degrading enzymes maintains transparency. plays an important role wound healing maintenance. Delayed/dysregulated impacts healing, can lead dysfunction. Stromal involves responses from epithelium, basement membrane, keratocytes, ECM, many cytokines chemokines, including transforming growth factor beta-1 platelet-derived factor. Mild injuries self-repair, greater haze/scars/fibrosis vision loss due disruptions autophagy, normal processes. Presently, precise elusive. This review discusses recent trends modulation context homeostasis.

Язык: Английский

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Dexamethasone sodium phosphate loaded nanoparticles for prevention of nitrogen mustard induced corneal injury

Experimental Eye Research, Год журнала: 2024, Номер 243, С. 109902 - 109902

Опубликована: Апрель 18, 2024

Язык: Английский

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A novel therapy to ameliorate nitrogen mustard-induced limbal stem cell deficiency using lipoprotein-like nanoparticles

npj Regenerative Medicine, Год журнала: 2025, Номер 10(1)

Опубликована: Март 20, 2025

Chronic corneal inflammation, a component of sulfur mustard (SM) and nitrogen (NM) injuries frequently leads to limbal stem cell deficiency (LSCD), which can compromise vision. Corneal conjunctivalization, neovascularization, persistent inflammation are hallmarks LSCD. Ocular exposure SM NM results in an acute delayed phase disruption, culminating Available therapies for keratopathy (e.g., topical corticosteroids) often have adverse side effects, generally ineffective preventing the development We developed novel, optically transparent HDL nanoparticle (NP) with organic core (oc) molecular scaffold. This unique oc-HDL NP: (i) markedly improved haze during phases vivo; (ii) significantly reduced inflammatory response; (iii) blunted conjunctivalization neovascularization phase. These findings strongly suggest that our NP is ideal treatment other chronic diseases.

Язык: Английский

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Zr-MOF Crosslinked Hydrogel for High-Efficiency Decontamination of Chemical Warfare Agent Simulant

Processes, Год журнала: 2025, Номер 13(4), С. 973 - 973

Опубликована: Март 25, 2025

The decontamination of chemical warfare agents (CWAs) from contaminated surfaces is critical importance due to the severe threats posed by CWAs human health and environment, particularly given persistent threat weapons since World War I. In this study, a novel UiO-66-NH2 crosslinked hyaluronic acid (HA) hydrogel was developed in presence polyvinyl alcohol under ambient conditions, leveraging dual functionality amino-substituted zirconium-based metal–organic framework (Zr-MOF) as both crosslinker catalytic site. demonstrated exceptional performance, achieving degradation efficiency over 90% for agent simulant dimethyl 4-nitrophenyl phosphate (DMNP) within 1 h. Furthermore, adequate mechanical tensile strength practical use, enabling easy peel-off various without leaving residues. This peelable property, combined with its capabilities, highlights significant potential applications field CWA decontamination.

Язык: Английский

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Differential gene expression and protein-protein interaction network profiling of sulfur mustard-exposed rabbit corneas employing RNA-seq data and bioinformatics tools

Experimental Eye Research, Год журнала: 2023, Номер 235, С. 109644 - 109644

Опубликована: Сен. 7, 2023

Язык: Английский

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Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard

Experimental Eye Research, Год журнала: 2023, Номер 236, С. 109657 - 109657

Опубликована: Сен. 16, 2023

Язык: Английский

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