Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant DOI Creative Commons
Natasha N. Gaudreault, Konner Cool, Jessie D. Trujillo

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Ноя. 17, 2021

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that has had significant impacts on human health and economies worldwide. SARS-CoV-2 highly transmissible the cause of disease 2019 (COVID-19) in humans. A wide range animal species have also been shown to be susceptible infection by experimental and/or natural infections. Domestic large cats, mink, ferrets, hamsters, deer mice, white-tailed deer, non-human primates susceptible, whereas other such as dogs, pigs, cattle appear refractory or very limited susceptibility. Sheep ( Ovis aries ) are commonly farmed domestic ruminant not previously thoroughly investigated their susceptibility SARS-CoV-2. Therefore, we performed vitro vivo studies which consisted ruminant-derived cell cultures challenge sheep investigate Our results showed sheep-derived support replication. Furthermore, demonstrated with viral RNA shed nasal oral swabs primarily at 1-day post (DPC), detected tract lymphoid tissues 4 8 DPC. Sero-reactivity was observed some principal infected but contact sentinels, indicating transmission co-mingled naïve efficient; however, sentinel animals 21 used inoculum consisting mixture two isolates, representatives ancestral lineage B.1.1.7-like alpha variant concern (VOC), study competition virus strains. indicate show low infection, VOC outcompeted strain.

Язык: Английский

After 2 years of the COVID-19 pandemic, translating One Health into action is urgent DOI Creative Commons
Thierry Lefrançois, Denis Malvy, Laëtitia Atlani-Duault

и другие.

The Lancet, Год журнала: 2022, Номер 401(10378), С. 789 - 794

Опубликована: Окт. 24, 2022

Язык: Английский

Процитировано

71
Role of Spillover and Spillback in SARS-CoV-2 Transmission and the Importance of One Health in Understanding the Dynamics of the COVID-19 Pandemic DOI
McKenzie N. Sparrer, Natasha F. Hodges, Tyler Sherman

и другие.

Journal of Clinical Microbiology, Год журнала: 2023, Номер 61(7)

Опубликована: Апрель 26, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is notable both for its impact on global public health as well well-publicized transmissibility to other species of animals. Infection incidental animal hosts concerning because possible emergence novel variants due viral mutation. Species that are susceptible SARS-CoV-2 include domestic and nondomestic cats, dogs, white-tailed deer, mink, golden hamsters, among others. We detail origins transmission humans, the ecological molecular mechanisms needed virus establish infection in humans from highlight examples spillover, spillback, secondary demonstrating breadth variability current events have been documented domestic, captive, wild Lastly, we turn our focus importance potential reservoirs sources variant can profound effects human population. note a One Health approach emphasizing surveillance animals certain environments using interdisciplinary collaboration encouraged manage disease surveillance, regulation trade testing, vaccine development will mitigate further outbreaks. These efforts minimize spread advance knowledge prevent future emerging infectious diseases.

Язык: Английский

Процитировано

24
Understanding the prevalence of SARS-CoV-2 (COVID-19) exposure in companion, captive, wild, and farmed animals DOI Creative Commons
Hannah Murphy, Hinh Ly

Virulence, Год журнала: 2021, Номер 12(1), С. 2777 - 2786

Опубликована: Окт. 26, 2021

Several animal species, including ferrets, hamsters, monkeys, and raccoon dogs, have been shown to be susceptible experimental infection by the human severe acute respiratory syndrome coronaviruses, such as SARS-CoV SARS-CoV-2, which were responsible for 2003 SARS outbreak 2019 coronavirus disease (COVID-19) pandemic, respectively. Emerging studies that SARS-CoV-2 natural of pet dogs cats is also possible, but its prevalence not fully understood. Experimentally, it has demonstrated replicates more efficiently in than can transmit virus through aerosols. With approximately 470 million 370 cohabitating with their owners worldwide, finding these household pets important implications potential zoonotic transmission events during COVID-19 pandemic well future SARS-related outbreaks. Here, we describe some ongoing worldwide surveillance efforts assess exposure companion, captive, wild, farmed animals, provide perspectives on intra- inter-species transmissions, evolution, human-animal interface along public health. Some develop implement a new vaccine animals are discussed. Surveillance initiatives track exposures necessary accurately determine impact veterinary health, define reservoir sources evolutionary dynamics.

Язык: Английский

Процитировано

45
Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant DOI Creative Commons
Natasha N. Gaudreault, Konner Cool, Jessie D. Trujillo

и другие.

Emerging Microbes & Infections, Год журнала: 2022, Номер 11(1), С. 662 - 675

Опубликована: Фев. 2, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that has had significant impacts on human health and economies worldwide. SARS-CoV-2 highly transmissible the cause of disease 2019 in humans. A wide range animal species have also been shown to be susceptible by experimental and/or natural infections. Sheep are commonly farmed domestic ruminant not thoroughly investigated their susceptibility SARS-CoV-2. Therefore, we performed vitro vivo studies which consisted infection ruminant-derived cells challenge sheep investigate Our results showed sheep-derived kidney support replication. Furthermore, demonstrated limited with viral RNA shed nasal oral swabs at 1 3-days post (DPC); was detected tract lymphoid tissues 4 8 DPC. Sero-reactivity observed some principal infected but contact sentinels, indicating transmission co-mingled naïve efficient; however, sentinel animals 21 used inoculum consisting mixture two isolates, representatives ancestral lineage B.1.1.7-like alpha variant concern, study competition virus strains. indicate show low outcompeted strain.

Язык: Английский

Процитировано

30
An updated review of the scientific literature on the origin of SARS-CoV-2 DOI Open Access
José L. Domingo

Environmental Research, Год журнала: 2022, Номер 215, С. 114131 - 114131

Опубликована: Авг. 28, 2022

Язык: Английский

Процитировано

24
The reverse zoonotic potential of SARS-CoV-2 DOI Creative Commons
Krista M. Milich, Stephen S. Morse

Heliyon, Год журнала: 2024, Номер 10(12), С. e33040 - e33040

Опубликована: Июнь 1, 2024

There has been considerable emphasis recently on the zoonotic origins of emerging infectious diseases in humans, including SARS-CoV-2 pandemic; however, reverse zoonoses (infections transmitted from humans to other animals) have received less attention despite their potential importance. The effects can be devastating for infected species and also result transmission pathogen back human populations or animals either original form as a variant. Humans animals, virus is able circulate evolve those species. As global travel resumes, zoonosis threatens endangered Nonhuman primates are particular concern given susceptibility respiratory infections. Enforcing safety measures all people working visiting wildlife areas, especially with nonhuman primates, increasing access living near protected areas that home will help mitigate transmission.

Язык: Английский

Процитировано

5
Organoid Models of SARS-CoV-2 Infection: What Have We Learned about COVID-19? DOI Creative Commons
Bang M. Tran, Georgia Deliyannis, Abderrahman Hachani

и другие.

Organoids, Год журнала: 2022, Номер 1(1), С. 2 - 27

Опубликована: Март 2, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (COVID-19), which was classified as a pandemic in March 2020. As of 22 January 2022, globally more than 347 million cases COVID-19 have been diagnosed, with 5.6 deaths, making it the deadliest since influenza 1918. The clinical presentation COVID-19-related illness spans from asymptomatic to mild symptoms akin infection symptoms, including pneumonia necessitating hospitalisation and admission intensive care units. starts upper tract lungs but severe can also involve heart, blood vessels, brain, liver, kidneys intestine. increasing global health economic burden necessitates an urgent response. Understanding functional characteristics cellular tropism SARS-CoV-2, pathogenesis that leads multi-organ failure death, has prompted unprecedented adoption organoid models. Successful drug discovery vaccine development rely on pre-clinical models faithfully recapitulate viral life cycle host cell response infection. Human stem cell-derived organoids fulfill these criteria. Here we highlight role study SARS-CoV-2 modelling pathogenesis.

Язык: Английский

Процитировано

20
Interspecies transmission of SARS CoV-2 with special emphasis on viral mutations and ACE-2 receptor homology roles DOI Creative Commons
Mervat E. Hamdy,

Ayman H. El Deeb,

Naglaa M. Hagag

и другие.

International Journal of Veterinary Science and Medicine, Год журнала: 2023, Номер 11(1), С. 55 - 86

Опубликована: Июль 10, 2023

COVID-19 outbreak was first reported in 2019, Wuhan, China. The spillover of the disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), to a wide range pet, zoo, wild, and farm animals has emphasized potential zoonotic reverse viral transmission. Furthermore, it evoked inquiries about susceptibility different animal species SARS-CoV-2 infection role these as reservoirs. Therefore, studying susceptible non-susceptible hosts for could give better understanding virus will help preventing further outbreaks. Here, we review structural aspects spike protein, effect mutations observed impact ACE2 receptor variations on inter-species Moreover, chain reviewed. Combination high mutation rate homology cellular receptors enable transcend barriers facilitate its transmission between humans animals.

Язык: Английский

Процитировано

11
The natural virome and pandemic potential: Disease X DOI Creative Commons
Philip Lawrence,

Michelle Heung,

Julia Nave

и другие.

Current Opinion in Virology, Год журнала: 2023, Номер 63, С. 101377 - 101377

Опубликована: Ноя. 22, 2023

Over the last decade, emergence of several zoonotic viruses has demonstrated that previously unknown or neglected pathogens have potential to cause epidemics and therefore pose a threat global public health. Even more concerning are estimated 1.7 million still-undiscovered present in natural environment 'global virome', with many these as-yet uncharacterized predicted be pathogenic for humans. Thus, order mitigate disease prevent future pandemics, it is crucial identify extent viral threats which humans may become exposed. This requires cataloguing exist within their various diverse host species, also understanding viral, host, environmental factors dictate circumstances result spillover into We address here strategies can implemented as countermeasure initiatives reduce risk new diseases.

Язык: Английский

Процитировано

11
One Digital Health - Wearable Technologies bridging the gap between Humans and Pets: A Viewpoint towards Healthcare 5.0 (Preprint) DOI Creative Commons
Mostafa Haghi,

Samira Abani,

Soheil Khooyooz

и другие.

Опубликована: Фев. 7, 2025

UNSTRUCTURED This viewpoint explores the transformative potential of integrating health monitoring between humans and pets through wearable technology, underscoring interconnected nature human-pet health. Wearable technologies mark a transition in healthcare evolution, from paternalistic (Healthcare 1.0) to reactive 2.0), proactive 3.0), data-integrated care 4.0). The next stage, Healthcare 5.0, envisions seamless integration human pet data, fostering more holistic approach disease prevention management. paper examines parallel evolution monitoring, assessing current their enhance both fields. We structure our discussion around five key themes: (i) managing chronic conditions, (ii) physical activity, (iii) behavioral mental health, (iv) early detection, (v) clinical applications. not only improve management but also enable detection zoonotic emerging diseases, contributing public strategies. Additionally, we highlight reusability devices for pets, which can reduce costs accelerate implementation. symbiotic fosters mutual benefits. necessity an integrated, linked platform is emphasized, as it enables real-time data analysis insights, ultimately leading better diagnostic accuracy, optimized treatment plans, enhanced quality life pets. By repurposing advancing contribute collection, patient-centered care, predictive analytics, preventive healthcare—ultimately accelerating realization 5.0.

Язык: Английский

Процитировано

0